Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC–MS/MS

Application of microcrystalline cellulose as an efficient and cheap sorbent for the extraction of metoprolol from plasma and wastewater before HPLC–MS/MS determination

“…Removal of the sample interferences and/or preconcentration must be performed prior to metoprolol analysis (Mohebbi et al, 2018). Sample preparation for metoprolol extraction based on solid-phase extraction (SPE) (Meloche et al, 2021) and liquid-liquid extraction using different solvents (Wang et al, 2019) has been reported so far. In SPE, the extraction procedure was performed by adsorption of the analytes onto a sorbent filled into a cartridge.…”