Ischemia Modified Albumin as a Novel Biochemical Indicator in Peripheral Artery Patients

Abstract

Objective: Peripheral artery disease (PAD) is the name given to blocked blood flow in major arteries other than cerebral and coronary circulation. The diagnosis and treatment of PAD is very important because of the high frequency of PAD. In this study, it was aimed to investigate the possible change in next generation oxidative stress-antioxidant status indicators as a biochemical parameter that may be useful in the diagnosis and follow-up of PAD.Method: Forty healthy controls and 40 male and female patients with peripheral artery disease who applied to the Alanya Alaaddin Keykubat University Research and Training Hospital were enrolled in the study on a voluntary basis. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia modified albumin (IMA) and Thiol balance were studied with the colorimetric method. Results:The TOS (p <0.001), OSI (p <0.001), IMA (p = 0.027), total thiol (0.004) levels were higher in the peripheral artery patients compared to the control group, while the TAS (p <0.001) and native thiol / total thiol ratio (index 3) (p = 0.018) values were significantly lower. Conclusion:The increase in TOS and IMA levels may be used as an indicator of peripheral artery disease. There is an increase in inflammation in the ischemia and atherosclerosis processes. An ischemia-specific protein called ischemia-modified albumin may be used as a rapid and practical laboratory marker in common peripheral artery disease.

Farklı Konsantrasyonlardaki Monosodyum Glutamatın Koryoallantoik Membran Modelinde Anti-Anjiyojenik ve Oksidan Etkileri

“…Nowadays, researchers have gained importance to show the role of free radicals in human diseases. The harmful effects of free radicals have been shown to play a role in the formation mechanisms of diseases such as cancer, heart diseases, diabetes mellitus, and many vascular pathologies (21)(22)(23)(24)(25)(26)(27).…”

Bilimsel Araştırmalarda Oksidatif Stres ve Antioksidanlar

“…Nowadays, oxidative stress and antioxidants are frequently measured both in various experimental models established in experimental animals (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and in clinical studies (15)(16)(17)(18)(19)(20)(21), which is becoming increasingly important. For this reason, oxidant-antioxidant balance indicator parameters are very valuable in scientific research.…”

“…It disrupts protein, carbohydrate and lipid structures. As the oxidative damage that starts in this way accumulates and increases, physiological processes such as aging are accelerated, and hundreds of multifactorial fatal diseases such as cancer, cardiovascular diseases and diabetes mellitus are triggered (16)(17)(18)(19)(20). For this reason, the measurement and evaluation of oxidative stress and antioxidants is a current and important issue in health-related scientific research.…”