Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats

Mei, Hao; Wu, N.; Huang, Xiao; Cui, Zheng H; Xu, Jingya; Yang, Xiaobing; Zeng, Fang; Wang, Kaiping

doi:10.1016/j.jep.2020.113448

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…First, SXN can promote hematopoiesis via different signaling pathways. Studies have demonstrated that SXN increased the synthesis of erythropoietin in rats, thereby ameliorating renal anemia in the animals ( Mei et al, 2021 ). Furthermore, SXN promoted the restoration of hemopoietic function in models of myelosuppression by enhancing the secretion of hematopoietic factors and activating the JAK2/STAT3 pathway ( Ding et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…SXN can also facilitate iron absorption by regulating iron metabolism. One study found that silkworm excrement extract can inhibit hepcidin expression by blocking the BMP6/SMAD4 and IL-6/STAT3 pathways in a rat model of renal anemia ( Mei et al, 2021 ). Similarly, Liu and Li (2020) reported that a SXN-containing regimen exerted therapeutic effects on IDA by inhibiting hepcidin expression and regulating iron metabolism.…”

Section: Discussionmentioning

confidence: 99%

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The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis

Zhang

Sun

et al. 2022

Front. Pharmacol.

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Background: Iron deficiency anemia (IDA) is a public health problem worldwide. Shengxuening Tablet (SXN) has been used for the treatment of various types of anemia, attaining high efficacy.Objective: To evaluate the safety of SXN as well as its preventive and therapeutic efficacy against IDA across different population groups.Methods: PubMed, Embase, Web of Science, the Cochrane Library, the China Knowledge Network, the China Biomedical Literature Database, the Wanfang Data Knowledge Service Platform, and the China Science and Technology Journal Database was searched for relevant clinical trials through June 2022 and a systematic review and meta-analysis of the identified studies was undertaken.Results: A total of 39 trials involving 4,562 cases were included in the meta-analysis. The total efficiency of SXN was superior than the control group in improving red blood cell (RBC) count [SMD = 1.31, 95% CI (0.7, 1.91), p < 0.0001], hemoglobin (Hb) [SMD = 1.11, 95% CI (0.75, 1.46), p < 0.00001], mean corpuscular volume (MCV) [SMD = 0.5, 95% CI (0.33, 0.68), p < 0.00001], total serum iron (SI) levels [SMD = 1.87, 95% CI (1.3, 2.44), p < 0.00001], and transferrin saturation (TSAT) levels [SMD = 2.07, 95% CI (1.86, 2.27), p < 0.00001]. Besides, the total effects of SXN to improve mean corpuscular hemoglobin (MCH) [SMD = 0.12, 95% CI (−0.16, 0.4), p = 0.41], mean corpuscular hemoglobin concentration (MCHC) [SMD = 0.03, 95% CI (−0.18, 0.24), p = 0.77], hematocrit (HCT) [SMD = 0.65, 95% CI (−0.25, 1.55), p = 0.16], and serum ferritin (SF) levels [SMD = 0.59, 95% CI (−0.67, 1.85), p = 0.36] and reduce the total iron binding capacity (TIBC) [SMD = 0.34, 95% CI (−0.07, 0.74), p = 0.1] was comparable to that of iron supplementation. SXN significantly raised the total effective rates of IDA [risk ratio (RR) = 1.06, 95% CI (1.02, 1.09), p = 0.0005] and was associated with fewer adverse events [RR = 0.24, 95% CI (0.18, 0.31), p < 0.00001], fewer adverse pregnancy outcomes [RR = 0.34, 95% CI (0.2, 0.57), p < 0.0001], and lower anemia recurrence rates during pregnancy [RR = 0.29, 95% CI (0.1, 0.84), p = 0.02]. Regarding prevention, the effects of SXN to maintain the RBC count, Hb level and other IDA-related parameters were comparable to that of control group and SXN reduced the risk of IDA incidence during pregnancy.Conclusion: SXN demonstrated promising efficacy in the treatment and prevention of IDA and outperformed routine iron formulations in terms of safety, thus rendering SXN a reliable treatment option for IDA.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier: CRD42022353247.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis

Zhang

Sun

et al. 2022

Front. Pharmacol.

