2022
DOI: 10.1007/s11033-022-07963-4
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A protein with broad functions: damage-specific DNA-binding protein 2

Abstract: Damage-specific DNA-binding protein 2 (DDB2) was initially identified as a component of the damage-specific DNA-binding heterodimeric complex, which cooperates with other proteins to repair UV-induced DNA damage. DDB2 is involved in the occurrence and development of cancer by affecting nucleotide excision repair (NER), cell apoptosis, and premature senescence. DDB2 also affects the sensitivity of cancer cells to radiotherapy and chemotherapy. In addition, a recent study found that DDB2 is a pathogenic gene for… Show more

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Cited by 8 publications
(2 citation statements)
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“…DDB2 is another crucial DNA damage response protein that recognizes many types of DNA damage [ 48 ]. After binding to the site of DNA damage, DDB2 forms a complex with CUL4A-DDB1, which ubiquitinates DDB2, causing it to dissociate from the DNA and allow repair complexes to access the site of DNA damage [ 49 ].…”
Section: Discussionmentioning
confidence: 99%
“…DDB2 is another crucial DNA damage response protein that recognizes many types of DNA damage [ 48 ]. After binding to the site of DNA damage, DDB2 forms a complex with CUL4A-DDB1, which ubiquitinates DDB2, causing it to dissociate from the DNA and allow repair complexes to access the site of DNA damage [ 49 ].…”
Section: Discussionmentioning
confidence: 99%
“…Alpha-actinin 1 (ACTN1) is a cross-linking cytoskeletal protein that has been associated with stress-induced cellular senescence 13 . Damage-speci c DNA-binding Protein 2 (DDB2) is a DNA lesion recognizing subunit for facilitation of nucleotide excision repair, which has also been implicated in mediation of apoptosis and premature senescence 14 . Ferredoxin Reductase (FDXR) is a mitochondrial avoprotein essential for electron transport that modulates in p53-dependent apoptosis via the production of reactive oxygen species in the mitochondria 15,16 .…”
Section: Introductionmentioning
confidence: 99%