Ischemia-Modified Albumin May be a Novel Marker for the Diagnosis and Follow-up of Necrotizing Enterocolitis

Yakut, Ibrahim; Tayman, Cüneyt; Öztekin, Osman; Namuslu, Mehmet; Karaca, Fahri; Köşüş, Aydın

doi:10.1002/jcla.21661

Cited by 33 publications

(37 citation statements)

References 27 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This situation can be explained in two ways. First, IMA levels might have increased as a result of hypoxia occurring in tissues after intestinal microvascular ischemia, which is held responsible for the classical clinic of IBD . Second and most likely cause may be due to high levels of oxidative stress and chronic inflammation in patients with IBD compared with the control group .…”

Section: Discussionmentioning

confidence: 92%

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

Kaplan¹,

Yüksel²,

Ateş

et al. 2016

J of Gastro and Hepatol

View full text Add to dashboard Cite

This is the first study showing that IMA levels in IBD were determined higher in comparison with the control group. Moreover, IMA being a predictor for IBD and being positively correlated with disease activity indexes were determined for the first time in the study. In accordance with these results, it is possible to say that IMA in IBD might be related with the pathogenesis of disease and correlated with the severity of the disease.

show abstract

Section: Discussionmentioning

confidence: 92%

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

Kaplan¹,

Yüksel²,

Ateş

et al. 2016

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Yakut et al [13] have reported that IMA levels are sensitive and effective marker for diagnosing NEC in close association with intestinal hypoxia, monitoring and decision-making for surgery in preterm infants. Kumral et al [12] have stated that asphyxia in low birth weight infants exists more than term infants, and this situation increases reactive oxygen species [21].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, few studies have determined that cord blood levels of IMA are higher in perinatal asfixia and complicated deliveries thought to be associated with fetal distress, hypoxia and oxidative stress in newborns. Additionally, some clinical and experimental studies have recently indicated elevated levels of IMA in ischemic and hypoxic conditions such as necrotizing enterocolitis (NEC) in newborns [10][11][12][13]. In these considerations, the primary aim of this study was to evaluate the diagnostic significance of serum IMA level in newborns with RDS which is a leading cause of hypoxia particularly in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

et al. 2015

View full text Add to dashboard Cite

Infants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P \ 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P \ 0.001; 95 % CI, 0.88-0.98) in the receiver operating characteristic curve.We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.

show abstract

“…16 İnflamasyona ve reaktif oksijen radikalleri (ROS) üreti-mine bağlı olarak oluşan iskemik olaylarda, serumda ölçülebilen IMA seviyeleri artan CRP ve IL-6 seviyeleri ile anlamlı derecede ilişkili bulunmuştur. 16 Nekrotizan periodontal hastalıklarda IMA seviyelerini inceleyen bir çalışma literatürde bulunmamaktadır. Yine literatürde NUP hastalarının serum CRP ve IL-6 seviyelerini değerlendiren bir çalışma yoktur.…”

Section: Gġrġġunclassified

“…[23][24][25] Hipoksi ve iskeminin, pro-inflamatuar prosesi indükle-diği bunun sonucunda nötrofillerin aktive olarak bir çok sitokini ve reaktif oksijen türünü ürettiği ve bu ürün-lerin hipoksi ve iskemide önemli patojenik mediatörler olduğu bilinmektedir. 16 IL-6, mononükleer fagositlerden salınan pro-inflamatuar bir sitokindir ve nötrofil aktivasyonu sonucunda sistemik inflamatuar bir cevap oluşturur. 26 Deneysel bir akut mezenterik iskemi modelinde, serum IMA seviyeleri ve IL-6 arasında pozitif bir korelasyon gösterilmiştir.…”

Section: Tartiġmaunclassified

Nekroti̇zan Peri̇odontal Hastaliklarda Serum İskemi̇k Modi̇fi̇ye Albümi̇n Sevi̇yeleri̇ni̇n Değerlendi̇ri̇lmesi̇: Ön Çalişma

