Isochromosome 17q in cell lines of two cases of B cell chronic lymphocytic leukemia

Vahdati, M.; Graafland, H; Emberger, J M

doi:10.1016/0165-4608(83)90005-5

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…chromosome 17 long arm [6], Worthy of note is that the 2 cases of B cell chronic lymphocytic leukemia reported by Vahdati et al [8] with the isochromosome 17q (long arm) in their cell lines underwent a prostatectomy at that time. Prostatic malignancy was not reported then [8] but it has happened that malignancy was not detected on histopathologic ex aminations [1].…”

Section: Casementioning

confidence: 99%

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

Shabtai¹,

Lask²,

Kimchi³

et al. 1985

Urol Int

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Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be involved. Concomitance of these particular different primary malignant neoplasms must therefore be kept in mind in the evaluation of patients’ conditions.

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Section: Casementioning

confidence: 99%

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

Shabtai¹,

Lask²,

Kimchi³

et al. 1985

Urol Int

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The Cytogenetics of Hematologic Neoplasms

Meloni‐Ehrig¹

2012

The Principles of Clinical Cytogenetics

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Small metacentric marker chromosomes, particularly isochromosomes, in cancer

Atkin

Baker

1988

Hum Genet

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At least two types of small metacentrics, which are isochromosomes for 12p and either 4p or 5p, respectively, are significantly associated with certain types of cancer and their formation may represent important stages in the development of these tumours. The specificity of the i(12p) for testicular cancer is now well established (it may also be present, however, in dysgerminomas and mixed Müllerian tumours of the ovary). This review is therefore mainly concerned with another marker, probably an i(5p) although an i(4p) should also be considered. Recent data suggest that this marker represents a significant chromosomal change occurring with a fairly high frequency in a variety of cancers, including carcinomas of the cervix, ovary, breast, bladder and bronchus (excluding small-cell carcinomas). These isochromosomes may contribute to tumour development through gene amplification; consistent with this is the frequent presence of these markers in two or more copies.

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Isochromosome 17q in cell lines of two cases of B cell chronic lymphocytic leukemia

Cited by 5 publications

References 13 publications

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

The Cytogenetics of Hematologic Neoplasms

Small metacentric marker chromosomes, particularly isochromosomes, in cancer

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