Is there an association between vitamin D deficiency and adenotonsillar hypertrophy in children with sleep-disordered breathing?

Shin, Ji-Hyeon; Kim, Byung-Guk; Kim, Soo Whan; Kim, Sung Won; Kim, Hojung

doi:10.1186/s12887-018-1178-8

Cited by 18 publications

(4 citation statements)

References 69 publications

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“…Recurrent infections associated with AH are due to impaired mucociliary clearance and decreased ciliary beat frequency, which is additionally reduced by tobacco smoke exposure (17,18) . The predisposing factors for adenoid hypertrophy include allergy, tobacco exposure, vitamin D deficiency and GERD, which were also found in children included in the present study (15,(19)(20)(21)(22) . The association between allergic diseases and recurrent respiratory tract infections is the subject of many publications (23) .…”

Section: Discussionsupporting

confidence: 63%

Multifactorial aetiology of recurrent respiratory tract infections in children

Kleszyk¹,

Mizgała-Izworska²,

Góra³

et al. 2021

Pediatr Med Rodz

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Recurrent respiratory tract infections in children are a common health problem. Exposure to harmful environmental agents and coexistence of chronic diseases affect the severity and rate of infections. Ineffective outpatient treatment is an indication for a more comprehensive diagnostic workup. The aim of the study was to determine the cause of recurrent respiratory tract infections in children. The study group included 130 children aged 3–17 years who were referred for diagnostic investigation to determine the cause of recurrent respiratory tract infections. The eligibility criterion for the study group was the occurrence of 8 or more respiratory tract infections a year in children aged up to 6 years and 5 or more infections a year in children aged 7–17 years. The study group was subdivided into the following age groups: 3–5 years (n = 60), 6–9 years (n = 35), 10–13 years (n = 11) and 14–17 years (n = 24). The presence of potential risk factors for recurrent infection was analysed on the basis of questionnaires. Tests and examinations were also performed in order to exclude allergies, ear, nose and throat disorders and gastroesophageal reflux disease. Selected laboratory values (complete blood count, vitamin D concentration, immunoglobulin levels) were compared with those obtained from 86 healthy children from the control group. The majority of children had risk factors for recurrent respiratory tract infections. Adenoid hypertrophy was diagnosed in 44.6% of children, asthma in 36.9%, vitamin D deficiency in 30.7%, gastroesophageal reflux disease in 16.2% and immunodeficiency in 9.2% of children. Multimorbidity was found in 34.6% of the subjects. In the study group, there were higher vitamin D levels [study group: 25.6 ng/mL (25th percentile = 17; 75th percentile = 33.3), control group: 22.84 ng/mL (25th percentile = 16.3; 75th percentile = 28.7); p < 0.044] and higher leukocyte levels [study group: 7.5 × 103/μL (25th percentile = 5.9; 75th percentile = 9.1), control group: 6.4 × 103/μL (25th percentile = 5.3; 75th percentile = 7.7); p < 0.02]. The results indicate that children with recurrent respiratory tract infections are a heterogeneous group of patients. The youngest children were the largest group (n = 60). In the majority of children, the onset of symptoms was associated with the beginning of nursery/preschool or school attendance. In 1 in 3 children, a combined presence of a few diseases was found which increase susceptibility to recurrent respiratory tract infections.

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Section: Discussionsupporting

confidence: 63%

Multifactorial aetiology of recurrent respiratory tract infections in children

Kleszyk¹,

Mizgała-Izworska²,

Góra³

et al. 2021

Pediatr Med Rodz

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“…Concerning tonsillar size, we reported a significant relationship between serum vitamin D levels and tonsil size where lower levels of vitamin D were observed in patients with tonsil sizes of grade III+IV compared to grade I+II. Other studies have reported that vitamin D levels were negatively associated with the sizes of tonsils [ 6 , 30 ]. This may be explained using a mouse model [ 31 ], that vitamin D receptor-deficient mice exhibit an accumulation of mature dendritic cells, leading to subcutaneous lymph nodes enlargement.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum 25(OH) Vitamin D as a Risk Factor in Adult Recurrent Tonsillitis

Hussein¹,

Alqannass²,

Mansour³

et al. 2022

Cureus

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BackgroundStudies have reported that the rate of upper respiratory tract infections in children and adults is inversely related to serum vitamin D levels and supplementation with vitamin D reduces the incidence of this infection. This study aimed to examine if vitamin D serum levels were a risk factor for recurrent tonsillitis among adult patients. MethodsRetrospective comparative analysis was carried out on 100 patients diagnosed with recurrent tonsillitis with 100 age-and sex-matched individuals as controls between June 2016 and May 2022. Tonsillar size was assessed based on Brodsky grading system. Serum levels of 25-hydroxy (25(OH)) vitamin D, total calcium, iron, hemoglobin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were analyzed. ResultsThere was a statistically significant low vitamin D levels in tonsil size grades III+IV compared to grade I+II (p <0.001) among cases. There was a significantly lower serum value for 25(OH) vitamin D in the cases as compared to the control group (p <0.001). A high percentage (68%) of cases had vitamin D deficiency (<20 ng/mL) and this was statistically significant (p <0.001). There were statistically significant higher values of CRP and ESR among cases compared to the control group (p <0.001). At a cut off (≤21.2), serum vitamin D levels achieved 78% sensitivity, 65% specificity (p <0.001) to differentiate cases from controls. Following logistic regression analysis, the level of vitamin D was the only significant risk factor. ConclusionFindings from our study also suggest an association between recurrent tonsillitis among our adult cohorts and low serum 25(OH) vitamin D levels. Therefore, we opine that serum vitamin D levels should be considered in the management of adult patients with tonsillitis.

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“…had note d the prevalence of 91.3% of children presenting with vitamin D deficiency in recurrent adenotonsillitis. 7 Reid et.al. had noted increased incidence of upper respiratory tract infection in patients with deficient serum vitamin D level (< 20 ng/mL).…”

Section: Archives Of the Medicine Andmentioning

confidence: 99%

The Association between Vitamin D Deficiency and Chronic Tonsillitis in Children: an Evidence Based Case Report

Pramesti

Putri

Sonia

2021

AMCR

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Background: vitamin D has an important influence on the host’s immune system by modulating both innate and adaptive immunity and regulating the inflammatory cascade. Vitamin D deficiency may be related with reduced immunomodulation, specifically in preventing the occurrence of chronic tonsillitis. Objective: to identify the association between vitamin D deficiency with chronic tonsillitis in pediatric patients. Methods: the search was conducted with advanced searching on PubMed® and Cochrane® according to the clinical question. The screening of title and abstract using inclusion and exclusion criteria, double filter, and reading full text led to six useful articles. The selected studies were critically appraised for validity, importance, and applicability. Results: three original articles were eligible for this evidence-based case report. All studies were considered to have good validity. All three studies reported an increased risk of chronic tonsillitis with the vitamin D deficiency and/or insufficiency. Conclusion: Vitamin D deficiency may be associated with the increased risk of chronic or recurrent tonsillitis in children.

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Is there an association between vitamin D deficiency and adenotonsillar hypertrophy in children with sleep-disordered breathing?

Cited by 18 publications

References 69 publications

Multifactorial aetiology of recurrent respiratory tract infections in children

Multifactorial aetiology of recurrent respiratory tract infections in children

Evaluation of Serum 25(OH) Vitamin D as a Risk Factor in Adult Recurrent Tonsillitis

The Association between Vitamin D Deficiency and Chronic Tonsillitis in Children: an Evidence Based Case Report

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