Is There an Association between β-Carotene and Breast Cancer? A Systematic Review on Breast Cancer Risk

Peraita-Costa, Isabel; García, Paula Carrillo; Morales-Suárez-Varela, María

doi:10.1080/01635581.2020.1865422

Cited by 10 publications

(8 citation statements)

References 68 publications

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“…In previous studies, women with higher levels of vitamin C, α-carotene, β-carotene, or cryptoxanthin appeared to have a lower risk of BC than women with low levels of these antioxidants, while retinol was positively correlated with BC risk in relation to ER2/progesterone receptor–negative tumors [ 38 ]. Another systematic review and meta-analysis provided limited evidence regarding pre-diagnosis dietary intake of β-carotene and the overall survival of women with BC [ 48 ], while a recent systematic review supported the role of β-carotene in BC prevention [ 49 ]. A recent study suggested that pre-diagnosis concentrations of vitamin E were moderately—strongly associated with ER-BC risk after analysis with a metabolomic approach [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Mediterranean Diet Affects Blood Circulating Lipid-Soluble Micronutrients and Inflammatory Biomarkers in a Cohort of Breast Cancer Survivors: Results from the SETA Study

et al. 2021

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Breast cancer (BC) is a major public health concern and substantial research has shown that adhering to a healthy dietary pattern, such as the Mediterranean Diet (MD), may prevent the onset of cancer and BC relapses. This study aims at specifically investigating the association of MD with circulating dietary-related biomarkers in a cohort of BC survivors. Eighty patients (mean age of 54.9 ± 10.6) with a histologically confirmed diagnosis of BC who had not received any pharmacological or radiotherapy treatment for at least two months were enrolled. Fasting serum lipid-soluble vitamins (retinol, tocopherol), plant pigments (β-carotene, lutein + zeaxanthin, cryptoxanthin, lycopene), inflammatory and oxidative stress markers (ceruloplasmin; haptoglobin; paraoxonases; reactive oxygen molecule; thiol groups, Ferric reducing antioxidant power), and cardiometabolic parameters (body mass index (BMI); glucose; insulin; HOMA-IR; total cholesterol; LDL-cholesterol; HDL-cholesterol; triglycerides) were analyzed. Adherence to the MD was assessed through the Mediterranean Diet Score (MDS) questionnaire. Fasting blood samples were collected for the evaluation of selected biomarkers. MDS resulted positively correlated with β-carotene (r 0.331; p < 0.01) and lycopene (r 0.274; p < 0.05) and negatively with retinol (r −0.346; p < 0.05). Among the investigated inflammatory biomarkers, MDS was only correlated with antioxidant capacity (r 0.256; p < 0.05), while none of the investigated cardiometabolic parameters were significantly correlated with this index. The strong significant correlation between β-carotene and MDS encourages us to consider this pro-vitamin as a putative biomarker to take into account for evaluating the adherence to the MD.

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Section: Discussionmentioning

confidence: 99%

Mediterranean Diet Affects Blood Circulating Lipid-Soluble Micronutrients and Inflammatory Biomarkers in a Cohort of Breast Cancer Survivors: Results from the SETA Study

et al. 2021

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“…Over 95% of the total carotenoids in human blood are composed of six carotenes, namely, α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin [105]. Peraita-Costa et al [106] conducted a review of 28 epidemiological studies to summarize the association between breast cancer and carotenoids. The authors observed an inverse association between carotenoid intake, particularly β-carotene, and the risk of breast cancer.…”

Section: Carotenoidsmentioning

confidence: 99%

The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns

Tsai

Hsu

et al. 2023

Nutrients

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Breast cancer is a significant public health problem globally and prevention strategies have become of great interest as its incidence rises. Exploring the connection between dietary patterns and the reduction of breast cancer risk is considered a promising approach. High levels of fiber, phytochemicals, a good antioxidant profile, and a composition of advantageous fatty acids are characteristics of healthy dietary programs such as the Mediterranean diet. This review summarized and discussed the active compounds that are considered important in preventing breast cancer, including dietary components from recent related reports. These include polyunsaturated fatty acids, fiber, phytochemicals, and alcohol. Although the exact mechanism for preventing breast cancer using these dietary factors is not well understood, the combination of all the elements in a healthy diet plays a role in reducing breast cancer risk. Considering the elevated probability of breast cancer relapse and mortality, it is crucial to investigate the correlation between a nutritious dietary pattern and breast cancer, while identifying bioactive components that have the potential to mitigate the risk of breast cancer incidence.

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“…In the recent COST ACTION CA15136 “EUROCAROTEN,” researchers have been exploring different topics related to carotenoids that could lead to new technologies and/or high-quality foods. Overall, they aim to increase the knowledge, research, and competitiveness of the European agro-food industry [ 12 , 13 , 14 , 15 , 16 ]. An additional important goal the EUROCAROTEN network is trying to promote is the enhancement of knowledge on the health-related effects of these compounds by collecting data and coordinating studies that will reveal the mechanisms of health impacts [ 17 ], provide evidence on health biomarkers [ 18 ], and indicate health-promoting nutritional recommendations [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

What Is the Current Direction of the Research on Carotenoids and Human Health? An Overview of Registered Clinical Trials

et al. 2022

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Carotenoids have been the object of numerous observational, pre-clinical and interventional studies focused on elucidating their potential impacts on human health. However, the large heterogeneity among the trials, in terms of study duration and characteristics of participants, makes any conclusion difficult to draw. The present study aimed to explore the current carotenoid research trends by analyzing the characteristics of the registered clinical trials. A total of 193 registered trials on ClinicalTrials.gov and ISRCTN were included in the revision. Eighty-three studies were performed with foods, one-hundred-five with food supplements, and five with both. Among the foods tested, tomatoes and tomato-based foods, and eggs were the most studied. Lutein, lycopene, and astaxanthin were the most carotenoids investigated. Regarding the goals, 52 trials were focused on studying carotenoids’ bioavailability, and 140 studies investigated the effects of carotenoids on human health. The main topics included eye and cardiovascular health. Recently, the research has focused also on two new topics: cognitive function and carotenoid–gut microbiota interactions. However, the current research on carotenoids is still mostly focused on the bioavailability and metabolism of carotenoids from foods and food supplements. Within this context, the impacts/contributions of food technologies and the development of new carotenoid formulations are discussed. In addition, the research is still corroborating the previous findings on vision and cardiovascular health. Much attention has also been devoted to new research areas, such as the carotenoid–microbiota interactions, which could contribute to explaining the metabolism and the health effects of carotenoids; and the relation between carotenoids and cognitive function. However, for these topics the research is still only beginning, and further studies are need.

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Is There an Association between β-Carotene and Breast Cancer? A Systematic Review on Breast Cancer Risk

Cited by 10 publications

References 68 publications

Mediterranean Diet Affects Blood Circulating Lipid-Soluble Micronutrients and Inflammatory Biomarkers in a Cohort of Breast Cancer Survivors: Results from the SETA Study

Mediterranean Diet Affects Blood Circulating Lipid-Soluble Micronutrients and Inflammatory Biomarkers in a Cohort of Breast Cancer Survivors: Results from the SETA Study

The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns

What Is the Current Direction of the Research on Carotenoids and Human Health? An Overview of Registered Clinical Trials

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