Ischemic Cardiopathy from CIS-Diamminedichloroplatinum (CDDP)

Abstract

The authors report a case of ischemic cardiopathy that occured during therapy with CDDP in a woman with an ovarian cancer which had been extensively pre-treated with adriamycin.

Cisplatin and 5-Fu Combined with Radiotherapy and Surgery in the Treatment of Squamous Cell Carcinoma of the Esophagus Palliative Effects and Tumor Response

“…Pain (19)(20)(21). The adverse cardiac effects were investigated separately and are reported elsewhere (22).…”

Cardiac and cardiovascular toxicity of nonanthracycline anticancer drugs

“…Acute cardiac symptoms reported with cisplatin-based chemotherapy have included arrhythmias, chest pain and infrequently elevated cardiac enzymes suggestive of MI [75][76][77][78][79][80][81][82][83], as well as acute cerebrovascular accidents [80,84,85]. However, acute cardiotoxicity associated with cisplatin-based therapy is rare and platinum analogs are often administered in combination with other chemotherapeutic agents.…”

“…PVB 1.9-fold increased risk MI [19]. Case reports of acute toxicity [75][76][77][78][79][80][81][82][83] Acute toxicity reported in combination with other chemotherapeutic agents [75][76][77][78][79][80][81][82][83] Mitomycin CHF 2-15% [97][98][99][100][101][102] Usually observed in patients treated with simultaneous or previous anthracyclines [97][98][99][100][101][102] Bleomycin Pericarditis Ischemia and infarction 2.8% in one series [103] Carmustine Hypotension Sinus tachycardia Chest pain…”

Electrocardiographic Changes Simulating Acute Myocardial Infarction or Ischemia Associated with Combination Chemotherapy with Etoposide, Cisplatin, and 5-Fluorouracil

“…There might be a synergistic toxic effect between the 5–FU and cisplatin or the 5–FU and etoposide. There are few case reports suggesting endovascular toxicity of cisplatin 15 , 16 ) . Also, cisplatin-induced electrolyte imbalance and magnesium depletion might be a predisposing factor for the observed EKG changes.…”