IS1.03: New theories of aging

Kirkwood, Tbl

doi:10.1016/s1878-7649(14)70003-8

Cited by 3 publications

(4 citation statements)

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“…Perhaps there are hundreds of specific cellular and molecular mechanisms that contribute to the intrinsic biology of aging but these can be arranged upon a small number of major theories [6]. In past decades, theories were divided for your understanding in two main aspects: they considered aging as a process scheduled under the control of genes and other mechanisms due to unscheduled (stochastic) [7][8][9].…”

Section: Towards a Classification Of Theories Of Agingmentioning

confidence: 99%

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Theories of Human Aging of Molecules to Society

Cabrera¹

2015

MOJI

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Aging is a process of deterioration of physiological functions, time-dependent, leading to homeoestenosis. The causes and mechanisms of this process are not yet fully clarified so have issued numerous theories to explain it.The article reviews the major theories of human aging, while proposing a classification that covers the fundamental mechanisms, including deregulation of the immune response (oxy-inflamm-aging) as one of the most cited today.The theories also include those relating to the psychosocial aspects of aging, taking a holistic approach to this biological process of humans.

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Section: Towards a Classification Of Theories Of Agingmentioning

confidence: 99%

“…In short, the evolutionary theories consider that no specific genes for aging, this is an unscheduled process and depends on natural selection [6,18]. …”

Section: Evolutionary Theories Of Agingmentioning

confidence: 99%

Theories of Human Aging of Molecules to Society

Cabrera¹

2015

MOJI

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“…These active oxygen species have, for centuries, generated interest most especially due to the fact that they are suspected to be the causative factor for aging and age-related pathologies like neurode generative diseases [2], cardiovascular, renal and diabetic complications. Reactive oxygen species are capable of modifying cell proteins [1] and therefore, over a given period of time, induce damage to cells that make up tissues of vital organs such as nervous and pulmonary tissues [3]. Some of the changes induced by reactive oxygen species occur extensively and are directly proportional to the level of metabolic activity in the organism [4].…”

Section: Introductionmentioning

confidence: 99%

Tissue Protein Carbonylation in Aging: A Strategic Analysis of Age-Related Protein Modification

Kolawole

Ilochi

Oluwatayo

et al. 2019

JAMPS

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Free radicals generated in a variety of biological systems have been implicated in mechanisms of aging and age-related pathologies. This study strategically revealed the varying levels of carbonylated proteins in 3 different tissues of 40 wistar rats of varying ages. Their ages include 25-30, 45-50 and 65-70 days. The brain, heart and kidney tissue homogenates were prepared and biochemically analyzed for products of protein oxidation using 2,4-dinitrophenylhydrazones and autoantibodies against carbonylated proteins. This study revealed a direct proportional relationship between age and protein carbonylation in brain, heart and kidney tissue homogenates. The level of carbonylated proteins were significantly (P≤0.05) increased in the assayed tissues as all test groups advanced in age. Oxidative modification of proteins in brain and kidney tissues showed similar trend. This age-related biochemical manifestation may be as a result of increased generation of free radicals at mitochondrial level or decreased anti-oxidant defenses as living organisms advance in age.

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“…As they appear different definitions of biological aging process, over time, we have presented many theories to explain its causes (more than 300) that include their content describing hundreds of cellular and molecular mechanisms that contribute to the specific biology intrinsic aging and, in a more synthetic, can be organized upon a small number of major theories [4,5]. At present, many studies have emphasized the importance of the association between chronic inflammation and aging, and its causal role in many diseases associated with aging such as cancer, arteriosclerosis and osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Oxidative Aging: A New Theory of Aging

Cabrera¹

2016

MOJI

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Oxidative stress leads to deregulation in key physiologic systems for the maintenance of homeostasis, like immune system and others. The immune system produces deregulation to chronic low grade inflammatory state in the aging process. That is the basis of a new theory named oxy-inflamm-aging. The article describing the basis of this theory and the current researches to support it, in Addition to STI links with the pathogenesis of the age related diseases. The author summarizes the interventions to modulate theoxi-inflamm-aging as a practical application of this theory.

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IS1.03: New theories of aging

Cited by 3 publications

References 0 publications

Theories of Human Aging of Molecules to Society

Theories of Human Aging of Molecules to Society

Tissue Protein Carbonylation in Aging: A Strategic Analysis of Age-Related Protein Modification

Inflammatory Oxidative Aging: A New Theory of Aging

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