Isocordoin Derivatives From the Root Extract of Lonchocarpus xuul

Yam-Puc, Alejandro; Peña‐Rodríguez, Luis M.

doi:10.29356/jmcs.v53i1.1012

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Psoralea corylifolia , a known traditional medicine for Indians and Chinese, has also yielded bavachromanol, a novel natural chalcone [ 26 ]. Dihydrochalcone, dihydroisocordon, and flemistrictin B have been isolated from Lonchocarpus xuul root extract [ 27 ]. In a comprehensive review by Wang et al (2020), about 42 chalcones isolated from licorice have been reported [ 28 ].…”

Section: Naturally Occurring Chalconesmentioning

confidence: 99%

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Rudrapal¹,

Khan

Dukhyil

et al. 2021

Molecules

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Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids. Chalcones and their natural derivatives are important intermediates of the flavonoid biosynthetic pathway. Plants containing chalcones have been used in traditional medicines since antiquity. Chalcones are basically α,β-unsaturated ketones that exert great diversity in pharmacological activities such as antioxidant, anticancer, antimicrobial, antiviral, antitubercular, antiplasmodial, antileishmanial, immunosuppressive, anti-inflammatory, and so on. This review provides an insight into the chemistry, biosynthesis, and occurrence of chalcones from natural sources, particularly dietary and medicinal plants. Furthermore, the pharmacological, pharmacokinetics, and toxicological aspects of naturally occurring chalcone derivatives are also discussed herein. In view of having tremendous pharmacological potential, chalcone scaffolds/chalcone derivatives and bioflavonoids after subtle chemical modification could serve as a reliable platform for natural products-based drug discovery toward promising drug lead molecules/drug candidates.

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Section: Naturally Occurring Chalconesmentioning

confidence: 99%

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Rudrapal¹,

Khan

Dukhyil

et al. 2021

Molecules

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“…(Sapindaceae), an endemic plant commonly used in Yucatecan traditional medicine to treat infections, showed marked in vitro and in vivo activities against Trypanosoma cruzi. 22 The bioassay-guided purification of the crude extract yielded a bioactive fraction containing a mixture of the sesquiterpene βcaryophyllene oxide (26) and the triterpene lupenone (28), both of which were not active when tested separately. 39 Recently, the synergistic effect of a 1:4 mixture of 26 and 28 was confirmed when tested against epimastigote forms of T. cruzi.…”

Section: ■ Screening the Mayan Pharmacopeiamentioning

confidence: 99%

“…In the initial investigation of the phytochemical components from Lonchocarpus spp., the chromatographic fractionation of the hexane-soluble portion of the leaf methanolic extracts of Lonchocarpus xuul Lundell and L. yucatanensis Pittier led to the isolation of the new chalcone 4,2′-dimethoxy-6′-hydroxylonchocarpin ( 1 ) . In addition, purification of the root extract of L. xuul yielded two isocordoin derivatives identified as dihydroisocordoin ( 2 ) and flemistrictin B ( 3 ); a third chalcone, having the same molecular formula and similar spectroscopic data to those of 3 , was also isolated from the root extract of L. xuul and identified as epi -flemistrictin B ( 4 ). The configuration at the C-2″ position of the epimeric chalcones 3 and 4 was established on the basis of theoretical calculations of the H-2″ chemical shift for each of the epimeric structures; the results showed that the H-2″ in the alpha orientation appears at a significantly higher field than that in the beta orientation …”

Section: Natural Products From the Yucatan Floramentioning

confidence: 99%

Natural Products from the Yucatecan Flora: Structural Diversity and Biological Activity

2019

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The Yucatan Peninsula possesses a unique climate, geology, landscape, and biota that includes a distinct flora of over 2300 species; of these, close to 800 plants are used in what is known as Mayan traditional medicine, and about 170 are listed as native or endemic. Even though the flora of the Yucatan peninsula has been widely studied by naturalists and biologists, to date, phytochemical and pharmacological knowledge of most of the plants, including the medicinal plants, is limited. Presently, phytochemical studies carried out on plants from the Yucatecan flora have resulted in the identification of a wide variety of natural products that include flavonoids, terpenoids, polyketides, and phenolics with cytotoxic, antiprotozoal, antibacterial, anti-inflammatory, analgesic, antioxidant, and antifungal activities. This review describes the main findings in over 20 years (1992 to 2018) of exploring the natural product diversity of the Yucatecan flora.

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Isocordoin Derivatives From the Root Extract of Lonchocarpus xuul

Abstract: Two natural isocordoin derivatives, dihydroisocordoin (1) and flemistrictin B (2), were isolated from the root extract of Lonchocarpus xuul. Both metabolites were identified on the basis of their spectroscopic data and by comparing them with those reported in the literature.

Cited by 2 publications

References 7 publications

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Natural Products from the Yucatecan Flora: Structural Diversity and Biological Activity

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