Tayman¹,

Kurgan²,

Önder³

et al. 2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

View full text Add to dashboard Cite

Amaç: Albümin, primer olarak karaciğerden sentezlenen majör bir plazma proteinidir. İskemi, hipoksi, asidozis, süperoksid-radikal yaralanmaları gibi birçok durum, albüminin metal iyon bağlama kapasitesinde azalmaya ve metabolik olarak farklı protein üretimine neden olmaktadır. Bu değişim, ölçülebilir bir değişim olup, iskemik modifiye albümin (IMA) olarak bilinir. Serumdaki artmış iskemik modifiye albümin seviyeleri, C-reaktif protein (CRP) ve interlökin-6 (IL-6) seviyeleri ile anlamlı derecede ilişkili bulunmuştur. Bu ön çalışmanın amacı, nekrotizan ülseratif periodontal hastalıklarda IMA seviyelerini, bu seviyelerin CRP ve IL-6 seviyeleri ile ilişkisini ve bu değerlerin periodontal tedaviden sonra nasıl değiştiğini incelemektir. Gereç veYöntem: Bu çalışmada, nekrotizan ülseratif gingivitis (NUG) (1 vaka) ve nekrotizan ülseratif periodontitisin (NUP) akut ve subakut fazlarında olan hastaların (2 vaka) başlangıçtaki ve cerrahi olmayan periodontal tedavi sonrası 1. aydaki ve sistemik ve periodontal olarak sağlıklı kontrol bireylerinin (3 vaka) başlangıçtaki serum IMA, CRP ve IL-6 seviyeleri değerlendirilmiştir. Bulgular: Başlangıçtaki CRP ve IL-6 seviyeleri NUP'un akut fazında olan hastada NUP'un subakut fazında olan hastaya ve NUG hastasına göre daha yüksek bulunmuştur. CRP ve IL-6 seviyeleri nekrotizan hastalıklarda kontrol bireylerine göre daha yüksek bulunmuştur. Başlangıçtaki IMA seviyelerinin NUP hastalarında, NUG hastasına göre daha yüksek olduğu gözlenirken; en düşük değerler kontrol bireylerinde bulunmuştur. IMA, CRP ve IL-6 değerlerinin her üçü de tedavi ile birlikte kontrol seviyelerine düşüş göstermiştir. Sonuç: Bu çalışmanın sonuçları göz önüne alınırsa, nekrotizan periodontal hastalıklarda artan IMA seviyelerinin, hastalık aktivite kriteri olarak kullanılabileceğini söyleyebiliriz. Anahtar kelimeler: Nekrotizan ülseratif gingivitis, nekrotizan ülseratif periodontitis, iskemik modifiye albümin ABSTRACTAim: Albumin is a major plasma protein synthesized primarily in the liver. Various conditions; such as ischemia, hypoxia, acidosis, superoxide-radical injury cause reduction of the binding capacity of albumin for metals and cause metabolic production of different proteins. This variation is measurable and it's known as ischemia modified albumin (IMA). Increased serum levels of IMA were significantly associated with serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6). The aim of this preliminary study is to investigate the IMA levels, and the relationship between the levels of IMA and CRP and also IL-6 in patients with necrotizing ulcerative periodontal diseases. Case Reports: In this study, serum IMA, CRP and IL-6 levels were determined by ELISA method in patients with NUG, with acute and sub acute phases of NUP, and in systemically and periodontally healthy control subjects, before and after 1 month of non-surgical periodontal treatment. Results: Baseline CRP and IL-6 levels were higher inpatient with acute phase of NUP than the patients with sub acute phase of NUP, and NUG. At the same ti...

show abstract

Ischemia-Modified Albumin May be a Novel Marker for the Diagnosis and Follow-up of Necrotizing Enterocolitis

Abstract: Ischemia-modified albumin was found to be superior to CRP and IL-6 in both diagnosis and follow-up of NEC.

Cited by 33 publications

References 27 publications

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

Nekroti̇zan Peri̇odontal Hastaliklarda Serum İskemi̇k Modi̇fi̇ye Albümi̇n Sevi̇yeleri̇ni̇n Değerlendi̇ri̇lmesi̇: Ön Çalişma

Contact Info

Product

Resources

About