Is Vitamin D Deficiency a Risk Factor for Helicobacter Pylori Eradication Failure?

Shatla, Mokhtar; Faisal, Ahmed S; El-Readi, Mahmoud Zaki

doi:10.7754/clin.lab.2020.200118

Cited by 5 publications

(7 citation statements)

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“…Vitamin D deficiency has been regarded as a risk factor for H. pylori eradication failure [ 20 , 45 ]. The studies investigating this topic have been summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…The increase in antibiotic resistance patterns and H. pylori eradication failure represents a threat to human health, which can lead to a higher incidence of gastric cancer [ 19 ]. Vitamin D deficiency has been regarded as one of the potential risk factors for H. pylori therapeutic failure, with studies proposing its supplementation as an adjuvant to standard medication [ 20 , 21 ]. Moreover, H. pylori positivity rates seem to be higher among populations with low serum vitamin D levels [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

et al. 2023

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Taking into account previous data that sustain a relationship between vitamin D deficiency and higher H. pylori infection positivity rates, this review aims to assess the influence of vitamin D deficiency and/or insufficiency upon the prevalence of H. pylori infection and its eradication success. Three major databases were searched for articles that analyzed a relationship between vitamin D status and H. pylori infection. The literature search retrieved a total of 37 reports, after the article selection process. Hypovitaminosis D emerged as a potential risk factor for H. pylori infection, given the higher prevalence of vitamin D deficiency and/or insufficiency among H. pylori-positive subjects. Furthermore, the same type of micronutrient deficiency has been directly linked to H. pylori eradication failure. An inverse linear relationship between vitamin D status and gastric cancer risk exists, but the additional involvement of H. pylori in this correlation is still in question. The potential benefit of oral supplements in enhancing the success of classical therapeutic regimens of H. pylori still requires future research. Future population-based studies from larger geographical areas are warranted to address this subject in more depth.

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“…Vitamin D deficiency has been regarded as a risk factor for H. pylori eradication failure [ 20 , 45 ]. The studies investigating this topic have been summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

et al. 2023

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“…The effects of H. pylori eradication on serum vitamin levels have aroused extensive interest. Several studies ( 2 , 57 – 59 ) found that patients that underwent successful H. pylori eradication had higher serum vitamin D levels than patients with in which eradication failed. Several studies ( 13 , 14 , 60 , 61 ) described vitamin B 12 level discrepancies before and after successful H. pylori eradication therapy; nevertheless, there were also inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai

Jin

et al. 2022

Front. Nutr.

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BackgroundOver recent decades, epidemiological studies have shown relationships between vitamins and Helicobacter pylori (H. pylori) infection and eradication, but the results are controversial.MethodsA comprehensive meta-analysis and systematic review were conducted to clarify the relationships between common types of vitamins and H. pylori. We applied meta-regression, subgroup analysis and sensitivity analysis to obtain available evidence. Articles published from January 1991 to June 2021 in PubMed, EMBASE, and the Cochrane Library were searched.ResultsIn total, we identified 48 studies. The results indicate that H. pylori -positive patients had lower serum vitamin B12 [standardized mean difference (SMD) = −0.30; 95% confidence interval (CI): −0.53 – −0.08], folate (SMD = −0.69; 95% CI: −1.34 – −0.04), vitamin C (SMD = −0.37; 95%CI: −0.57 – −0.18) and vitamin D (SMD = −0.34; 95% CI: −0.49 – −0.18) levels than H. pylori-negative patients. Patients in which H. pylori had been successfully eradicated had higher serum vitamin D levels (SMD = 1.37; 95% CI: 0.37–2.38) than in patients in which eradication had been unsuccessful. The serum vitamin B12 levels of H. pylori-positive patients improved after successful H. pylori eradication therapy (SMD = 1.85; 95% CI: 0.81–2.90), and antioxidant vitamin supplementation to an H. pylori eradication regimen improved the eradication rate (risk ratio = 1.22; 95% CI: 1.02–1.44 for per-protocol analysis; risk ratio = 1.25; 95% CI: 1.06–1.47 for intention-to-treat analysis).ConclusionsH. pylori infections decrease the serum levels of several types of vitamins, eradication of H. pylori could rescue its adverse effects, and antioxidant vitamin supplementation may improve the H. pylori eradication rate.Systematic Review Registrationidentifier: CRD42021268127.

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“…In China, there are also considerable regional disparities in the incidence of HP infection in children, with infection rates ranging from 30% to 60% ( 3 , 4 ). HP infection in children can affect their growth and development, nutritional metabolism, and autoimmune systems ( 5 ) and is related to 25-hydroxyvitamin D [25(OH)D] deficiency ( 6 ), which could be a risk factor for HP eradication failure ( 7 ). However, there are few studies on the correlation between the levels of 25(OH)D in children with different degrees of HP infection and immunity.…”

Section: Introductionmentioning

confidence: 99%

25-hydroxyvitamin D levels in children of different ages and with varying degrees of Helicobacter pylori infection and immunological features

Dai

Chu

et al. 2023

Front. Pediatr.

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BackgroundHelicobacter pylori (HP) is a major cause of upper digestive tract diseases. However, the relationship between HP infection and 25-hydroxyvitamin D [25(OH)D] levels in children has not been fully elucidated. This study investigated the levels of 25(OH)D in children of different ages and with varying degrees of HP infection and immunological features as well as the correlations between 25(OH)D levels in children infected with HP and their ages and degrees of infection.Materials and methodsNinety-four children who underwent upper digestive endoscopy were divided into an HP-positive group without peptic ulcers (Group A), an HP-positive group with peptic ulcers (Group B) and an HP-negative control group (Group C). The serum levels of 25(OH)D and immunoglobulin and the percentages of lymphocyte subsets were determined. HP colonization, the degree of inflammation, and the degree of activity were further evaluated by HE staining and immunohistochemical staining in gastric mucosal biopsy.ResultsThe 25(OH)D level of the HP-positive groups (50.93 ± 16.51 nmol/L) was significantly lower than that of the HP-negative group (62.89 ± 19.18 nmol/L). The 25(OH)D level of Group B (47.79 ± 14.79 nmol/L) was lower than that of Group A (51.53 ± 17.05 nmol/L) and was significantly lower than that of Group C (62.89 ± 19.18 nmol/L). The 25(OH)D level decreased with increasing age, and there was a significant difference between Group C subjects who were ≤5 years old and those who were aged 6–9 years and ≥10 years. The 25(OH)D level was negatively correlated with HP colonization (r = −0.411, P < 0.01) and the degree of inflammation (r = −0.456, P < 0.01). The percentages of lymphocyte subsets and immunoglobulin levels among Groups A, B and C were not significantly different.ConclusionsThe 25(OH)D level was negatively correlated with HP colonization and the degree of inflammation. As the age of the children increased, the level of 25(OH)D decreased, and the susceptibility to HP infection increased.

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Is Vitamin D Deficiency a Risk Factor for Helicobacter Pylori Eradication Failure?

Cited by 5 publications

References 0 publications

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

25-hydroxyvitamin D levels in children of different ages and with varying degrees of Helicobacter pylori infection and immunological features

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