Ischemic Heart Disease in Subjects of Young Age: Current State of the Problem: Prevalence and Cardio-Vascular Risk Factors

Andreenkо, E. Yu.; YAvelov, I. S.; Loukianov, М. М.; Vernohaeva, A. N.; Drapkina, O. M.; Boytsov, S. A.

doi:10.18087/cardio.2018.10.10184

Cited by 15 publications

(13 citation statements)

References 13 publications

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“…[ 28 ] As for FBXO17, previous results showed that FBXO17 expression in tumor tissues of hepatocellular carcinoma (HCC) patients was markedly higher than that in adjacent tissues. [ 29 ] It might promote the malignant progression of HCC by inhibiting the wnt/β-catenin pathway. [ 30 ] In lung adenocarcinoma cells, FBXO17 was observed to promote cell proliferation through activation of Akt.…”

Section: Discussionmentioning

confidence: 99%

Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

Gao

Shi²,

Yao³

et al. 2020

Medicine

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Section: Discussionmentioning

confidence: 99%

Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

Gao

Shi²,

Yao³

et al. 2020

Medicine

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“…Ji Wang et al reported that TUBA1C may promote the migration and proliferation of hepatoma cells possibly through the cell cycle signal pathway (26). As for FBXO17, previous results showed that FBXO17 expression in tumor tissues of hepatocellular carcinoma (HCC) patients was markedly higher than that in adjacent tissues (27). It might promote the malignant progression of HCC by inhibiting the wnt/βcatenin pathway (28).…”

Section: Discussionmentioning

confidence: 99%

STXBP5L and its related molecules as potential biomarkers in lymph node metastatic breast cancer

Gao¹,

Shen

Shi

et al. 2020

Preprint

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BackgroundLymph node metastasis is a common problem in breast cancer, and its underlying molecular mechanism is still unclear. The purpose of this study is to research the molecular mechanism and to explore the key RNAs and pathways that mediate lymph node metastasis in breast cancer.MethodsGSE100453 and GSE38167 were downloaded from the Gene Expression Omnibus (GEO) database and 569 breast cancer statistics were also downloaded from the TCGA database. Differentially expressed miRNAs were calculated by using R software and GEO2R. Gene ontology and Enriched pathway analysis of target mRNAs were analyzed by using DAVID and R software. The PPI network was constructed by using Metascape and Cytoscape software.ResultsIn total, 6 differentially expressed miRNAs were selected, and 499 mRNAs were identified after filtering. The research of KEGG indicated that mRNAs enriched in many cancer pathways. Besides, some hub mRNAs were analyzed after constructing the PPI network. A total of 3 out of 6 miRNAs had a significant relationship with the overall survival (P<0.05) and showed a good ability of risk prediction model of over survival.ConclusionBy utilizing bioinformatics analyses, differently expressed miRNAs were identified and constructed a complete gene network. Several potential mechanisms and therapeutic and prognostic targets of lymph node metastasis were also demonstrated in breast cancer.

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“…Это обусловлено главным образом ростом распространенности факторов риска (ФР) развития ССЗ. По сравнению с лицами пожилого возраста у больных с ранним дебютом ИБС чаще встречаются такие ФР, как курение, абдоминальное ожирение (АО), отягощенная наследственность, чем такие, как сахарный диабет (СД) и артериальная гипертензия [2][3][4].…”

Section: Introductionunclassified

Blood Adipokins in Young People with Early Ischemic Heart Disease on the Background of Abdominal Obesity

et al. 2021

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Aim To study blood adipokines spectrum in people aged 25–44 years with early ischemic heart disease (IHD), including that associated with abdominal obesity (AO).Material and methods A cross-sectional study was performed on a random sample of the population aged 25–44 years in Novosibirsk. 1457 subjects (653 men, 804 women) were evaluated. This study included 123 people divided into four study subgroups: subgroup 1, with IHD associated with AO (n=24); subgroup 2, with IHD and without AO (n=25); subgroup 3, without IHD and with AO (n=44); and subgroup 4, without either IHD or AO (n=30). Concentrations of serum adipokines were measured simultaneously by multiplex assay with a Luminex MAGPIX flow fluorometer and by immune enzyme assay with a MULTISCAN analyzer.Results Subjects with early IHD had lower blood concentrations of adipsin and visfatin than subjects without IHD. Subjects with early IHD associated with AO had higher blood concentrations of adipsin, plasminogen activator inhibitor-1, and leptin and lower concentrations of monocyte chemoattractant protein-1 (MCP-1) and visfatin compared to subjects with early IHD and without AO. The multivariate logistic regression analysis showed that lower blood concentrations of MCP-1 were associated with a likelihood of early IHD.Conclusion In young people aged 25–44 years, lower blood concentrations of MCP-1 were associated with a likelihood of early IHD, including that associated with AO.

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Ischemic Heart Disease in Subjects of Young Age: Current State of the Problem: Prevalence and Cardio-Vascular Risk Factors

Cited by 15 publications

References 13 publications

Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

STXBP5L and its related molecules as potential biomarkers in lymph node metastatic breast cancer

Blood Adipokins in Young People with Early Ischemic Heart Disease on the Background of Abdominal Obesity

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