Is there crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis?

Do peak torque angles of muscles change following anterior cruciate ligament reconstruction using hamstring or patellar tendon graft?

“…[1] Past research has shown a significant postoperative deficit in isokinetic muscle test parameters such as peak muscle torque, total work and power which may lead to osteoarthritis. [2][3][4][5][6][7][8][9] These deficits were found to be associated with the location of the donor site. [10] Previous research has also focused specifically on the quality of torque production as demonstrated by isokinetic torque curve irregularities, curve fluctuations, a rapid downward slope pattern, and a concave pattern when viewed on a graph following ACL reconstruction.…”

Association between patellofemoral congruence and patellofemoral chondropathy in patients with anterior knee pain: A T2 mapping knee MRI study

“…Physiological thinning of the PFJ cartilage develops with older age, even in the absence of cartilage disease. [2][3][4] Atik et al, [3] showed that, due to reduced interstitial fluid content, the cartilage becomes harder with older age and less adaptive with various changes. Here, we recruited the control group from patients with a similar average age as the control group, so that the relationship between cartilage structure and morphology could be more reliably compared.…”

“…Any developmental or acquired difference in the surface geometry of the PFJ can cause a wide variety of clinical problems, such as chondromalacia patella and patellar instability. [2,3] Cartilage has been shown to increase water content in the presence of collagen, and collagen content is reduced by age or degeneration of the cartilage. [4] This relationship forms the basis of the T 2 mapping technique, in which T 2 relaxation time increases.…”

Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation?

“…[13] The self-repair capacity of cartilage is very limited. Besides, there is no admitted application or treatment protocol for present commercial drugs, and therefore different clinics use distinct treatment strategies.…”