Is total iron binding capacity (TIBC) calculation correct?

Rathnayake, Geetha; Badrick, Tony

doi:10.1016/j.pathol.2018.12.419

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Iron and its various forms, such as ferritin and total iron binding capacity (TIBC), are other indicators of ALS; many studies have shown that iron can be collected in the spinal cord and cerebrospinal fluid of ALS patients [26], as well as within the skeletal muscles in rat models with ALS [27], which can play a critical role in the central nervous system for various metabolic processes, notably oxidative phosphorylation, myelination, the production of neurotransmitters, and oxygen transport [28]. The ferritin storage form of iron can prevent iron from creating reactive oxygen species (ROS) [29], and in terms of TIBC, which indicates how much transferrin binds with Fe, an elevated level of transferrin occurs when the iron store (ferritin) is depleted, so TIBC increases in patients with an Fe level below the normal range [30].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patients’ Specific Immunological and Biochemical Biomarkers

Alkhazaali-Ali,

Sahab-Negah,

Boroumand

et al. 2024

Diseases

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Background: Amyotrophic lateral sclerosis (ALS) is an incurable disease. There are vigorous attempts to develop treatments to reduce the effects of this disease, and among these treatments is the transplantation of stem cells. This study aimed to retrospectively evaluate a mesenchymal stem cell (MSC) therapy cohort as a promising novel treatment modality by estimating some additional new parameters, such as immunological and biochemical factors. Methods: This study was designed as an open-label, one-arm cohort retrospective study to evaluate potential diagnostic biomarkers of repeated infusions of autologous-bone marrow-derived mesenchymal stem cells (BM-MSCs) in 15 confirmed patients with ALS, administered at a dose of 1 × 106 cells/kg BW with a one-month interval, in equal amounts in both an intravenous (IV) and intrathecal (IT) capacity simultaneously, via various biochemical (iron (Fe), ferritin, total-iron-binding capacity (TIBC), transferrin, and creatine kinase (CK)) and immunological parameters (tumor necrosis factor-alpha (TNF-α), neurofilament light chain (NFL), and glial-cell-derived neurotrophic factor (GDNF) levels, evaluated during the three-month follow-up period in serum and cerebrospinal fluid (CSF). Results: Our study indicated that, in the case of immunological biomarkers, TNF-α levels in the CSF showed a significant decrease at month three after transplantation compared with levels at month zero, and the p-value was p < 0.01. No statistically significant changes were observed for other immunological as well as biochemical parameters and a p-value of p > 0.05. Conclusions: These results can indicate the potential benefit of stem cell transfusion in patients with ALS and suggest some diagnostic biomarkers. Several studies are required to approve these results.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patients’ Specific Immunological and Biochemical Biomarkers

Alkhazaali-Ali,

Sahab-Negah,

Boroumand

et al. 2024

Diseases

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Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats

Mei

Huang

et al. 2021

Journal of Ethnopharmacology

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Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders

Semenova,

Bjørklund,

Butnariu

et al. 2024

CMC

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Background: Iron deficiency and iron-related disorders are common health issues worldwide, affecting a significant proportion of the population. Diagnosis and management of these disorders rely heavily on using various iron-related biomarkers that can provide valuable clinical information. Objective: This review article provides an overview of the most commonly used iron-related biomarkers, including serum ferritin, transferrin saturation, soluble transferrin receptor, zinc protoporphyrin, and free erythrocyte protoporphyrin. Other emerging biomarkers, such as hepcidin and retinol-binding protein 4, are also discussed. Results: Iron plays a vital role in various physiological processes, including oxygen transport, energy metabolism, and DNA synthesis. The article highlights the advantages and limitations of iron biomarkers and their clinical applications in diagnosing and managing iron deficiency and iron-related anemia. Conclusion: Using iron-related biomarkers in screening and monitoring programs can improve patient outcomes and reduce healthcare costs.

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Is total iron binding capacity (TIBC) calculation correct?

Cited by 4 publications

References 7 publications

Evaluation of the Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patients’ Specific Immunological and Biochemical Biomarkers

Evaluation of the Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patients’ Specific Immunological and Biochemical Biomarkers

Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats

Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders

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