1988
DOI: 10.1007/bf00280545
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Small metacentric marker chromosomes, particularly isochromosomes, in cancer

Abstract: At least two types of small metacentrics, which are isochromosomes for 12p and either 4p or 5p, respectively, are significantly associated with certain types of cancer and their formation may represent important stages in the development of these tumours. The specificity of the i(12p) for testicular cancer is now well established (it may also be present, however, in dysgerminomas and mixed Müllerian tumours of the ovary). This review is therefore mainly concerned with another marker, probably an i(5p) although… Show more

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Cited by 18 publications
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