Association between constipation and the development of asthma: a meta-analysis

Abstract

Background Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipation influences the risk of wheezing/asthma. Methods PubMed, Embase, and Web of Science were systematically searched for studies published between 1955 and January 2022. Two reviewers independently extracted data and assessed the quality of each study. Results were pooled using fixed-effects models or random-effects models as appropriate. Results In total, 3 original articles with 178,661 participants, which met the criteria, were included in this meta-analysis. Constipation was associated with an increased risk of wheezing/asthma in later life (RR = 2.02, 95% CI = 1.24–3.29, P < 0.01). Conclusions The meta-analysis suggests an association between constipation and the subsequent development of wheezing/asthma. Well-designed and highly standardized prospective studies that adequately address concerns for potential confounding factors are required to validate the risk identified in our current meta-analysis.

Bioactive peptides as alternative treatment for Helicobacter pylori infection

“…Furthermore, the pathogen dynamics with the microbiota of the gastrointestinal tract is highly complex, and eradication not only affects the gastrointestinal tract itself, but also its absence has been associated with dysbiosis and the emergence of a variety of systemic disorders, weight gain or loss, and susceptibility to allergic diseases such as asthma [43,[74][75][76][77][78][79]. In contrast, research over the years has demonstrated that eradicating H. pylori prior to the onset of precancerous histological changes can prevent the development of gastric cancer and dysbiosis can be managed with the integration to the antibiotic treatment of probiotics and other alternatives for microbiota modulation [80][81][82].…”