Is There Any Species Specificity in Infections with Aquatic Animal Herpesviruses?–The Koi Herpesvirus (KHV): An Alloherpesvirus Model

Bergmann, Sven; Cieslak, Michael

doi:10.4172/2150-3508.1000169

Cited by 8 publications

(12 citation statements)

References 31 publications

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“…For some fish it has been proven by cohabitation with common carp or koi that the virus is released infectious to other fish. Those fish are e. rainbow trout (Oncorhynchus mykiss) (Bergmann et al 2016).…”

Section: Hosts Susceptible To Khvmentioning

confidence: 99%

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Koi herpesvirus (KHV) and KHV disease (KHVD) – a recently updated overview

et al. 2020

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Over the last years, there has been an enormous increase in the knowledge on koi herpesvirus (KHV), koi herpesvirus disease (KHVD), pathogenesis and virus variants. Different KHV lineages have clearly been identified, possible genomic changes during replication in different cell cultures at different temperatures but also in several hosts have been identified, a persistent stage of infection has been specified and it has been shown that infection with KHV is not host specific at all, but KHVD is. Additionally, it has been shown that it is possible to combat KHVD by immunization with inactivated and attenuated live vaccines using different delivery systems but also to benefit from alternative treatments with e.g. exopolysaccharids obtained from Arthrospira platensis.

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Section: Hosts Susceptible To Khvmentioning

confidence: 99%

“…It seems that in the aquatic environment there is no species specificity for herpesviruses but for the occurrence of the disease in one species (Bergmann et al 2016).…”

Section: Hosts Susceptible To Khvmentioning

confidence: 99%

Koi herpesvirus (KHV) and KHV disease (KHVD) – a recently updated overview

et al. 2020

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“…In contrast to previous findings stating that tilapia cannot be infected with or resistant to KHV utilizing PCR method (Perelberg et al 2003;Dishon et al 2005;Yuasa et al 2009), the result from observation using molecular assay on the organs indicates that tilapia was infected by KHV. It was also confirmed by Bergmann et al (2016) that in addition to Cyprinidae, NTS fish can also be infected with KHV. Although PCR method has a high sensitivity and specificity, but the results are less reliable because often the virus is in a carrier condition (Azila et al 2012) and the primary PCR limit detection used in this study is only able to detect 10 fg (fentogram) of KHV DNA or 30 virion particles (Bercovier et al 2005).…”

Section: Discussionmentioning

confidence: 71%

“…Although PCR method has a high sensitivity and specificity, but the results are less reliable because often the virus is in a carrier condition (Azila et al 2012) and the primary PCR limit detection used in this study is only able to detect 10 fg (fentogram) of KHV DNA or 30 virion particles (Bercovier et al 2005). KHV detection is recommended to be performed simultaneously between molecular and serological methods to support each other's specificity (Dishon et al 2005;Eide et al 2011;Bergmann et al 2016;Li et al 2017).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to NTS, a study has been conducted to investigate the susceptibility of hybrid fish (Hedrick et al 2006;Bergmann et al 2010); it shows that hybrids are susceptible to KHV infection and are potentially a carrier. Associated with the carrier potential possessed by hybrid fish, rainbow trout also has potential as a KHV carrier (Bergmann et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Pathognomonic features and ultrastructural of Koi Herpesvirus infected Oreochromis niloticus

et al. 2019

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Abstract. Wahidi BR, Yanuhar U, Fadjar M, Andayani A. 2019. Pathognomonic features and ultrastructural of Koi Herpesvirus infected Oreochromis niloticus. Biodiversitas 20: 497-503. Koi Herpesvirus (KHV) has caused considerable losses in the cultivation of the Cyprinidae family worldwide. In addition to infecting Cyprinidae, KHV can also infect other freshwater fish. This study reports histopathology and ultrastructural analysis of KHV that infect Nile tilapia. Although there are no specific clinical symptoms, pathognomonic indicating Nile tilapia fish has been infected with KHV have been found, i.e. through the formation of intranuclear inclusion body and cell swelling which essentially experience chromatin margination. In addition, histopathology results indicate changes or damage to other tilapia tissue, i.e. necrosis, hypertrophy, edema, hemorrhage, inflammation, congestion, degeneration, and apoptosis. These results indicate that KHV has been distributed and replicated in tilapia organs. Based on the Transmission Electron Microscopy (TEM) analysis, KHV virions have been detected in the cytoplasm or outside the cells on a size of 150-170 nm.

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