Ischemia‐Modified albumin level in type 2 diabetes mellitus—Preliminary report

Piwowar, Agnieszka; Knapik-Kordecka, Maria; Warwas, Maria

doi:10.1155/2008/784313

Cited by 106 publications

(110 citation statements)

References 32 publications

(50 reference statements)

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“…17 Similarly we anticipated that IMA levels will be elevated in HCV (+) HD patients, as few studies have advocated that there is a modification of albumin in both acute and chronic oxidative stress leading to elevated IMA levels. 18,19 But on the contrary we did not find any further significant increase in IMA levels in HCV (+) HD patients when compared to HCV (-) HD patients. Bilirubin is a well known antioxidant and when bound to human albumin scavenges free radical thereby protecting albumin bound fatty acids and most likely the protein itself from oxidation.…”

Section: Discussioncontrasting

confidence: 88%

“…However it is being revealed that IMA levels do rise in conditions not related to cardiac ischemia such as in diabetes 6 , ESRD 13 and HD. 11 Although studies have reported elevated IMA levels in ESRD patients 10,11,14 the impact of HCV infection on IMA levels in HD patients has not been explored further.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 However recently the role and diagnostic significance of IMA in disorders of non-cardiac origin are being explored. 6 IMA is formed as a consequence of modification of albumin by reactive oxygen species (ROS). 7 A decrease in blood flow is believed to trigger ROS formation, which consequently modify the N-terminal portion of albumin leading to IMA formation.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Kumar

Suchitra

et al. 2012

Int J of Biomed & Adv Res

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Background: Chronic hemodialysis (HD) patients are more prone for infection such as Hepatitis C virus (HCV) infection, which may be associated with increased oxidative stress (OS). Ischemiamodified albumin (IMA) levels rises not only during ischemia but also during chronic OS. Hence the study was aimed to evaluate the levels of IMA and its association with oxidative stress in HCV positive HD patients. Methods: Twenty two HCV positive [HCV (+)], 22 HCV negative [HCV (-)] patients with end stage renal disease (ESRD) on maintenance HD and 22 healthy subjects were enrolled in this crosssectional observational study. Plasma IMA was determined by spectrophotometric Co (II) -albumin binding assay. Plasma MDA was determined by spectrophotometric method. Results: Both MDA and IMA levels were significantly higher in HCV (+) and HCV (-) HD patients compared to controls (p < 0.001). A significant increase in MDA levels was observed in HCV (+) HD patients when compared with HCV (-) HD patients (p<0.001); however no change in IMA levels were noted between HCV (+) and HCV (-) HD patients. A negative correlation was observed between IMA and MDA levels in both HCV (+) (r= -0.278, p=0.178) and HCV (-) HD patients (r= -0.193, p=0.354) which were however not statistically significant. Conclusion: Plasma IMA and MDA levels were elevated in both groups of HD patients when compared to controls. However, hepatitis C infection does not appear to cause any additional increase of IMA levels in HD patients.

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Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Kumar

Suchitra

et al. 2012

Int J of Biomed & Adv Res

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“…IMA may not be specific for cardiac ischemia. There are various data on IMA in patients with different states with ischemia of non-cardiac origin such as systemic sclerosis, peripheral vascular disease, skeletal muscle ischemia, glaucoma and diabetes mellitus Montagnana et al, 2006;Piwowar et al, 2008). Also, serum IMA levels are increased in patients with gastric, prostate, neuroblastoma and soft tissue cancer (Mastella et al, 2009;StachowiczStencel et al, 2011;Fidan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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“…Although multiple reports [13][14][15] including ours 12 showed increased lipid peroxidation and impaired antioxidant status in diabetes and DR, little published data on protein markers of OS in both diabetes and DR patients are available. 11,16 Although ischemia modified albumin (IMA) has been demonstrated as a novel marker of ischemia, OS and endothelial dysfunction in diabetes [17][18][19] studies on IMA in DR patients are very scarce. To the best of our knowledge, there is only one study in the literature on IMA levels in human DR patients.…”

Section: Introductionmentioning

confidence: 99%

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Reddy

Sethi

Gupta

et al. 2015

Eye

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Purpose To investigate the role of protein oxidative damage and antioxidant defense in relationship to hyperglycemia measured as fasting plasma glucose (FPG), glycated hemoglobin (A1C), and duration of disease in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR). Methods This study recruited 23 nondiabetic subjects, 16 DM patients without any complications and 18 DR patients. The serum ischemia modified albumin (IMA) and glutathione (GSH) levels were measured. The IMA results were corrected for serum albumin. Between-group differences were studied by analysis of variance and betweenvariable associations were studied by Spearman's and partial correlations. Results IMA and cIMA values were elevated, whereas GSH was decreased in both patient groups vs controls (Po0.05), and the increase in IMA formation is not related to serum albumin changes. DR patients have much severe oxidative stress (OS) status with high IMA and cIMA, and low GSH than in the DM group (Po0.05). Both FPG and A1C levels were positively associated with IMA in DM group, while in the DR group, duration of disease too had a positive association with IMA. The antioxidant GSH had negative correlations with FPG (r = − 0.52, P = 0.02) and IMA (r = − 0.49, P = 0.03) in the DR group. Partial correlation analyses predicted mutual or independent associations among parameters. Conclusions Severe OS in DR has been associated with increased FPG, A1C, and disease duration. Both hyperglycemia and elevated oxidative damage detected as IMA are collectively associated with depleted GSH status. Our study unravels the need for monitoring of OS in addition to standard glycemic management in DR.

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Ischemia‐Modified albumin level in type 2 diabetes mellitus—Preliminary report

Cited by 106 publications

References 32 publications

Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

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