Ischemic preconditioning accelerates the fatty acid oxidation of rat hearts

Matsuki, Akira; Nozawa, Takashi; Igawa, Akihiko; Igarashi, Norio; Nakadate, Teruo; Fujii, Naohiko; Inoue, Hiroshi

doi:10.1016/j.ijcard.2008.01.014

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Different cycles of local or remote preconditioning significantly reduced the lactate accumulation where the myocardial lactate was normalized by 3 cycles of local preconditioning. The accelerated fatty acid oxidation by ischemic preconditioning could decrease the shift to glucose metabolism during ischemia and thus would decrease the anaerobic glycolysis and lactate accumulation (Matsuki et al, 2009). In addition, activation of Na + /H + exchanger by preconditioning or repeated intracellular acidification could increase acid extrusion during ischemia and support faster recovery of mechanical function (Lundmark et al, 1999).…”

Section: Groupsmentioning

confidence: 99%

Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Ahmed¹,

Salem²,

Attia³

et al. 2012

Life Sciences

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Section: Groupsmentioning

confidence: 99%

Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Ahmed¹,

Salem²,

Attia³

et al. 2012

Life Sciences

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Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury

Tian¹,

Zhao²,

Zhang³

et al. 2023

Biomedicine & Pharmacotherapy

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Untargeted metabolic profiling reveals potential biomarkers in myocardial infarction and its application

et al. 2010

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Although some important biomarkers for myocardial injury have been identified, there still lacks a systematic view of the development and progression of myocardial infarction, including enzymatic regulation, metabolite levels, fluxes, etc., which are pivotal to elucidate the physiological mechanism of disease. Here we present an untargeted analytical approach based on gas chromatography coupled with mass spectrometry (GC-MS) to map the temporal metabolic profilings in blood sera of myocardial infarction rat model prepared by left coronary artery ligation. Using XCMS software (http://metlin.scripps.edu/download/), data processing was simplified greatly. We identified the changes in circulating levels of 24 metabolites during the myocardial ischemia. By combination of previous proteomic results, it gives rise to a new insight view of energy metabolism changes referring to anaerobic glycolysis, citric acid cycle, fatty acid beta-oxidation, and some amino acids metabolism. With these altered metabolism pathways as possible drug targets, we validated a role for the presented metabonomic profiling in the systematic understanding of the action mechanism of component-complex medicine herbs, such as Radix Ophiopogonis, a widely-used anti-myocardial ischemia herbal medicine in Asia.

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Ischemic preconditioning accelerates the fatty acid oxidation of rat hearts

Cited by 3 publications

References 26 publications

Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury

Untargeted metabolic profiling reveals potential biomarkers in myocardial infarction and its application

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