Ischemia/reperfusion injury of skeletal muscle: Plasma taurine as a measure of tissue damage

Taurine Attenuates Multiple Organ Injury Induced by Intestinal Ischemia Reperfusion in Rats

“…The roles of taurine thus far elucidated include membrane stabilization, osmoregulation, bile salt formation, growth regulation, calcium homeostasis, and apoptosis modulation [31], all of which contribute to a cyto-protective effect against a variety of mechanisms of cell damage [32], including I/R injury. The serum level of taurine has been used as a sensitive indicator to evaluate I/R injury [33,34], and taurine has been applied in several animal models to protect organs from I/R injury. For instance, taurine protects intrinsic nerves of guinea pig detrusor strips against anoxia/glucopenia and reperfusion injury [35], electrophysiological function in skeletal muscle against both early and late ischemia-reperfusion injury [19], and hearts from neutrophil-induced reperfusion injury [36] and attenuates cold I/R injury in rat livers [17].…”

Ischemic preconditioning improves oxygenation of exercising muscle in vivo

“…The histological results that there were no differences among all groups suggests that the flattening of HbO 2 in the I/R group was not caused by the morphological changes, but by the functional damages following the global ischemia. Although some previous articles showed that severe reperfusion injury induces interstitial edema in muscle [24,27], it may be due to the different procedures of arterial occlusion. Increased MPO activity after reperfusion of ischemic muscle demonstrates an influx of neutrophils in muscle tissue during reperfusion [6,23], and the extravasated neutrophils play an active role in ischemia-reperfusion injury [28 -31].…”

Effect of Mailuoning injection on 8-iso-prostaglandin F2 alpha and superoxide dismutase in rabbits with extremity ischemia–reperfusion injury

“…The model of posterior limb IR injury in rabbits was established according to the method described by Nanobashvili et al [20]. The animals had free access to food and water; however, the food was withdrawn 12 h before the beginning of the experiment.…”