Is There Right Hemisphere Dysfunction in Major Depression?

Ramos-Brieva, J.; Olivan, Jesus; Palomares, Anna Collado; Vela, A.

doi:10.3109/00207458408985351

Cited by 20 publications

(3 citation statements)

References 16 publications

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“…Contrary to our hypothesis, TRD patients did not show significant leftward line bisection errors in our study. Such a result is in line with previous studies, showing that the unipolar depressive patients displayed a non-significant leftward bias in manual line bisection, while schizophrenia patients bisected significantly leftward 47-49. However, results in regard to the hemispheric activation in the depressive disorder remain inconclusive up to date 50-55.…”

Section: Discussionsupporting

confidence: 91%

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

He¹,

Chai²,

Zhang³

et al. 2010

Int. J. Med. Sci.

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Background and Objectives The line bisection error to the left of the true center has been interpreted as a relative right hemisphere activation, which might relate to the subject's emotional state. Considering that patients with generalized anxiety disorder (GAD) or treatment-resistant depression (TRD) often have negative emotions, we hypothesized that these patients would bisect lines significantly leftward. Methods We tried the line bisection task in the right-handed healthy volunteers (n = 56), GAD (n = 47) and TRD outpatients (n = 52). Subjects also completed the Zuckerman - Kuhlman Personality Questionnaire, the Zuckerman Sensation Seeking Scales, and the Plutchik-van Praag Depression Inventory. Results GAD patients scored highest on the Neuroticism-Anxiety trait, TRD patients scored highest on depression, and both patients scored lower on the Sociability trait. Patients with GAD also bisected lines significantly leftward compared to the healthy subjects. The Frequency of the bisection error was negatively correlated with Disinhibition-Seeking in the healthy subjects, and with Total sensation-seeking and Experience-Seeking in GAD patients, while the Magnitude of the line bisection error was negatively correlated with depression in TRD patients. Conclusions The study suggests a stronger right hemispheric activation, a weaker left activation, or both in the GAD, instead of TRD patients.

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Section: Discussionsupporting

confidence: 91%

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

He¹,

Chai²,

Zhang³

et al. 2010

Int. J. Med. Sci.

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show abstract

“…As such, it may be tapping attentional processing, rather HEMISPATIAL BIASES 153 than spatial processing. Although a tendency to bisect a line to the left of center has been replicated for right-handed adults on both visual and tactile line-bisection tasks (Bowers & Heilman, 1980;Bradshaw, Nathan, Nettleton, Wilson, & Pierson, 1987;Bradshaw, Nettleton, Nathan, & Wilson, 1983, 1985Ramos-Brieva, Olivan, Palomares, & Vela, 1984;Scarisbrick, Tweedy, & Kuslansky, 1987;Schenkenberg, Bradford, & Ajax, 1980), lefthanders have been found to be even more left biased than right-handers (Scarisbrick et al, 1987). If the leftward bias resulted from right-hemisphere specialization for spatial processing, left-handers should have been less, rather than more left biased, because left-handers are less lateralized than right-handers.…”

mentioning

confidence: 91%

Hemispatial biases in children on the draw‐a‐person test

Heller

1991

Developmental Neuropsychology

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“…Using tachistoscopic presentation of happy-sad chimeric face drawings, David et al were able to show that while healthy controls and manic patients tend to have a leftward attentional bias (they tend to perceive the left hemi-face), depressed patients do not show this effect (David, 1993). Studies looking at the performance of depressed subjects bisecting horizontal lines presented on the right-left axis were inconclusive (Cavezian et al, 2007; Ramos-Brieva et al, 2009; Wei et al, 2010). To the best of our knowledge, there are no studies that looked at the vertical or the radial axes in subjects with depression.…”

Section: Introductionmentioning

confidence: 99%

Proximity Bias Following Affective Metaphors in Patients With Depression—Psychoanalytic Considerations

2019

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Background: Many languages use spatial metaphors to describe affective states such as an upward bias to denote positive mood, a downward bias to denote negative mood, a body proximity bias to denote personal relatedness concern, and a right-left bias to denote negative or positive valence. These biases might be related to experiential traces related to these affective states. If this is the case, depressed subjects would show either a downward spatial bias, a body proximity bias, or a right-left shift in attention. We evaluated the occurrence of such biases in subjects with depression compared to healthy controls.Methods: Subjects: 10 subjects with depression (5F:5M; age = 47.2 ± 15.2) and 10 healthy controls (5F:5M; age = 45.8 ± 14.5). Experimental task: line bisection task. Lines were presented in three spatial orientations [vertical (up-down), horizontal (right-left), radial (proximal-distal)] and were either blank, composed with words (negative/positive/neutral), or with smileys (negative/positive/neutral). There were 21 line types, and each was presented eight times, reaching a total of 168 lines.Results: Compared with healthy controls, subjects with depression bisected radial lines significantly closer to their body. There were no significant differences for either horizontal or vertical lines.Conclusion: The proximity spatial bias observed in subjects with depression suggests that depression might activate neural spatial networks. We argue that these networks could be dynamically activated through narcissistic mechanisms as implied in “Mourning and Melancholia” where Freud postulates a narcissistic mediated bias in depression according to which the depressed subjects withdraw from the outside world.

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Is There Right Hemisphere Dysfunction in Major Depression?

Cited by 20 publications

References 16 publications

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

Hemispatial biases in children on the draw‐a‐person test

Proximity Bias Following Affective Metaphors in Patients With Depression—Psychoanalytic Considerations

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