Argyrophilic nucleolar organizing regions in patients with Xeroderma Pigmentosum Group E

Karagün, Ebru; Eröz, Recep

doi:10.1111/exd.14238

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Both nucleolin (NCL) and nucleophosmin (NPM1 are AgNOR proteins. The studies about the use of these protein as biomarkers in xeroderma pigmentosum group E (18), hypoxic damage caused by testicular torsion (19), different doses of carbon monoxide poisoning in brain (20) and both heart tissue (21, 22) and lung (23), ST-elevation myocardial infarction (24), clinical exacerbation of chronic obstructive pulmonary disease (25), colon adenocarcinoma (26), Ehrlich's ascitic carcinoma (27,28), oncocytology (29), fine-needle aspiration samples of thyroid (30), cytologic discrimination of follicular thyroid lesions (31), discrimination of benign thyroid nodules and normal thyroid tissue (32) in nondiagnostic fine needle aspiration samples (due to insufficient cell groups) of thyroid nodules (33), comparison of fine needle aspiration biopsy and paraffin embedded tissue sections (34), renal ischemia/ reperfusion (I/R) injury (35), hair root cells of humans at different developmental stages and sex (36), human hair loss (37,38), buccal epithelial cells of healthy individuals (39), developmental stages of Down syndrome infants (40), peripheral blood lymphocytes of babies/children with Down syndrome (41), wound healing (42) etc. were done.…”

Section: Discussionmentioning

confidence: 99%

Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?

Akın¹,

Eşbah²,

Eröz³

2022

Acta fac medic Naissensis

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Aim: Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. Materials and Method: NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of chemotherapy from the control group and the patients diagnosed with lung cancer were studied using ELISA method. Results: Serum NCL and NPM1 levels of the patients were higher than of the controls (p = 0.085 for NCL, p = 0.000 for NPM1). NCL and NPM1 levels by histopathologic type were significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.05 for each). In view of the treatment responses to chemotherapeutic agents, there was a statistically insignificant difference between the values before and after chemotherapy (p > 0.05 for each). Conclusion: High serum NCL and NPM1 levels were found to correlate with poor prognosis, poor treatment response and low survival rate. It can be concluded that serum NCL and NPM1 levels in lung cancer can be used as diagnostic and prognostic markers for the disease.

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Section: Discussionmentioning

confidence: 99%

Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?

Akın¹,

Eşbah²,

Eröz³

2022

Acta fac medic Naissensis

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“…The most common of these substitution mutations are found in exon 7 of the DDB2 gene (refer to Table 1 for further detail) [51][52][53][54][55][56][57][58][59][60]. Ebru found that changes in the shape, distribution, and quantity of argyrophilic nucleolar organizing region-associated protein (AgNOR) can provide information about the diagnosis and prognosis of patients with XPE, thereby guiding physicians regarding effective treatment strategies [61].…”

Section: Xpe and Skin Cancermentioning

confidence: 99%

A protein with broad functions: damage-specific DNA-binding protein 2

2022

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Damage-specific DNA-binding protein 2 (DDB2) was initially identified as a component of the damage-specific DNA-binding heterodimeric complex, which cooperates with other proteins to repair UV-induced DNA damage. DDB2 is involved in the occurrence and development of cancer by affecting nucleotide excision repair (NER), cell apoptosis, and premature senescence. DDB2 also affects the sensitivity of cancer cells to radiotherapy and chemotherapy. In addition, a recent study found that DDB2 is a pathogenic gene for hepatitis and encephalitis. In recent years, there have been few relevant literature reports on DDB2, so there is still room for further research about it. In this paper, the molecular mechanisms of different biological processes involving DDB2 are reviewed in detail to provide theoretical support for research on drugs that can target DDB2.

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“…Different studies were done about the using of AgNOR as a biomarkers in Xeroderma Pigmentosum Group E [8], testicular torsion [9], different doses of CO poisoning in brain [10], wound healing [11], ST segment elevation myocardial infarction [12], clinical exacerbation of chronic obstructive pulmonary disease [13], comparison of FNAB and paraffin embedded tissue sections [14], renal ischemia / reperfusion (I/R) injury [15], hair root cells of humans [16,17], buccal epithelial cells of healthy individuals [18], developmental stages of Down syndrome infants [19], discrimination of benign from malign thyroid tissues [20] etc. Also we showed that the both AgNOR sizes and numbers may be used as a marker for detection of the most reliable dose of rhamnetin [21], curcumin [22] and capsaicin [23].…”

Section: Introductionmentioning

confidence: 99%

Detection of Brain Tissue Damage in CO Poisoning with a New Method

Özbay¹,

Ayan²,

Eröz³

et al. 2023

Preprint

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We aimed to evaluate the effect of hypoxia caused by different levels of chronic carbon monoxide (CO) exposure via total AgNOR area/total nuclear area (TAA/TNA) ratio and mean AgNOR number on rat brain tissue. Eighteen Albino Wistar adult male rats were randomly divided into three groups (control as group A, 1000ppm and 3000ppm concentration of CO gas exposed as group B and C, respectively). CO gas was chronically given as 30 min a day during seven days. Statistically significant differences were found among the groups for both mean AgNOR number (χ2=12.051, p=0.002) and TAA/TNA (χ2=12.316, p=0.002), respectively. When the two groups are compared in terms of TAA/TNA ratio, statistically significant differences were detected between control and 1000ppm (Z=-2.882, p=0.004), between control and 3000 ppm (Z=-2.882, p=0.004) for TAA/TNA ratio. Statistically significant differences were found between control and 1000 ppm (Z=-2.882, p=0.004), between control and 3000 ppm (Z=-2.887, p=0.004) for mean AgNOR number. It is important to determine new markers with high sensitivity and easy to apply in order to determine the effect of toxication in different organs and tissues (especially brain tissues) that are chronically exposed to carbon monoxide intoxication. It seems that AgNOR may be used for this purpose.

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Argyrophilic nucleolar organizing regions in patients with Xeroderma Pigmentosum Group E

Cited by 5 publications

References 8 publications

Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?

Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?

A protein with broad functions: damage-specific DNA-binding protein 2

Detection of Brain Tissue Damage in CO Poisoning with a New Method

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