Is there an association between wheezing and constipation in preschool children? Explanations from a longitudinal birth cohort

Jong, Jessica C. Kiefte-de; Lebon, Ankie; Jaddoe, Vincent W.V.; Hofman, Albert; Jongste, Johan C. de; Moll, Henriëtte A.

doi:10.1136/bmjopen-2011-000237

Cited by 4 publications

(7 citation statements)

References 51 publications

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“…Finally, 3 articles ful lled our eligibility criteria and were included in this meta-analysis (Fig. 1) [11,13,15] . All selected studies were cohort studies and assessed by NOS and their score of them ranged from 6 to 8, suggesting that the methodological quality was acceptable.…”

Section: Studies Selected and Their Characteristicsmentioning

confidence: 99%

“…Yen-Chu Huang [11] 2021 China (Taiwan) J C Kieftede Jong [15] 2011 Netherlands 4651 a longitudinal birth cohort newborns wheezing OR 1.10 (0.96-1.25) 7…”

Section: Nosmentioning

confidence: 99%

“…An altered contractility and smooth muscle tone have been observed in both diseases [12][13][14] . However, other researchers think that wheezing symptoms are not associated with constipation after adjusting for the child's exposure to infections and use of antibiotics [15] .…”

Section: Introductionmentioning

confidence: 97%

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Association Between Constipation and the Development of Asthma: A Meta-Analysis

Liu¹,

Zhang²,

Jiang

et al. 2022

Preprint

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Background Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipation influence the risk of wheezing/asthma. Methods PubMed, Embase, and Web of Science were systematically searched for studies published between 1955 and January 2022. Two reviewers independently extracted data and assessed the quality of each study. Results were pooled using fixed-effect models or random-effects models as appropriate. Results In total, 3 original articles with 178762 participants which met the criteria were included in this meta-analysis. Constipation was associated with an increased risk of wheezing/asthma in later life (RR = 2.14, 95% CI = 1.30 to 3.54, P < 0.01). Conclusions The meta-analysis suggests an association between constipation and the subsequent development of wheezing/asthma. Well-designed and highly standardized prospective studies that adequately address concerns for potential confounding factors are required to validate the risk identified in our current meta-analysis.

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Section: Studies Selected and Their Characteristicsmentioning

confidence: 99%

“…Yen-Chu Huang [11] 2021 China (Taiwan) J C Kieftede Jong [15] 2011 Netherlands 4651 a longitudinal birth cohort newborns wheezing OR 1.10 (0.96-1.25) 7…”

Section: Nosmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Constipation and the Development of Asthma: A Meta-Analysis

Liu¹,

Zhang²,

Jiang

et al. 2022

Preprint

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“…An altered contractility and smooth muscle tone have been observed in both diseases [ 15 – 17 ]. However, other researchers think that wheezing symptoms are not associated with constipation after adjusting for the child’s exposure to infections and use of antibiotics [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Association between constipation and the development of asthma: a meta-analysis

Liu

Zhang

Jiang

et al. 2022

Allergy Asthma Clin Immunol

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Background Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipation influences the risk of wheezing/asthma. Methods PubMed, Embase, and Web of Science were systematically searched for studies published between 1955 and January 2022. Two reviewers independently extracted data and assessed the quality of each study. Results were pooled using fixed-effects models or random-effects models as appropriate. Results In total, 3 original articles with 178,661 participants, which met the criteria, were included in this meta-analysis. Constipation was associated with an increased risk of wheezing/asthma in later life (RR = 2.02, 95% CI = 1.24–3.29, P < 0.01). Conclusions The meta-analysis suggests an association between constipation and the subsequent development of wheezing/asthma. Well-designed and highly standardized prospective studies that adequately address concerns for potential confounding factors are required to validate the risk identified in our current meta-analysis.

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“…Recently, Leander et al (25) showed that constipation was associated with asthma and wheezing symptoms in preschool children. In a longitudinal birth cohort study, Kiefte-de Jong et al (26) found that wheezing symptoms and FC frequently coexist in preschool children. No significant association was identified between the symptoms of atopic dermatitis and FC.…”

Section: The Association Of Atopic Diseases With Ibs or Fcmentioning

confidence: 99%

Allergy in Children with Functional Constipation and Irritable Bowel Syndrome

et al. 2016

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Context: Functional constipation (FC) and irritable bowel syndrome (IBS) represent very common pediatric functional gastrointestinal disorders (FGIDs). Controversial results have suggested a potential role of food allergy as a trigger of functional bowel symptoms. Evidence Acquisition: This review summarizes the literature regarding the role of allergic diseases in children with FC and IBS and discusses the hypothesis of the pathogenesis of constipation due to cow's milk protein allergy (CMPA). We searched systematic reviews, guidelines, or original data in PubMed, MEDLINE, and the Cochrane central register of controlled trials. Results: The pathogenesis of FGIDs remains elusive and is likely multifactorial. Among these factors, adverse reactions to food may play a pathogenic role. Some features, such as abnormal bowel motility, visceral hypersensitivity, and changes in mucus composition caused by inflammation of the gastrointestinal wall, have been found both in IBS or FC and in food allergy. Since 1978, an increasing number of reports have suggested a relationship between CMPA and FC. Two randomized controlled studies conducted in children showed that CMPA may induce chronic FC; one study indicated that fermentable oligosaccharide, disaccharide, and monosaccharide polyols (FODMAP) foods may play a role in triggering IBS. Conclusions: Food allergy in children with chronic constipation should be identified using an oral food challenge after being on a diet free of cow's milk. A diet low in FODMAPs might also be recommended for children with IBS. This approach could be suggested for children with chronic FC and IBS, especially when they do not respond to standard treatment. However, it should also be considered that a minority of patients with FC or IBS could respond to an elimination diet. Further studies are needed to understand the complex pathogenic mechanisms of FGIDs; they also might be helpful to recognize markers for identifying children with IBS and FC caused by foods and to improve their management.

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Is there an association between wheezing and constipation in preschool children? Explanations from a longitudinal birth cohort

Cited by 4 publications

References 51 publications

Association Between Constipation and the Development of Asthma: A Meta-Analysis

Association Between Constipation and the Development of Asthma: A Meta-Analysis

Association between constipation and the development of asthma: a meta-analysis

Allergy in Children with Functional Constipation and Irritable Bowel Syndrome

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