Is there any barrier impairment in sensitive skin?: a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves

Pinto, Pedro Contreiras; Rosado, Catarina; Parreirão, Catarina; Rodrigues, Luís Monteiro

doi:10.1111/j.1600-0846.2010.00478.x

Cited by 68 publications

(76 citation statements)

References 30 publications

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“…Most studies observed higher TEWL in the unchallenged skin of subjects with sensitive skin compared to those with nonsensitive skin [20,41,48,49] and in stingers compared to nonstingers [39,40,41,50,51], while only 2 studies identified significantly higher TEWL in sensitive skin [40,41]. Moreover, higher TEWL at baseline seems to correlate with a stronger TEWL increase following provocation [40]: plastic occlusion resulted in a significantly longer evaporation half-life time in subjects with sensitive skin [49], and a trend to increased recovery time of TEWL following SLS stimulation was also observed [20]. A stronger increase of TEWL was also found following SLS provocation both in sensitive versus nonsensitive atopic skin [52] and in a population of Japanese versus German women [53].…”

Section: Resultsmentioning

confidence: 99%

“…Individuals with sensitive skin frequently report reddening of their skin [15,35,37,38,43,44,49,57,58]. Therefore, the assessment of erythema in skin irritation has been widely investigated, either by visual assessment [28,37,41,59,60] or by quantitative methods such as tristimulus reflectance colorimetry (a* value) [20,50,51,52], reflectance spectrophotometry (erythema index) [38,53,59] or laser Doppler flowmetry (cutaneous blood flow) [20,41,48,50,51,53,61].…”

Section: Resultsmentioning

confidence: 99%

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What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

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Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701 articles which we appraised in detail. Impaired skin barrier function and increased vascular reactivity are most often associated with sensitive skin. We identified key reasons causing an ambiguity around the sensitive skin phenomenon. We propose using standardized selection methods of subjects by a multifactorial questionnaire spanning a range of provocations, including those of chemical, mechanical and environmental origin, followed by clinical, histological and top-notch biophysical measurements. This could lead to a breakthrough in the understanding of the sensitive skin phenomenon, fueling advances of biomedical and dermatological science. © 2014 S. Karger AG, Basel

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

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“…Sensitive skin (SS) is a condition characterized by the perception of skin discomfort following mild stimuli, frequently without objective signs of skin irritation [13,14,15,16,17,18]. This skin condition has been shown to be highly prevalent in the Western World but, despite extensive research in the past years, no consensus on its definition and pathomechanisms has been reached [19].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy

Richters

Falcone

Uzunbajakava

et al. 2017

Skin Pharmacol Physiol

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Background/Aims: Sensitive skin (SS), a frequently reported condition in the Western world, has been suggested to be underlined by an impaired skin barrier. The aim of this study was to investigate the skin barrier molecular composition in SS subjects using confocal Raman microspectroscopy (CRS), and to compare it with that of non-SS (NSS) individuals as well as atopic dermatitis (AD) and allergic rhinoconjunctivitis (AR) subjects, who frequently report SS. Methods: Subjects with SS (n = 29), NSS (n = 30), AD (n = 11), and AR (n = 27) were included. Stratum corneum (SC) thickness, water, ceramides/fatty acids, and natural moisturizing factor (NMF) were measured by CRS along with transepidermal water loss and capacitance on the ventral forearm, thenar, and cheek. Sebum levels were additionally measured on the forearm and cheek. Results: No differences between SS and NSS subjects were found regarding SC thickness, water, and NMF content, yet a trend towards lower ceramides/fatty acids was observed in the cheek. Compared to AD subjects, the SS group showed higher ceramides/fatty acid content in the forearm, whereas no differences emerged with AR. The correlation of macroscopic biophysical techniques and CRS was weak,yetCRS confirmed the well-known lower content of NMF and water, and thinner SC in subjects with filaggrin mutations. Conclusion: The skin barrier in SS is not impaired in terms of SC thickness, water, NMF, and ceramides/fatty acid content. The failure of biophysical techniques to follow alterations in the molecular composition of the skin barrier revealed by CRS emphasizes a strong need in sensitive and specific tools for in vivo skin barrier analysis.

