Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion

Olguner, Çimen; Koca, Uğur; Kar, Anand; Karcı, Ayşe; Islekel, Gul Huray; Canyilmaz, M; Mavioğlu, Ömür; Kızıldağ, Servet; Ünlü, Gürcan; Elar, Zahi̇de

doi:10.1111/j.1399-6576.2006.00938.x

Cited by 50 publications

(40 citation statements)

References 34 publications

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“…There were many reports about intestinal ischemia and reperfusion resulted in the increase of MDA and decrease of SOD activity, toxic-free oxygen radicals are produced in the ischemic tissue [33,34] . Our study also demonstrated that ischemia-reperfusion injury elevated the oxygen radicals and lipid radicals.…”

Section: Sham Groupmentioning

confidence: 99%

Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats

Hei¹

2007

WJG

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AIM:To investigate the effects of Cromolyn Sodium (CS) pretreated prior to reperfusion on the activity of intestinal mucosal mast cells (IMMC) and mucous membrane of the small intestine in ischemia-reperfusion (IR) injury of rats. METHODS:Thirty-two Sprague-Dawley (SD) rats were randomly divided into four groups: sham group (group S), model group (group M), high and low dosage of CS groups, (treated with CS 50 mg/kg or 25 mg/kg, group C1 and C2). Intestinal IR damage was induced by clamping the superior mesenteric artery for 45 min followed by reperfusion for 60 min. CS was intravenouly administrated 15 min before reperfusion. Ultrastructure and counts of IMMC, intestinal structure, the expression of tryptase, levels of malondisldehyde (MDA), TNF-α, histamine and superoxide dismutase (SOD) activity of the small intestine were detected at the end of experiment. RESULTS:The degranulation of IMMC was seen in group M and was attenuated by CS treatment. Chiu's score of group M was higher than the other groups. CS could attenuate the up-regulation of the Chiu's score, the levels of MDA, TNF-α, and expression of tryptase and the down-regulation of SOD activity and histamine concentration. The Chiu's score and MDA content were negatively correlated, while SOD activity was positively correlated to the histamine concentration respectively in the IR groups. CONCLUSION:Pretreated of CS prior to reperfusion protects the small intestine mucous from ischemiareperfusion damage, the mechanism is inhibited IMMC from degranulation.

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Section: Sham Groupmentioning

confidence: 99%

Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats

Hei¹

2007

WJG

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“…Since functional derangement normally precedes evidence of structural organ injury, the experimental ischemia period must be long enough to allow for the structural changes to develop. Although histological evidence of injury was demonstrated only in the lung, the biochemical evidence of simultaneous hepatic and renal dysfunction indicates that multiple organ dysfunctions following hindlimb ischemia reperfusion occur as a central systemic event rather than sequential failure of individual organs 4,5,6 . Multiple pharmacological agents could potentially limit reperfusion injury, including substances that target free radicals, limit initiation of the inflammatory response, or serve as substrate for compounds that preserve endothelial function 7 .…”

Section: Introductionmentioning

confidence: 99%

The effects of pentoxifylline into the kidneys of rats in a model of unilateral hindlimb ischemia/reperfusion injury

et al. 2008

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PURPOSE: To study the role of pentoxifylline (PTX) on remote kidney injury caused by muscle ischemia of left hindlimb of rats. METHODS: After xylazine and ketamine anesthesia, the left hindlimb of rats (n=66) were submitted to 6 hours ischemia (clamping the left common iliac artery). Three groups were used: sham group (SG, n=6), early group (EG, n=30) with reperfusion after 4 hours and late group (LG, n=30) with reperfusion after 24 hours. The saline solution (EG1, n=10 and LG1, n=10) or PTX (40mg.Kg-1) was administered in the reperfusion beginning (EG2, n=10/LG2, n=10) or divided in two doses in the ischemia beginning and reperfusion beginning (EG3, n=10/LG3, n=10). The plasmatic creatinokinase, urea, creatinine, sodium and potassium values were measure and histological samples from left kidney were prepared and H&E stained for scored cellular necrosis and degeneration of kidney tubules and thickness glomerulus determination. The apoptosis index was determined by immunohistochemical expression of the caspase-3. The tests of Mann-Whitney and Kruskal-Wallis (p < 0.05) were applied. RESULTS: The urea (90.5 ± 30.96 mg.dL-1), creatinine (2.28 ± 0.54 mg.dL-1), potassium (16 ± 3.66 mmol.dL-1) and mesangium thickness (0.97 ± 0.42 µm) values were significantly higher in group LG3. There was no significantly difference of caspase 3 expression between EG2 (16.35 ± 1.65%) and LG3 (15.57 ± 2.54%), and both were significantly worse than SG (9.8 ± 1.98%). CONCLUSIONS: The PTX has some protecting effect on remote kidney injury due to hindlimb ischemia/reperfusion injury only in the early phase of reperfusion.

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“…Turnike altında uygulanan ortopedik cerrahi girişimler, serbest kas flebi transplantasyonları ve periferik arteriyel tromboembolizm gibi durumlarda uygulanan İÖ, hem ilgili ekstremiteleri hem de kalp, akciğer gibi uzak organları iskemi-reperfüzyon hasarına karşı korur (71) .…”

Section: Ekstremitelere Uygulanan Cerrahiler Ve Serbest Kas Flebi Traunclassified

Clinical Importance of Ischemic Preconditioning

Oncel¹,

Dinçer²,

Cinel³

2012

GKDA Derg

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Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion

Abstract: IP pretreatment reduces lipid peroxidation and lung injury caused by lower limb IR.

Cited by 50 publications

References 34 publications

Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats

Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats

The effects of pentoxifylline into the kidneys of rats in a model of unilateral hindlimb ischemia/reperfusion injury

Clinical Importance of Ischemic Preconditioning

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