Is there an increased risk of breast cancer in women who have had a breast cyst aspirated?

Abstract

Summary A consecutive series of 644 women who presented with breast nodularity between 1976

The enigmatic nature of apocrine breast lesions

“…Several reports have assessed the relation between palpable breast cysts and breast carcinoma and suggested that there is an increased risk of breast carcinoma, which ranges from 1.7 to 7.5 times [68,17,8,11,6]. Haagensen et al found a fivefold-increased incidence of carcinoma associated with papillary apocrine metaplasia in fibrocystic changes, although this fact has subsequently been questioned [12,35].…”

Intracystic epidermal growth factor level is predictive of breast-cancer risk in women with gross cystic disease of the breast

“…7 The clinical implications of an increased risk of breast cancer in women with GCD should be considered. Ciatto et al 10 concluded that the increased risk they observed did not justify per se increased surveillance of patients; however, Bundred et al 13 advised that women with breast cysts should be encouraged to undertake breast self-examination, and all investigators have agreed on the need to identify susceptibility to breast cancer among women with palpable cysts. 2,3 Although an association of cyst type with the number of births (but not with age at first birth) has been reported, 14 there is no evidence that reproductive history might help in dis- criminating further the risk of women with breast cysts.…”

Prostate specific antigen molecular forms in breast cyst fluid and serum of women with fibrocystic breast disease

“…Women with Type-I breast cysts (with high K + /Na + ratio) may have a higher risk of subsequent development of breast cancer (14,18,19). In recent studies, we reported that there are significant differences in the molecular forms of PSA in serum of women with or without breast diseases.…”