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“…Since the publication of the Yellow Emperor’s Classic of Internal Medicine (“Huangdi Neijing” in Chinese) in the Han dynasty 1 , many classical medical books and pharmacopeia in China have contained the prescriptions and clinical application of medicines with complex sources 2 , 3 . Some medicines, such as Faeces Vespertilionis, Faeces Trogopterori 4 (the dry faeces of Trogopterus xanthipes Milne-Edwards, 1867), Faeces Leporum, Silkworm Faeces 5 (the dry faeces of Bombyx mori Linnaeus, 1758), and Cordyceps 6 (a complex mixture of Cordyceps sinensis (BerK.) Sacc.…”

Section: Introductionmentioning

confidence: 99%

Biological composition analysis of a natural medicine, Faeces Vespertilionis, with complex sources using DNA metabarcoding

Zhang

Wang

et al. 2022

Sci Rep

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Faeces Vespertilionis is a commonly used fecal traditional Chinese medicine. Traditionally, it is identified relying only on morphological characters. This poses a serious challenge to the composition analysis accuracy of this complex biological mixture. Thus, for quality control purposes, an accurate and effective method should be provided for taxonomic identification of Faeces Vespertilionis. In this study, 26 samples of Faeces Vespertilionis from ten provinces in China were tested using DNA metabarcoding. Seven operational taxonomic units (OTUs) were detected as belonging to bats. Among them, Hipposideros armiger (Hodgson, 1835) and Rhinolophus ferrumequinum (Schober and Grimmberger, 1997) were the main host sources of Faeces Vespertilionis samples, with average relative abundances of 59.3% and 24.1%, respectively. Biodiversity analysis showed that Diptera and Lepidoptera were the most frequently consumed insects. At the species level, 19 taxa were clearly identified. Overall, our study used DNA metabarcoding to analyze the biological composition of Faeces Vespertilionis, which provides a new idea for the quality control of this special traditional Chinese medicine.

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“…У науковій літературі [1,6] є дані щодо застосування екстракту лялечки дубового шовкопряда у тваринництві (свині, телиці), які підвищують інтенсивність росту та резистентність організму тварин. В останні роки з'явилась низка публікацій [4,5,7] щодо вивчення механізмів впливу екстрактів з відходів шовковичного виробництва (лялечки, фекалії) на організм тварин. У той же час у доступній нам літературі відсутні дані щодо біологічного впливу лялечки шовкопряда на гематологічні та біохімічні показники крові тварин.…”

unclassified

“…Так, було встановлено, що екстракт з лялечки шовкопряда знижує активність запальних процесів за рахунок зниження продукування прозапальних цитокінів (IL-1β, IL-4 TNF-α) та активізації протизапального Th-1опосередкованого IL-21 у мишей [5]. Екстракт фекалій шовкопряда регулював метаболізм заліза шляхом інгібування гепсидину і одночасно стимулював синтез еритропоетину для лікування ниркової анемії у щурів [7]. При дослідженні білкового складу лялечок шовковичного шовкопряда встановлено значну кількість класів білків, зокрема ферментів, які представляють великий інтерес для фармацевтичної промисловості, зокрема для застосування за серцевосудинних захворювань [4].…”

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Dynamics of non-specific humoral immunity factors in poultry which received feed supplement based on silkworm pupae

Stegniy

Kovalenko

Boiko

et al. 2021

Veterinary Medicine: Inter-Departmental Subject Scientific Collection

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The purpose of the study was to determine the focus and the intensity of the effect of the developed feed supplement based on the silkworm pupae on the nonspecific humoral immunity of poultry. The research was carried out on one-day-old broiler chickens, which were kept in standard vivarium conditions. The birds of first group were given the supplement in the morning, mixing with compound feed at the rate of 3.0 ml/kg of live weight. The second group was control. On the 20th, 27th, 34th and 48th days, 5 birds from each group were euthanized and blood was collected for clinical and biochemical studies. To determine the indicators of non-specific humoral immunity of birds after receiving feed supplement based on silkworm pupae in the blood serum of birds, the level of total protein, albumins, globulins, the concentration of circulating immune complexes of average molecular weight and seromucoids were determined by generally accepted methods. As a result of the use of a feed supplement based on silkworm pupae, there was determined an increase in the level of hemoglobin up to 16.0% and a slight activation of erythropoiesis, an increase in the level of humoral immunity, as evidenced by an increase in globulins up to 12.2% and circulating immune complexes up to 30.7%, and also inhibition of seromucoid synthesis by 15.4%. Thus, it has been concluded that the use of a feed supplement based on silkworm pupae allows to increase the level of non-specific humoral immunity of chickens, as evidenced by increased expression of its markers (globulins, circulating immune complexes), as well as inhibition of seromucoid synthesis. The revealed positive effect of the feed supplement based on silkworm pupae on the state of natural resistance can be considered as one of the factors of increasing the average daily weight gain of chickens by 39.0% in the first 7 days of life

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Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats

Cited by 6 publications

References 32 publications

The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis

The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis

Biological composition analysis of a natural medicine, Faeces Vespertilionis, with complex sources using DNA metabarcoding

Dynamics of non-specific humoral immunity factors in poultry which received feed supplement based on silkworm pupae

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