Is thyroid autoimmunity associated with gestational diabetes mellitus?

Thyroid antibodies and gestational diabetes mellitus: a meta-analysis

“…2). The meta-analysis of the 11 cohort studies (9,15,16,18,19,21,24,25,27,28) suggested that pregnant women with positive thyroid antibodies in the first trimester had no obvious risk of GDM compared with the reference group (pooled RR 1.07, 95% CI 0.96-1.19; Table 1; Fig. 2).…”

“…The prevalence of thyroid antibodies in pregnant women is approximately 10%-15% (8). In recent years, many epidemiologic studies have investigated the links between thyroid antibodies, including thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), and risk of GDM (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). However, these studies have apparently yielded conflicting results.…”

Thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus: a cross-sectional study

“…Montaner et al in their study reported 23 that 10% of their study's population had thyroid antibodies and 6.9% had GDM. Moreover, they did not observed significant association between existence of thyroid antibodies and incidence of gestational diabetes.…”

Evaluation of Thyroid Autoimmunity in Gestational Diabetes Mellitus

“…In our study 8.2% of the pregnant women were TPOAb positive. Montaner et al who found a 10% positivity for TPOAb [7]. They speculated that GDM would be the cause of thyroid autoimmunity.…”

“…In addition high titers of TPOAb have been found in pregnant women with gestational diabetes mellitus (GDM) [5]. Some studies have suggested that TPOAb positive pregnant women may have increased GDM risk [6] while other studies could not show this association [7][8][9]. Several studies found a higher prevalence of thyroid autoimmunity in GDM compared to healthy controls; therefore they suggest that it would be appropriate to extend screening for thyroid diseases to women with GDM [10].…”