Islet cell transplantation today

Bretzel, Reinhard G.; Jahr, H; Eckhard, Michael; Martín, I. Concepción; Winter, Daniel T; Brendel, Mathias D.

doi:10.1007/s00423-007-0183-4

Cited by 53 publications

(27 citation statements)

References 119 publications

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“…We assume that the lack of a statistically significant reduction in HbA1c in our study probably resulted from the slower decline in C-peptide in the absence of immunosuppressive therapy, which is usually administered during islet cell transplant. 10 Similar results were achieved in a study by Bretzel and associates, 11 who also did not administer immunosuppressive therapy to their stem cell transplant patients with DM.…”

Section: Discussionsupporting

confidence: 72%

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Tuganbekovа

Ulyanova²,

Taubaldieva³

et al. 2015

Exp Clin Transplant

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Objectives: To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2. Materials and Methods: Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour. The quantity of fetal stem cells infused was ≥ 5-8*10⁶. We analyzed the patients' C-peptide and glycated hemoglobin levels both before and 3 months after fetal stem cell transplant. Results: In patients with diabetes mellitus type 1, fetal stem-cell transplant led to a significant increase in C-peptide levels, from 0.09 ± 0.01 ng/mL to 0.20 ± 0.07 ng/mL, after 3 months (P < .008). Conclusions: Treatment with fetal pancreatic stem cells may be beneficial for treating patients with type 1 or type 2 diabetes.

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Section: Discussionsupporting

confidence: 72%

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Tuganbekovа

Ulyanova²,

Taubaldieva³

et al. 2015

Exp Clin Transplant

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“…Neonatal wave of b cell apoptosis may be a trigger for b cell-directed autoimmunity [2]. Recent studies suggest that endoplasmic reticulum (ER) stress plays an important role in the loss of b cells [3][4][5][6]. People with type 1 diabetes have normal exocrine pancreatic function, making b cell rather than whole organ transplantation an attractive option.…”

Section: Introductionmentioning

confidence: 99%

The immunosuppressive and protective ability of glucose-regulated protein 78 for improvement of alloimmunity in β cell transplantation

Wang

Liu

et al. 2007

Clinical and Experimental Immunology

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SummaryAn insulinoma cell line, NIT-1, transfected with glucose-regulated protein 78 (GRP78) was established, namely NIT-GRP78, and used to study the immunosuppressive and protective ability of GRP78. In extended cytotoxic T lymphocyte (CTL) killing assay, NIT-1-primed lymphocytes were more cytotoxic in killing b cells than NIT-GRP78-primed lymphocytes. Severe necrosis was observed only when the NIT-1-primed lymphocytes were cultured with NIT-1 b cells, but not with NIT-GRP78 cells. In addition, an increase of interleukin (IL)-4 secretion from b cell-primed splenocytes when GRP78 presence was observed in cytokine enzyme-linked immunosorbent assay (ELISA). Diabetic mice reached normoglycaemia promptly and gained weight after transplantation of either NIT-1 or NIT-GRP78 cells. However, the recipient mice transplanted with NIT-GRP78 cells lived much longer than those recipients transplanted with NIT-1 cells, which was due apparently to prolonged insulin production by the transplanted NIT-GRP78 cells. In fact, we observed a significant increase of insulin concentration after glucose stimulation of diabetic mice received NIT-GRP78 cells at day 7 post-transplantation. From the results we propose that GRP78 could have a dual function in both protecting NIT-1 cells from CTL-mediated lysis and stimulating a population of T helper 2 cells to down-regulate the immune response to the transplanted b cells.

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“…[57,58] Yapılan ilk uygulamalar çok verimli bir sonuç göstermemitir. [59] Her ne kadar yöntem gelitirilmi olsa da donör sayısın-daki azlık, elde edilen hücre sayısında yetersizlik ve alıcının uzun süre boyunca immün sisteminin baskılanması, söz konusu yöntemin kullanılılı¤ını azaltmaktadır. [60][61][62] Günümüzde halen diyabet tedavisine yönelik MKH nakli çalımaları deneysel aamadadır ve çeitli kök hücre tiplerinde yapılan aratırmalara göre CD34 + kemik ili¤i ve kordon kanı kök hücreleri, di¤er kaynaklardan elde edilen mezenkimal hücrelere oranla daha iyi sonuçlar vermitir.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

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Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

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Islet cell transplantation today

Cited by 53 publications

References 119 publications

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The immunosuppressive and protective ability of glucose-regulated protein 78 for improvement of alloimmunity in β cell transplantation

Stem cells; mesenchymal stem cells and current clinical applications

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