Is There a Stein--Leventhal Syndrome?

Roberts, Diane; Haines, Magnus

doi:10.1136/bmj.1.5187.1709

Cited by 22 publications

(4 citation statements)

References 8 publications

(4 reference statements)

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“…Many different sized follicles in all stages of maturation and atresia are found with a normal or variably increased layer of luteinized perifollicular theca interna cells often associated with stromal cell hyperplasia as well as theca cell hyperplasia in the ovarian stroma (8,(12)(13)(14)(15)(16)(17). The latter is usually associated with more severe masculinizing features, diabetes mellitus, and hypertension (hyperthecosis) (17).…”

Section: Discussionmentioning

confidence: 98%

“…The latter is usually associated with more severe masculinizing features, diabetes mellitus, and hypertension (hyperthecosis) (17). Fibrosis and hyperplasia of stroma have been reported as absent (13) or occasionally present (18)(19)(20). In the study of Hughesdon (8) of full length ovarian wedges of 17 patients with Stein-Leventhal syndrome and 18 control subjects, a marked increase in the subcortical or medullary stroma was found compared to normal ovaries, while 80% of Stein-Leventhal patients had foci of stromal luteinization not present in normal ovaries.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological Effects of Exogenously Administered Testosterone in 19 Female to Male Transsexuals

Futterweit

Deligdisch

1986

The Journal of Clinical Endocrinology & Metabolism

176

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The effects of exogenously administered testosterone were evaluated in a group of 19 female to male transsexuals who underwent bilateral salpingo-oophorectomy after a variable period of androgen therapy. The findings were compared to those in an age-matched group of 12 patients who underwent pelvic surgery for nonendocrine reasons. The most significant findings in the 19 androgen-treated female transsexuals was the finding of enlarged or borderline enlarged ovaries in 5 subjects. In addition, we found multiple cystic follicles in 17 patients (89.5%), diffuse ovarian stromal hyperplasia in 16 patients (84.2%), collagenization of the outer cortex in 13 patients, and 4) luteinization of stromal cells in 5 patients (26.3%). Findings consistent with polycystic ovaries were thus present in 13 of the 19 patients based on the presence of 3 of the above 4 findings. The data suggest that increased blood levels and presumably increased ovarian concentrations of testosterone may produce the morphological features of polycystic ovarian disease.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Histopathological Effects of Exogenously Administered Testosterone in 19 Female to Male Transsexuals

Futterweit

Deligdisch

1986

The Journal of Clinical Endocrinology & Metabolism

176

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“…Apart from the fact that enlarged ovaries may frequently not be palpable, numerous cases of polycystic ovarian disease with normal sized ovaries (4,7,15) or even unilateral enlargement (4,11,13) have been reported. Evidently, these normal sized polycystic ovaries represent the same disturbance, for their clinical presentations and response to wedge resection are known to be comparable (2,8,12 little information available in this series, especially, the urinary steroids (17 ketosteroids and 17 hydroxycorticosteroids). Since the common endocrinological denominator in these disorders is the presence of excessive circulating androgens and a disturbance of the pituitaryadrenal mechanism which might well disturb the pituitary-ovarian axis, knowledge of the urinary steroid excretion would have been valuable.…”

Section: Discussionmentioning

confidence: 94%

“…Although the original description by Stein and Leventhal included enlarged ovaries, there have been a number of reviews over the past few years, describing similar clinical and histological patterns in normal-sized polycystic ovaries, and with similar dramatic response to wedge resection (2,8,12). Moreover, various reports of satisfactory results from wedge resection of these polycystic ovaries have aroused great interest especially as being a functional disorder curable by surgery.…”

Section: Introductionmentioning

confidence: 99%

Polycystic Ovaries

Adelusi¹,

Ve²,

Ea³

1976

International Journal of Gynecology & Obstetrics

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Polycystic ovarian disease has been recognised for quite a long time, although its presentations have varied from place to place. In a report of cases of polycystic ovaries seen in the University College Hospital, Ibadan, Nigeria, over a six-year period, it was shown that the syndrome of Stein-Leventhal identifies only a very small and probably artificial fraction of the much larger number of patients who actually have polycystic ovarian disease. It was further shown that the benefit derived from wedge resection in our cases was marked. Of the cases that were subsequently seen at follow-up, there was restoration of regular ovulatory menstrual flow in 83.3% and achievement of pregnancy in 33.3%. Hence, the observation that wedge resection is beneficial, and at times curative in polycystic ovarian disease seems to have a sound foundation.

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