Is there an association between blood group O and epistaxis?

Reddy, Venkat M.; Daniel, Matija; Bright, Elizabeth; Broad, Samuel Robin; Moir, Andrew

doi:10.1017/s0022215107008560

Cited by 32 publications

(26 citation statements)

References 8 publications

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“…The logical extension of these associations to correlations with ABO blood type and thrombo-embolic phenomena has also been demonstrated [22]. ABO phenotype has also been shown to correlate with haemorrhagic pathologies, including cerebral haemorrhage [23] and epistaxis [24]. Prior to our series, ABO phenotype was not specifically associated with post-operative haemorrhage.…”

Section: Type-o Blood and Coagulationsupporting

confidence: 55%

ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage

Léonard

Fenton

Hone

2010

International Journal of Pediatric Otorhinolaryngology

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Section: Type-o Blood and Coagulationsupporting

confidence: 55%

ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage

Léonard

Fenton

Hone

2010

International Journal of Pediatric Otorhinolaryngology

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“…Reddy et al [1] found in their study that among Caucasian epistaxis patients 50.4 patients were blood group O but among control groups this was 45.10%.…”

Section: Discussionmentioning

confidence: 88%

“…Earlier it has been reported that blood group O was over represented in Caucasian patients admitted with epistaxis, compared with the Caucasian population in general [1] . One study revealed that bleeding time was significantly longer in people with blood group O than people with non-O blood group and this could not be correlated with sex ratio, platelet count or hematocrit [2] .…”

Section: Introductionmentioning

confidence: 95%

Comparison of Bleeding Time and Clotting Time in Different Blood Groups

Mahapatra¹

2009

American Journal of Infectious Diseases

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Problem statement:Researchers have demonstrated that epistaxis is more often encountered in patients having blood group O probably due to lower expression of von Willebrand factor. We had taken up this study to find out if there is any definite relationship between the blood groups with the bleeding time and clotting time in our population. Approach: This retrospective study was conducted in the department of physiology in our institution. The available detail reports of 740 students passing through 1st year of MBBS over the years from 1999-2007 were analyzed in respect of age, sex, blood groups, bleeding time and clotting time. The blood grouping was done with the standard antisera and bleeding time and clotting time were estimated by Duke method and capillary tube method respectively. Finally bleeding time and clotting time of different blood groups were compared and statistical analysis was done. Results: In present study population O group was found in more number of cases (37.8%) than A, B and AB. Clotting time was found to be prolonged more than 6 min in maximum number of cases in B group (12.7 cases) followed by A group (8) and O group (5.8) and AB group (4.3%). Similarly bleeding time was more than 4 min in AB group in 21.8 followed by 13.9 in group B, 10.5 in group A and 9.6% in group O. Conclusion: In present study population interestingly clotting time was more in blood group AB and bleeding time in blood group B than other blood groups which was statistically significant. Further study needed to correlate the association of this finding in cases of epistaxis and hemoptysis in our population.

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“…21 (Table S1), which has recently been found in the Vienna Bleeding Biobank (VBB) to be associated with the diagnosis of a bleeding disorder and previously been described in association with bleeding from a range of causes , . [22][23][24][25] TxA and desmopressin and rarely platelet transfusion were successful in more than 90% of cases at reducing bleeding complications when given as haemostastic prophylaxis preprocedure; 16 of 69 procedures were high bleeding risk and no abnormal bleeding was observed ( 11 The variability we describe in management with platelets, TXA and desmopressin reflects the uncertainty of managing UBD given the lack of any clinical trials. Many patients, prior to diagnosis, experienced postoperative, postdental or PPH; 75%, 84% and 63%, respectively, for patients exposed to each risk.…”

Section: Discussionmentioning

confidence: 94%

Characterization of a large cohort of patients with unclassified bleeding disorder; clinical features, management of haemostatic challenges and use of global haemostatic assessment with proposed recommendations for diagnosis and treatment

MacDonald

Wright

Beuche

et al. 2019

Int J Lab Hematology

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Introduction There is an unmet need to characterize the diagnosis and management of patients with an unclassified bleeding disorder (UBD). Methods Retrospective review of registered patients with UBD at our centre. Assessment including rotational thromboelastometry (ROTEM) and thrombin generation (TG) were used. Results A total of 124 patients were identified; 91% female. Mean age of presentation was 38.3 years. Mean bleeding score was 8.8 (standard deviation [SD] 3.8); 6.6 in men (SD 1.4) and 9.7 in women (SD 3.3), which was significantly different (P < .05). In women, after deduction of scores for menorrhagia and postpartum haemorrhage, the mean score was 6.4 which was not significantly different to the male score (P = .11). Twenty‐three percent of patients have been transfused, 61% women had treatment for menorrhagia and 17% for epistaxis. TxA and desmopressin were effective at preventing bleeding in 69 procedures and 13 deliveries. TG revealed 26% patients with a long lag time and 19% with a decreased endogenous thrombin potential but no diagnostic pattern was seen. ROTEM (NATEM) was unable to characterize patients; 9% had a prolonged clot time or maximum lysis. ThromboGenomics was normal in 45 tested patients. Conclusions We provide data which shows the bleeding score is biased towards gynaecological bleeding but which remains elevated even when the bleeding score is deducted. Tranexamic acid and desmopressin are effective as haemostatic prophylaxis but there is an urgent need for clinical trials. In conclusion, we describe the use of the bleeding score in these patients and phenotype, diagnosis (including ThromboGenomic testing) and management with practice recommendations.

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Is there an association between blood group O and epistaxis?

Abstract: Blood group O appears over-represented in Caucasian patients admitted with epistaxis, compared with the control population, raising the possibility that blood group O is a risk factor for epistaxis.

Cited by 32 publications

References 8 publications

ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage

ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage

Comparison of Bleeding Time and Clotting Time in Different Blood Groups

Characterization of a large cohort of patients with unclassified bleeding disorder; clinical features, management of haemostatic challenges and use of global haemostatic assessment with proposed recommendations for diagnosis and treatment

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