Is weight gain associated with the incidence of periodontitis? A systematic review and meta‐analysis

Nascimento, Gustavo G.; Leite, Fábio Renato Manzolli; Do, Loc; Peres, Karen Glazer; Corrêa, Marcos Britto; Demarco, Flávio Fernando; Peres, Marco Aurélio

doi:10.1111/jcpe.12417

Cited by 119 publications

(127 citation statements)

References 51 publications

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“…Of the life-style parameters here measured, only BMI was significantly higher in patients with periodontitis compared to other groups. Strong evidence has corroborated the positive association between obesity and periodontitis [67]. Therefore, the altered gut microbiome in overweight CP individuals may have contributed to the lower diversity and high numbers of pathogenic OTUs observed.…”

Section: Discussionmentioning

confidence: 88%

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Lourenςo

Spencer

Alm

et al. 2018

Journal of Oral Microbiology

116

109

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Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction.Methods: Stool samples were obtained from individuals presenting periodontal health (PH = 7), gingivitis (G = 14) and chronic periodontitis (CP = 23). The intestinal microbiome composition was determined by Illumina MiSeq sequencing.Results: A lower alpha-diversity in the gut microbiome of individuals with CP was observed, although no significant difference among groups was found (p > 0.01). Firmicutes, Proteobacteria, Verrucomicrobia and Euryarchaeota were increased, whereas Bacteroidetes were decreased in abundance in patients with periodontitis compared to PH. Prevotella (genus), Comamonadaceae (family) and Lactobacillales (order) were detected in higher numbers in G, while Bacteroidales (order) was predominant in PH (p < 0.01). Significant correlations (rho = 0.337–0.468, p < 0.01) were found between OTUs representative of periodontal pathogens and attachment loss. Mogibacteriaceae, Ruminococcaceae and Prevotella were able to discriminate individuals with periodontal diseases from PH (overall accuracy = 84%). Oral taxa were detected in high numbers in all stool samples.Conclusions: Individuals with periodontal diseases present a less diverse gut microbiome consistent with other systemic inflammatory diseases. High numbers of oral taxa related to periodontal destruction and inflammation were detected in the gut microbiome of individuals regardless of periodontal status.

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Section: Discussionmentioning

confidence: 88%

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Lourenςo

Spencer

Alm

et al. 2018

Journal of Oral Microbiology

116

109

View full text Add to dashboard Cite

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“…A recent review has also reported that weight gain was associated with incidence of periodontitis, although only 5 studies were identified [12]. Since the unfavorable inflammatory profile associated with increased adiposity can be improved during a period of weight loss [13], what is missing in the literature is an evaluation of the effect of weight loss on periodontal tissues.…”

Section: Introductionmentioning

confidence: 99%

Weight loss after bariatric surgery and periodontal changes: a 12-month prospective study

Sales-Peres

Ceneviva

et al. 2017

Surgery for Obesity and Related Diseases

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“…The first study to identify this possible relation was carried out by Perlstein,Bissada 5 , and it showed higher bone loss in obese mice compared to non-obese ones. A recent meta-analysis showed that obese individuals may present 33% more chance of developing periodontitis than non-obese ones 6 .…”

Section: Introductionmentioning

confidence: 99%

Oral conditions and body weight in children from a public school in Manaus, AM, Brazil

Assi

Pires

Pontes

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: Estudos têm apontado para relações existentes entre prevalência de cárie e doença periodontal e ocorrência de sobrepeso ou obesidade, porém poucos estudos foram conduzidos em crianças. Objetivo: Avaliar a relação entre doença periodontal, cárie e peso corporal em crianças de uma escola pública de Manaus -AM, Brasil. Material e método: Cento e sessenta e nove crianças foram incluídas no estudo. Registros foram obtidos, tais como, dentes cariados, perdidos e obturados na dentição permanente (CPO-D) e cariados, com extração indicada e obturados em decíduos (ceo), além do registro do índice periodontal comunitário (CPI). A classificação da categoria de peso corporal foi obtida em percentil pela tabela Escore-z. Resultado: Maiores médias de peso e índice de massa corporal (IMC) foram verificados nos grupos com sobrepeso e obesidade (p<0,05). Todos os grupos foram semelhantes com relação aos códigos do CPO-D/ceo e CPI de 0 a 4 (p>0,05). Todos os grupos apresentaram maiores médias de CPI 0 em comparação aos demais códigos CPI de 1 a 4 (p<0,05), ou seja, a maioria das crianças apresentou sítios com profundidade de sondagem <3,5 mm e sem sangramento à sondagem. Conclusão: Não houve relação entre o peso corporal com a ocorrência de cárie dental e doença periodontal nessa população estudada. A obesidade e o sobrepeso não mostraram influência negativa para o aumento da prevalência dessas doenças.Descritores: Doença periodontal; cárie dental; peso corporal; obesidade; criança. AbstractIntroduction: Some studies have pointed to links between the prevalence of caries and periodontal disease, and the occurrence of overweight or obesity; but, few studies have been conducted in children. Objective: To assess the relationship between periodontal disease, tooth decay and body weight in children from a public school in Manaus, AM, Brazil. Material and method: The study included one hundred and sixty-nine children. Records were obtained of decayed, missing and filled (DMFT) permanent teeth, and of decayed, extracted, or filled (DEF) deciduous teeth, as well as the record of the community periodontal index (CPI). The classification of body weight category was obtained in percentile using the z-Score table. Result: Higher averages of weight and body mass index (BMI) were seen in the overweight and obesity groups (p<0.05). All groups were similar regarding the DMFT /DEF and CPI codes from 0 to 4 (p>0.05). All groups showed higher averages of CPI 0 in comparison with other CPI codes from 1 to 4 (p<0.05), and most of the children showed sites with probing depth <3.5 mm and without bleeding on probing. Conclusion: There was no relationship between body weight and the occurrence of dental caries and periodontal disease in the studied population. Obesity and overweight showed no negative influence on the increase in the prevalence of these diseases.

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Is weight gain associated with the incidence of periodontitis? A systematic review and meta‐analysis

Abstract: A clear positive association between weight gain and new cases of periodontitis was found. However, these results are originated from limited evidence. Thus, more studies with longitudinal prospective design are needed.

Cited by 119 publications

References 51 publications

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Weight loss after bariatric surgery and periodontal changes: a 12-month prospective study

Oral conditions and body weight in children from a public school in Manaus, AM, Brazil

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