Inflammatory Oxidative Aging: A New Theory of Aging

Cabrera, Luis

doi:10.15406/moji.2016.03.00103

Cited by 7 publications

(3 citation statements)

References 47 publications

(46 reference statements)

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“…Furthermore, inflammation can regulate the activation of the NF-kB family members which can trigger the tissue-specific ageing-related degenerative process. [27][28][29] Recent studies showed an increase in inflammatory status and NF-kB protein expression in old mice together with anti-apoptotic and antioxidant enzyme activity in pancreas, lung tissue of senescence-accelerated mice. 11,30 Mitochondrial free radical theory of ageing (MFRTA) is generating considerable interest in terms of ageing, however, what we know about MFRTA lacks consistent evidence which has led to disagreement and rejection of this idea.…”

Section: Free R Ad I C Al /Oxidative S Tre Ss Theorie S Of Ag Eingmentioning

confidence: 99%

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

Sultuybek

Soydaş

Yenmiş

2019

Clin Exp Pharma Physio

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Summary Ageing can be defined as the progressive failure of repair and maintenance systems with a consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These various types of damage promote ageing by driving cellular senescence and apoptosis. The nuclear factor‐kappa B (NF‐kB) pathway is one of the key mediators of ageing and this pathway is activated by genotoxic, oxidative and inflammatory stress, and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell‐cycle progression, and inflammation. Therefore, NF‐kB is increased in a variety of tissues with ageing, thus the inhibition of NF‐kB leads to delayed onset of ageing‐related symptoms and pathologies such as diabetes, atherosclerosis, and cancer. Metformin is often used as an anti‐diabetic medication in type 2 diabetes throughout the world and appears to be a potential anti‐ageing agent. Owing to its antioxidant, anticancer, cardio‐protective and anti‐inflammatory properties, metformin has become a potential candidate drug, improving in the context of ageing and ageing‐related diseases. An inappropriate NF‐kB activation is associated with diseases and pathologic conditions which can impair the activity of genes involved in cell senescence, apoptosis, immunity, and inflammation. Metformin, inhibiting the expression of NF‐kB gene, eliminates the susceptibility to common diseases. This review underlines the pleiotropic effects of metformin in ageing and different ageing‐related diseases and attributes its effects to the modulation of NF‐kB.

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Section: Free R Ad I C Al /Oxidative S Tre Ss Theorie S Of Ag Eingmentioning

confidence: 99%

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

Sultuybek

Soydaş

Yenmiş

2019

Clin Exp Pharma Physio

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“…Ponadto, mitochondria są głównym źródłem ROS (mtROS), a zarazem pierwszym celem narażenia na ich działanie. ROS mogą prowadzić do uszkodzeń mtDNA oraz kompleksów łańcucha oddechowego, tym samym przyczyniając się do ich zwiększonej produkcji [42]. Uszkodzone mitochondria usuwane są na drodze mitofagii [40].…”

Section: Dysfunkcja Mitochondriówunclassified

Zapalenie starcze - mechanizmy i szlaki sygnałowe

et al. 2021

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Starzenie się jest złożonym i wieloetapowym procesem, angażującym mechanizmy na poziomie molekularnym, komórkowym i tkankowym. Podczas procesu starzenia się obserwowany jest rozwój przewlekłego, sterylnego stanu zapalnego, który jest określany terminem inflammaging, czyli zapalenie starcze. Zapalenie starcze jest wymieniane jako czynnik ryzyka wystąpienia i progresji chorób przewlekłych, nie tylko tych związanych z wiekiem. Ponadto, zapalenie starcze sprzyja wzrostowi zachorowalności i śmiertelności oraz wpływa na jakość życia osób starszych. Do rozwoju zapalenia starczego przyczynia się starzenie komórkowe oraz zaburzenia w regulacji aktywacji inflamasomów, pracy mitochondriów, autofagii i mitofagii, działania systemu ubikwityna â proteasom i odpowiedzi na uszkodzenia DNA. Powyższe procesy wzajemnie na siebie oddziaływają oraz są modulowane poprzez komórkowe szlaki sygnałowe uczestniczące w regulacji odpowiedzi zapalnej tj.: szlak mTOR, RIG-I, Notch, TGF-b, Ras, oraz regulacja aktywności sirtuin. Szczególną uwagę przypisuje się czynnikowi transkrypcyjnemu NF-kB. Celem pracy jest przedstawienie procesów oraz szlaków sygnałowych leżących u podstaw zapalenia starczego z uwzględnieniem badań klinicznych i eksperymentalnych.

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“…The toxicity of free radicals contributes to the damage of cellular macromolecules (such as DNA, proteins, and lipids), inflammation, tissue damage, and subsequent cellular apoptosis (14) . Therefore, as a result, oxidative stress is related to several chronic diseases such as cancer, diabetes, cardiovascular diseases (15)(16)(17) and some neurodegenerative disorders (such as Alzheimer's disease or Parkinson's disease) (18) .The function of the antioxidant defense system of the body is to prevent any damage due to the action of free radicals (19) .…”

Section: Introductionmentioning

confidence: 99%

Riboflavin is an antioxidant: a review update

2022

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Aerobic organisms need antioxidant defense systems to deal with free radicals which either are produced during aerobic respiration or may have an external origin. Oxidative stress, which is resulted from an imbalance between the production of free radicals and the ability of antioxidant defense mechanism to deactivate them, is involved in the development of many chronic diseases such as cancer, diabetes, cardiovascular diseases, and some neurodegenerative diseases. Reinforcing the antioxidant potential of the body has been considered as a strategy which could prevent and manage such conditions. In the previous review article published by British Journal of Nutrition, in 2014, for the first time, we concluded that riboflavin could alleviate oxidative stress. Although riboflavin can serve as a prooxidant when exposed to ultraviolet irradiation, the literature is replete with studies that support its antioxidant properties. Furthermore, recent evidence suggest that riboflavin may have a therapeutic potential in many conditions in which oxidative stress is involved, although, the therapeutic efficacy of riboflavin as an antioxidant requires further study under conditions of wellness and clinical disease.

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Inflammatory Oxidative Aging: A New Theory of Aging

Cited by 7 publications

References 47 publications

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

Zapalenie starcze - mechanizmy i szlaki sygnałowe

Riboflavin is an antioxidant: a review update

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