Is there any relationship between decreased AgNOR protein synthesis and human hair loss?

Abstract

Argyrophilic nucleolar organizing region associated proteins (AgNORs) play roles in cell proliferation and a variety of diseases. We attempted to determine whether decreased NOR protein synthesis causes human hair loss. We studied 21 healthy males who suffered hair loss on the frontal/vertex portion of the head. Hair root cells from normal and hair loss sites were stained for AgNOR. One hundred nuclei per site were evaluated and the AgNOR number and NORa/TNa proportions of individual cells were determined using a computer program. The cells from normal sites had significantly higher AgNOR counts than those from hair loss sites. Also, the cells from the normal sites had significantly higher NORa/TNa than cells from the hair loss sites. In the normal sites, the cells demonstrated more NOR protein synthesis than cells in hair loss sites. Therefore, decreased NOR protein synthesis appears to be related to hair loss in humans.

Nuclear AgNOR protein enhancement in nucleoplasms of peripheral blood lymphocytes of babies/children with down syndrome

“…Morphometric analysis of AgNOR proteins in interphase in cancer cells has been used to identify various benign and malignant lesions, to establish prognoses, and to determine the proliferative activity of cells (Cucer et al, ; Derenzini et al, ; Eroz et al, ). In recent studies, morphometric analysis of AgNOR protein quantity has been also used to evaluate cellular activity in other cell types such as hair root cells of human (Eroz et al, ).…”

Argyrophilic nucleolar organizing regions in patients with Xeroderma Pigmentosum Group E

“…Various studies have been conducted regarding the significance of the interphase argyrophilic Nucleolar organizing region-associated protein (AgNOR) quantity in different cells. [3][4][5][6][7][8][9] AgNOR proteins help distinguish between malignant and benign cells and provide information regarding the proliferative and metabolic activities of the cells. This study was conducted to understand whether the AgNOR method could be used to differentiate individuals with XP-E from normal individuals and whether the AgNOR method could be helpful in the differential diagnosis of individuals with (homozygous and heterozygous) and without DDB2 gene mutation that causes XP-E. To our knowledge, no study in the literature has evaluated the mean AgNOR number and the total AgNOR area-to-total nuclear area (TAA/TNA) ratio in individuals with XP-E.…”

“…Nucleolar organizer regions (NORs) are sites of the ribosomal genes composed of ribosomal DNA (rDNA) and proteins. Various studies have been conducted regarding the significance of the interphase argyrophilic Nucleolar organizing region–associated protein (AgNOR) quantity in different cells 3–9 . AgNOR proteins help distinguish between malignant and benign cells and provide information regarding the proliferative and metabolic activities of the cells.…”

May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

“…Thus, those proteins are referred to as argyrophilic NOR-associated proteins (AgNORs), while the silver-staining method is the most reliable to show nucleoli during the interphase (24). Numerous studies have been carried out on the importance of the interphase quantity of AgNOR proteins in hair root cells of humans (25,26), buccal epithelial and blood cells of Down syndrome infants and healthy persons (27)(28)(29), possible effects of carbonmonoxide (CO) exposure on the AgNOR protein synthesis of the cells of the heart, lung and femoral muscle (30)(31)(32)(33) and ischemia/reperfusion injury (34). However, to our knowledge, there is no study about the relation between AgNOR proteins and the effects of rhamnetin exposure on EST in literature.…”