Is there any correlation between sperm parameters and chromatin quality with embryo morphokinetics in patients with male infertility?

Mangoli, Esmat; Khalili, Mohammad Ali; Talebi, Ali Reza; Ghasemi-Esmailabad, Saeed; Hosseini, Abdolkarim

doi:10.1111/and.12997

Cited by 27 publications

(35 citation statements)

References 29 publications

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“…Abnormal sperm parameters and chromatin alteration affect the normal embryo kinetics in ICSI program. Several studies have examined the morphokinetic development of embryos in SMF cases [33][34][35][36][37]7]. We, too, evaluated the morphokinetic development of embryos, but, in addition, investigated any possible correlation between morphokinetics and chromosomal status in SMF cases.…”

Section: Discussionmentioning

confidence: 99%

High rates of aneuploidy, mosaicism and abnormal morphokinetic development in cases with low sperm concentration

Kahraman

Sahin

Yelke

et al. 2020

J Assist Reprod Genet

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The aim of our study was to evaluate the impact of severe male infertility (SMF) on the chromosomal status of embryos and any possible correlation between chromosomal status and embryo morphokinetics in younger women using data obtained from comprehensive preimplantation genetic tests. Methods The trial was conducted in an ART and Reproductive Genetics Centre between 2011 and 2018. A total of 326 cycles in cases with SMF where the female partner's age was ≤ 35 years were evaluated. SMF is defined as sperm concentration below 5 mil/ml (million per milliliter) and divided into three subgroups according to sperm concentrations: 1-5 mil/ml, < 1mil/ml and testicular sperm. The control group of 190 cycles had normal sperm parameters. Results Significantly lower chromosomal euploidy rates were found in the testicular sperm group compared with the normal sperm controls when the female age was ≤ 35 years. In SMF, statistically significantly affected chromosomes were 2, 10, 11, 17, 21 and sex chromosomes. The mosaicism and abnormal morphokinetic development rates were higher in the SMF group than in control group, and this difference was significant when testicular sperm was used. Conclusion Lower euploidy rates, higher mosaicism rates and a higher incidence of abnormal morphokinetic development were observed in cases with testicular sperm with female partners ≤ 35 years compared with normal sperm controls. These findings suggest that PGT-A may be advisable in severe male infertility cases. Furthermore, the correlation between morphokinetics and chromosomal status was greatly reduced or absent in these most severe forms of male infertility, thus the need for new morphokinetic models.

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Section: Discussionmentioning

confidence: 99%

High rates of aneuploidy, mosaicism and abnormal morphokinetic development in cases with low sperm concentration

Kahraman

Sahin

Yelke

et al. 2020

J Assist Reprod Genet

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“…Stimulation protocol was performed as described before by using agonist or antagonist of gonadotrophin‐releasing hormone (GnRH) and FSH (Gonal F;Serono; Mangoli et al, ). Stimulation procedures were similar during the period of study.…”

Section: Methodsmentioning

confidence: 99%

“…The implantation rate (IR) was the fraction among the numbers of gestational sacs and the sum of transferred embryos. Moreover, the clinical pregnancy was defined once a gestational sac with foetal heartbeat was obvious in ultrasound checkup after 6 weeks of gestation, and the live birth rate (LBR) was the percentage among the numeral of live births and the total of embryos transferred (Goswami, Sharma, Jugga, & Gouri, ; Mangoli et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, one meta‐analysis revealed that the IMSI technique is related to better embryo quality, implantation and pregnancy rates, as well as lowering miscarriage rates in cases with male factor and prior ICSI failures (Setti et al, ). In addition, one of the main challenges in the ART program is the best embryo(s) selection for transfer (Faramarzi, Khalili, Agha‐Rahimi, & Omidi, ; Mangoli, Khalili, Talebi, Ghasemi‐Esmailabad, & Hosseini, ). Evaluation of the embryo kinetic at the early cleavage boosted prediction of implantation probable.…”

Section: Introductionmentioning

confidence: 99%

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IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility

et al. 2019

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Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time‐lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p < 0.05). In IMSI group, there were no differences in the TLM parameters among different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.

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“…However, decreased TQE developed on day 3 in the rescue ICSI group, with a similar number of oocytes retrieved compared with the conventional ICSI group. The influence of different semen parameters between rescue ICSI and conventional ICSI group was not considered in previous study [15], although they probably affect the embryo development [20,21] and chromosomal status [22]. Our current knowledge indicates that an oocyte in the fallopian tube after ovulation loses activity gradually if fertilization does not occur within 48 h. The process is similar in vitro, with an oocyte aging if it is not fertilized by spermatozoa and progressed to the cleavage stage [23].…”

Section: Discussionmentioning

confidence: 84%

Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection: a retrospective 6-year study

Xiong

Sun

et al. 2020

BMC Pregnancy Childbirth

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Background: Early rescue intracytoplasmic sperm injection (ICSI) has been used in clinic as appropriate currently. While the outcomes of children born after this method were not well assessed. The purpose of this study was to evaluate the effect of early rescue ICSI on women with primary infertility. Methods: Fresh embryo transfer cycles after rescue (n = 214) and conventional (n = 546) ICSI were retrospectively evaluated from women with primary infertility who underwent their first assisted reproductive technology cycles at our center in 2012-2017. The conventional ICSI group was subdivided into ICSI-1 (semen suitable for in vitro fertilization, IVF) and ICSI-2 (poor semen quality) to minimize bias from differences in semen quality. Pregnancy, delivery and neonatal outcomes were compared between groups. Results: There was a higher rate of polyspermy and a lower rate of top-quality embryos (TQE) on day 3 for oocytes subject to rescue ICSI compared with conventional ICSI. This reduced the total number of TQE and the number of TQE transferred in the rescue ICSI group. There was no significant difference between groups in clinical pregnancy, ongoing pregnancy, early miscarriage and live birth. For pregnant women, gestational age, route of delivery, risk of preterm birth and gestational diabetes mellitus were also comparable. Neonatal outcomes including sex ratio, birth weight, neonatal intensive care unit admission and birth defects were also similar after rescue and conventional ICSI. Moreover, no differences were observed with the different ICSI subgroups. Conclusions: For women with primary infertility who have a high risk of IVF fertilization failure (FF), rescue ICSI provides a safe and efficient alternative to minimize FF after initial IVF, but results in fewer TQE on day 3.

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Is there any correlation between sperm parameters and chromatin quality with embryo morphokinetics in patients with male infertility?

Cited by 27 publications

References 29 publications

High rates of aneuploidy, mosaicism and abnormal morphokinetic development in cases with low sperm concentration

High rates of aneuploidy, mosaicism and abnormal morphokinetic development in cases with low sperm concentration

IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility

Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection: a retrospective 6-year study

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