Is There Correlation Between Helicobacter pylori and Enterohepatic Helicobacter Species With Gallstone Cholecystitis?

Fatemi, Seyed Masih; Doosti, Abbas; Shokri, Dariush; Ghorbani-Danili, Sadegh; Molazadeh, Morteza; Tavakoli, Hossein; Minakari, Mohammad; Tavakkoli, Hamid

doi:10.14309/00000434-201710001-00061

Cited by 7 publications

(9 citation statements)

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“…Therefore, a series of studies have been carried out to find the relationship between gallbladder H. pylori infection and chronic cholecystitis/cholelithiasis [ 15 – 34 ]. Karagin et al [ 28 ] supported the role of H. pylori in the development of cholecystitis in humans.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

Wang

Chen

Jiang

et al. 2021

Canadian Journal of Gastroenterology and Hepatology

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Helicobacter pylori (H. pylori) is proved to be the main pathogenic agent of various diseases, including chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In addition, chronic cholecystitis and cholelithiasis are common worldwide, which are supposed to increase the total mortality of patients. Epidemiologic evidence on the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis still remains unclear. We conducted a systematic review and meta-analysis of overall studies to investigate the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis. Two researchers searched PubMed, Embase, and Cochrane Library databases to obtain all related and eligible studies published before July 2020. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by the random-effects model. Subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also conducted. Twenty studies were included in the meta-analysis, involving 1735 participants and 1197 patients with chronic cholecystitis/cholelithiasis. Helicobacter species infection of the gallbladder was positively correlated with increased risk of chronic cholecystitis and cholelithiasis, especially H. pylori (OR = 3.05; 95% CI, 1.81–5.14; I2 = 23.5%). Besides, country-based subgroup analysis also showed a positive correlation between the gallbladder H. pylori positivity and chronic cholecystitis/cholelithiasis risk. For Asian and non-Asian country studies, the ORs were 4.30 (95% CI, 1.76–10.50; I2 = 37.4%) and 2.13 (95% CI, 1.23–3.70; I2 = 0.0%), respectively. The association was more obvious using the bile sample and urease gene primer. In conclusion, this meta-analysis provided evidence that there is a positive correlation between H. pylori infection in the gallbladder and increased risk of chronic cholecystitis and cholelithiasis.

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Section: Introductionmentioning

confidence: 99%

The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

Wang

Chen

Jiang

et al. 2021

Canadian Journal of Gastroenterology and Hepatology

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“…H. pylori was observed at a significantly higher rate in cases with acute cholecystitis associated with gallstones compared with the other cases, and there was no relationship with other Helicobacter strains. 16 A metaanalysis that reviewed studies of the relationship between H. pylori and gallstones and cholecystectomy reported that H. pylori was more common in patients with chronic cholecystitis and gallstones compared with the control group (24.98% vs. 8.28%, P<0.05). 17 Another meta-analysis also demonstrated a relationship between H. pylori in the gallbladder and cholelithiasis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Arı¹,

Tatar²,

Yarıkkaya³

2019

J Int Med Res

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ObjectiveHelicobacter pylori commonly occurs in the stomach, but localizations outside the stomach and related diseases have also been investigated. However, the relationship between H. pylori and gallstones remains controversial. We aimed to investigate the relationships between H. pylori in the stomach and the gallbladder and gallstones.MethodsThis prospective case-control study included patients who underwent cholecystectomy because of gallstones, pancreatic head cancer, or hepatic resection. The patients were separated into two groups according to the detection of H. pylori in gallbladder samples using Giemsa staining. Stomach H. pylori status was based on previous gastroscopy.ResultsThe study enrolled 60 patients, comprising 27 patients with gallstones and 33 without. There was no significant difference in the incidence of gallstones between patients with or without H. pylori in the stomach or gallbladder. Furthermore, the presence of H. pylori in the stomach was measured in 14 patients and was significantly correlated with H. pylori in the gallbladder.ConclusionThe current study showed no relationship between the occurrence of gallstones and the presence of H. pylori in either the gallbladder or the stomach. In contrast to previous reports, this suggests that H. pylori does not play a role in the development of gallstones.

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“…In recent years, many scholars at home and abroad have verified the existence and role of bacteria in cholesterol gallstones through experiments. Fatemi et al [32] found a link between Helicobacter pylori and acute gallstones. Yang Yulong et al [33] observed 15 cases of cholesterol stones by electron microscopy, and 10 of them found bacteria in the surface structure of stones.…”

Section: Bile Bacterial Infectionmentioning

confidence: 99%

Advances in Research on the Pathogenesis of Type 2 Diabetes Complicated with Gallstone

Tan¹,

Kou²

2019

IJCM

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At present, the incidence of diabetes complicated with gallstones is increasing rapidly, and there are still many problems in the pathogenesis of the disease. Diabetes complicated with gallstones is a chronic complication of diabetes, with diabetes-induced hyperinsulinemia and insulin resistance, gallbladder emptying disorders, Oddis sphincter dysfunction, gastrointestinal hormone disorders, gastrointestinal dyskinesia, fat metabolism disorders, bile Bacterial infection and other factors are related. In recent years, it has been found that in diabetic patients, Telocytes (TC) and Cajal interstitial cells (ICC) are reduced in the biliary system. In addition, the contact between ICC cells and smooth muscle cells and nerve endings is significantly reduced, so it is considered that bile Stone formation has a certain relationship with TC and ICC reduction. This article reviews recent research progress.

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Is There Correlation Between Helicobacter pylori and Enterohepatic Helicobacter Species With Gallstone Cholecystitis?

Cited by 7 publications

References 0 publications

The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Advances in Research on the Pathogenesis of Type 2 Diabetes Complicated with Gallstone

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