Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis?

Abstract

PurposeOxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP.Patients and methodsA total of 42 consecutive patients with AP and 43 age- and sex-matched control subjects were enrolled. Serum samples were obtained from patients with AP on admission as well as 48–72 hours after hospitalization, and from the controls, at the time of enrollment. Adjusted IMA was calculated by multiplying the IMA value of each patient with the ratio of the patient’s albumin value and the median albumin value of the study population. The severity of AP was assessed according to the modified Atlanta classification, and the patients were divided into 2 groups: mild AP and severe AP.ResultsThe serum IMA and adjusted IMA values of patients with AP on admission and those of the controls did not differ (p=0.86 and p=0.99, respectively). The second measurements of IMA and adjusted IMA in the AP group were higher than the first measurements of both the AP group and controls (for all, p<0.01). Among the IMA measurements, only adjusted IMA on admission had the ability to predict the severity of AP. Severe AP was correlated with albumin, and the area under the curve of adjusted IMA values on admission was 0.746 for differentiating patients with severe AP from mild AP with statistical significance (p=0.005).ConclusionIt was shown that IMA and adjusted IMA levels rise with the progression of AP. Lower levels of adjusted IMA predict the severity of AP. Further studies with serial measurements of IMA are warranted to explore the indicative role of IMA in the course of AP.

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

“…Hypoalbuminemia has been described as a negative prognostic factor in several diseases, [ 89 – 92 ]. Furthermore, low serum albumin concentrations have been shown to be associated with the severity of chronic inflammatory diseases, inflammatory bowel disease and diabetes mellitus [ 93 ], cirrhosis [ 94 ], as well as with the severity of surgical trauma [ 95 ], acute diseases [ 96 ] and sepsis [ 97 ]. In addition, in past SARS epidemics, hypoalbuminemia has been shown to be related with disease severity and increased hospital mortality [ 98 , 99 ].…”

The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters

“…Oxidative stress and the production of free radicals are responsible for the progression of pancreatic inflammation, and triggering the generation of inflammatory cytokines is the key event in the pathogenesis of acute pancreatitis. [18] We concluded that thiol-disulphide levels decreased as oxidative stress increased in acute pancreatitis. This study aims to compare the thiol-disulphide homeostasis and other blood parameters levels of patients with AP and healthy controls, and to investigate thiol-disulphide homeostasis as a marker of disease severity.…”

Effects of Long Noncoding RNA H19 on Isoflurane-Induced Cognitive Dysregulation by Promoting Neuroinflammation

“…The results of this study showed that ISO had neurotoxicity and could induce HT22 hippocampal neuronal cell death and inhibit cell survival in a dose-dependent man- ner. ROS is a by-product produced in the process of normal cell metabolism [30]. Under physiological station, there is a dynamic balance between the ROS accumulation system and antioxidant scavenging system [31].…”