Ischemia-Modified Albumin as a Marker of Acute Coronary Syndrome: The Case for Revising the Concept of “N-Terminal Modification” to “Fatty Acid Occupation” of Albumin

Objective Ischemia-modified albumin (IMA)is a modified type of albumin protein that is formed under oxidative stress. This study aims to compare the levels of serum IMA between normotensive and preeclamptic pregnancies and to evaluate the relationship between the severity of the disease. Methods A total of 90 pregnant women aged between 18 and 45 years participated in this cross-sectional study. The levels of serum IMA were measured by enzyme-linked immunosorbent assay in 30 preeclamptic pregnant women with the severe signs of the disease, 30 preeclamptic pregnant women, and 30 normotensive pregnant women.. The study was designed as a cross-sectional clinical study. Results When the demographic characteristics were examined, statistically significant differences were found between the groups in terms of age, gestational week at birth and blood pressure. Age was higher in the preeclampsia with signs of severity group than in the normotensive group (p = 0.033). Pregnancy week was significantly the lowest in the preeclampsia with the severity signs group (p = 0.004). In normotensive patients, IMA levels were lower than in the preeclampsia groups (p < 0.001) but there was no significant difference in terms of severity of disease (p = 0.191). According to laboratory data; only the creatinine level was significantly different between the groups. Conclusion The levels of serum IMA were higher in patients with preeclampsia than in healthy pregnancies. However, there was no significant correlation in terms of preeclampsia severity; more extensive, prospective and long-term studies are needed.

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“…Intrauterine disorders-normal pregnancies, endometriosis, complicated deliveries 9. Prostatic diseases-hyperplasia or cancer 17,18…”

Section: Discussionmentioning

confidence: 99%

The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Karaşin

Çift

2020

Rev Bras Ginecol Obstet

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“…175 The N-terminus of HSA is the primary binding site for the transitional metals, cobalt and copper. 175,176 During ischemia, the metal-binding site in HSA is susceptible to biochemical changes compared with albumin from other species. The mechanism by which it reduces metalbinding ability at its N-terminal is unknown.…”

Section: St2mentioning

confidence: 99%

“…However, instead of measuring IMA using an enzyme-linked immunosorbent assay (ELISA), it is better to use the standard ACB assay, which deals with ''FA occupied'' but not actually ''N-terminal modified'' albumin. 34,176,177 Highly elevated serum levels of free fatty acids (FFA) with high levels of IMA correlated positively in myocardial ischemic patients. 178 Thus, FFA binding alters conformational changes and inhibits the metal ion binding to albumin.…”

Section: St2mentioning

confidence: 99%

“…179,180 Chronic diseases associated with ''glycated/ oxidized'' albumin, oxidative stress generates ''irreversible'' oxidation-modified albumin secondary to oxidation adducts on albumin. 176 Henceforth, the use of both standard ACB assay and ELISA tests for determining IMA levels is ideal. Although the understanding of the IMA marker is limited, its sensitivity to and specificity for myocardial ischemia before cell damage may be an enormously valuable biomarker of prognosis.…”

Section: St2mentioning

confidence: 99%

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Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases

Parsanathan

Jain

2020

Metabolic Syndrome and Related Disorders

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Cardiovascular disease (CVD) is the leading cause of fatality and disability worldwide regardless of gender. Obesity has reached epidemic proportions in population across different regions. According to epidemiological studies, CVD risk markers in childhood obesity are one of the significant risk factors for adulthood CVD, but have received disproportionally little attention. This review has examined the evidence for the presence of traditional cardiac biomarkers (nonspecific; lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, myoglobulin, glycogen phosphorylase isoenzyme BB, myosin light chains, ST2, and ischemia-modified albumin) and novel emerging cardiac-specific biomarkers (cardiac troponins, natriuretic peptides, heart-type fatty acid-binding protein, and miRNAs). Besides, noninvasive anatomical and electrophysiological markers (carotid intima-media thickness, coronary artery calcification, and heart rate variability) in CVDs and obesity are also discussed. Modifiable and nonmodifiable risk factors associated with metabolic syndrome in the progression of CVD, such as obesity, diabetes, hypertension, dyslipidemia, oxidative stress, inflammation, and adipocytokines are also outlined. These underlying prognostic risk factors predict the onset of future microvascular and macrovascular complications. The understanding of invasive and noninvasive cardiac-specific biomarkers and the risk factors may yield valuable insights into the pathophysiology and prevention of CVD in a high-risk obese population at an early stage.

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“…Another limitation is that albumin cobalt binding assay, which has been used for many years for IMA measurement, has several deficiencies. 37 , 38 Hence, this method may not reflect the accurate N-terminus binding affinity of cobalt for albumin. Finally, we demonstrated in this study that the IMA measurements on admission and from 48 to 72 hours were different.…”

Section: Limitationsmentioning

confidence: 99%

Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis?

Şahin¹,

Türkoğlu²,

Tunç³

et al. 2018

TCRM

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PurposeOxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP.Patients and methodsA total of 42 consecutive patients with AP and 43 age- and sex-matched control subjects were enrolled. Serum samples were obtained from patients with AP on admission as well as 48–72 hours after hospitalization, and from the controls, at the time of enrollment. Adjusted IMA was calculated by multiplying the IMA value of each patient with the ratio of the patient’s albumin value and the median albumin value of the study population. The severity of AP was assessed according to the modified Atlanta classification, and the patients were divided into 2 groups: mild AP and severe AP.ResultsThe serum IMA and adjusted IMA values of patients with AP on admission and those of the controls did not differ (p=0.86 and p=0.99, respectively). The second measurements of IMA and adjusted IMA in the AP group were higher than the first measurements of both the AP group and controls (for all, p<0.01). Among the IMA measurements, only adjusted IMA on admission had the ability to predict the severity of AP. Severe AP was correlated with albumin, and the area under the curve of adjusted IMA values on admission was 0.746 for differentiating patients with severe AP from mild AP with statistical significance (p=0.005).ConclusionIt was shown that IMA and adjusted IMA levels rise with the progression of AP. Lower levels of adjusted IMA predict the severity of AP. Further studies with serial measurements of IMA are warranted to explore the indicative role of IMA in the course of AP.

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Ischemia-Modified Albumin as a Marker of Acute Coronary Syndrome: The Case for Revising the Concept of “N-Terminal Modification” to “Fatty Acid Occupation” of Albumin

Cited by 30 publications

References 50 publications

The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases

Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis?

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