A protein with broad functions: damage-specific DNA-binding protein 2

Abstract

Damage-specific DNA-binding protein 2 (DDB2) was initially identified as a component of the damage-specific DNA-binding heterodimeric complex, which cooperates with other proteins to repair UV-induced DNA damage. DDB2 is involved in the occurrence and development of cancer by affecting nucleotide excision repair (NER), cell apoptosis, and premature senescence. DDB2 also affects the sensitivity of cancer cells to radiotherapy and chemotherapy. In addition, a recent study found that DDB2 is a pathogenic gene for hepatitis and encephalitis. In recent years, there have been few relevant literature reports on DDB2, so there is still room for further research about it. In this paper, the molecular mechanisms of different biological processes involving DDB2 are reviewed in detail to provide theoretical support for research on drugs that can target DDB2.

Validation of protein biomarker panel in peripheral blood leukocytes of juvenile and adult C57BL/6 mice up to seven days post-exposure for machine learning-based radiation biodosimetry

“…Alpha-actinin 1 (ACTN1) is a cross-linking cytoskeletal protein that has been associated with stress-induced cellular senescence 13 . Damage-speci c DNA-binding Protein 2 (DDB2) is a DNA lesion recognizing subunit for facilitation of nucleotide excision repair, which has also been implicated in mediation of apoptosis and premature senescence 14 . Ferredoxin Reductase (FDXR) is a mitochondrial avoprotein essential for electron transport that modulates in p53-dependent apoptosis via the production of reactive oxygen species in the mitochondria 15,16 .…”