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“…Portanto, uma pele saudável tende a possuir valores de PTEA mais baixos e, portanto, uma grande quantidade de água no estrato córneo [7] . A sensibilidade desta variável é maior quando se usam testes de provocação, incluindo o teste de oclusão plástica (POST) comumente usado [8][9][10] . Este estudo tem como objetivo avaliar o impacto do uso regular de quatro semanas de duração de um gel desinfetante à base de álcool na hidratação cutânea e na função epidérmica 'barreira' in vivo, usando um modelo cinético já estabelecido de curvas de dessorção de PTEA na sequência de um teste POST.…”

Section: Introductionunclassified

“…Healthy skin tends to possess lower TEWL values and therefore, a larger amount of water in the stratum corneum [7] . The sensitivity of this variable is increased when employing provocation tests, including the commonly used plastic occlusion stress test (POST) [8][9][10] . This study aims to evaluate the impact of a four week-long regular use of an alcohol-based gel hand sanitizer on in vivo skin hydration and the epidermal 'barrier' function, using a previously established kinetic modelling of TEWL desorption curves following a POST test.…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration

Silva

Tavares

Faria

et al. 2015

BBR

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Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2015; (12) 2: , 243-249 243 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aAssessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration AbstractThe Stratum corneum is a principal protector against physical, chemical, biological aggression and water loss in human skin. The repeated use of alcohol-based hand sanitizers might result in dryness and aggression. This study aims to evaluate the impact of a four week-long regular use of an alcohol-based gel hand sanitizer on skin hydration on the epidermal 'barrier' function using a kinetic model to quantify TEWL desorption curves following a POST test. A group of 13 female (19.7 ± 1.0 years old) washed one of their hands for 29 consecutive days with a commercially available ethanol-based gel sanitizer. TEWL, superficial hydration (SH) and deep hydration (DH) were measured on days 1, 8, 15, 22 and 29, while a continuous TEWL recording following a 24 hour POST was made on days 1, 15 and 29 on a second skin area. No differences were found for the control hand throughout the study. For the test hand an increase of TEWL was found between days 1 and 8, as well as an increase of SH and DH between days 1 and 22. No significant differences were found for the kinetic parameters. These results suggest that the frequent use of the sanitizer gel might alter the skin barrier function. Keywords: hand sanitizer, TEWL, epidermal hydration, dynamic assessment ResumoO estrato córneo é o principal protetor contra a agressão física, química, biológica e perda de água na pele humana. A lavagem repetida das mãos especialmente com desinfetantes à base de álcool pode resultar em secura e agressão. Este estudo tem como objetivo avaliar o impacto do uso regular de quatro semanas de duração de um gel desinfetante para as mãos à base de álcool sobre a hidratação da pele sobre a função de 'barreira' epidérmica usando um modelo cinético para quantificar as curvas de dessorção de PTEA na sequência de um teste POST. Um grupo de 13 mulheres (19,7 ± 1,0 anos de idade) lavaram as mãos durante 29 dias consecutivos com um desinfetante gel à base de etanol disponível no mercado. A PTEA, hidratação superficial (HS) e hidratação profunda (HP) foram medidas nos dias 1, 8, 15, 22 e 29, enquanto a PTEA foi registada continuamente na sequência de um POST de 24h nos dias 1, 15 e 29 numa segunda zona da pele . Não foram encontradas diferenças para a mão de controlo ao longo do estudo. Para a mão teste foi encontrado um aumento de PTEA entre os dias 1 e 8, bem como um aumento de SH e DH entre os dias 1 e 22. Nenhuma diferença significativa foi encontrada com os parâmetros cinéticos. Estes resultados sugerem que o uso frequente do gel desinfetante para as mãos pode alterar a função de barreira da pele.Palavras-chave: desinfetante de mãos, PTEA, hidratação epidérmica, avaliação dinâmica

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Is there any barrier impairment in sensitive skin?: a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves

Cited by 68 publications

References 30 publications

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy

Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration

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