Is there a role for Crohnʼs disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

Wolfkamp, Simone C.; Velde, Anje A. te; Weersma, Rinse K.; Ponsioen, Cyriel Y.; Stokkers, Pieter

doi:10.1097/meg.0b013e32833775e6

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…In around 50% of CD patients’ granulomas can be detected ( 74 ). Granulomas are linked to mycobacterium, and Mincle has been shown to be important ( 75 ).…”

Section: Mincle and CDmentioning

confidence: 99%

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Velde

2017

Front. Immunol.

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“…In around 50% of CD patients’ granulomas can be detected ( 74 ). Granulomas are linked to mycobacterium, and Mincle has been shown to be important ( 75 ).…”

Section: Mincle and CDmentioning

confidence: 99%

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Velde

2017

Front. Immunol.

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“…Therefore, it was hypothesized that single nucleotide polymorphisms (SNPs) in the IRGM gene may be important in the development of CD (15,16). Certain studies have indicated that a common polymorphism, rs13361189 C>T, in the IRGM gene may increase the risk of CD (17,18); however, individually published studies provided inconclusive results (19,20). Therefore, in the present study a meta-analysis of all eligible case-control studies was conducted to evaluate the correlation between the IRGM rs13361189 polymorphism and susceptibility to CD.…”

Section: Introductionmentioning

confidence: 99%

IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn’s disease: A meta-analysis

Lin

et al. 2014

Experimental and Therapeutic Medicine

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The aim of the present meta-analysis was to evaluate the correlation between a common polymorphism, rs13361189 C>T in the immunity-related GTPase M (IRGM) gene, and susceptibility to Crohn’s disease (CD). The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library and CBM databases were investigated from database inception through to October 1, 2013 without the application of any language restrictions. The meta-analysis was performed using STATA 12.0 software and the relative risk (RR) with a 95% confidence interval (CI) was calculated. Seven case-control studies were included with a total of 3,093 CD patients and 3,227 healthy control subjects. The results of the meta-analysis revealed that the IRGM rs13361189 polymorphism correlates with an increased risk of CD (T allele versus C allele: RR=1.25 with 95% CI, 1.04–1.50; P=0.016 and CT + TT versus CC: RR=1.21 with 95% CI, 1.03–1.42; P=0.018). A subgroup analysis conducted using a genotyping method indicated that the IRGM rs13361189 polymorphism was correlated with an increased risk of CD in the TaqMan® (T allele versus C allele: RR=1.32 with 95% CI, 1.01–1.73; P=0.042) and the polymerase chain reaction-restriction fragment length polymorphism subgroups (T allele versus C allele: RR=1.80 with 95% CI, 1.32–2.45; P<0.001 and CT + TT versus CC: RR=1.61 with 95% CI, 1.19–2.18; P=0.018). However, no correlation was observed in the direct sequencing subgroup (P>0.05). Further subgroup analysis by sample size demonstrated significant correlations between the IRGM rs13361189 polymorphism and an increased risk of CD in the large sample-size subgroup (T allele versus C allele: RR=1.46 with 95% CI, 1.26–1.68; P<0.001 and CT + TT versus CC: RR=1.40 with 95% CI, 1.21–1.62; P<0.001). However, no correlation was identified between the IRGM rs13361189 polymorphism and CD risk in the small sample-size subgroup (P>0.05). The present meta-analysis indicated that the IRGM rs13361189 polymorphism may contribute to susceptibility to CD. Thus, IRGM rs13361189 polymorphism may be a potential biomarker for the early diagnosis of CD.

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“…Among these SNPs in the IRGM gene, rs13361189 (C>T), rs10065172 (C>T), and rs4958847 (A>G) are the most common (Latiano et al, 2009;Brest et al, 2011;Gardet and Xavier, 2012). Large quantities of evidence have indicated that IRGM genetic polymorphisms increase the risk of CD (Roberts et al, 2008;Wolfkamp et al, 2010), but the results of these studies have been contradictory (Meggyesi et al, 2010;Zheng and Pang, 2012). Therefore, we performed this meta-analysis to evaluate the relationships between IRGM genetic polymorphisms and CD risk.…”

Section: Introductionmentioning

confidence: 99%

“…The titles and abstracts of all articles were reviewed and 53 were excluded; full texts and data integrity were then reviewed and another 51 papers were excluded. A total of 11 case-control studies were included in this meta-analysis (Roberts et al, 2008;Amre et al, 2009;Dema et al, 2009;Latiano et al, 2009;Meggyesi et al, 2010;Wolfkamp et al, 2010;Prager et al, 2012;Wang et al, 2012;Zheng and Pang, 2012;Durães et al, 2013;Moon et al, 2013). Publication years of the eligible studies ranged from 2008-2013.…”

Section: Characteristics Of the Studies Includedmentioning

confidence: 99%

Correlation between IRGM genetic polymorphisms and Crohn’s disease risk: a meta-analysis of case-control studies

Yao

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn's disease (CD). Eleven case-control studies were included, for a total of 5183 CD patients and 5571 healthy controls. Three common SNPs (rs13361189 C>T, rs10065172 C>T, and rs4958847 A>G) in the IRGM gene were assessed. We found that the IRGM rs13361189 polymorphism was significantly associated with an increased risk of CD [C allele vs T allele: odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.05-1.61, P = 0.017; CC + CT vs TT: OR = 1.32, 95%CI = 1.06-1.64, P = 0.013]. However, we observed no correlation between the rs10065172 and rs4958847 polymorphisms in the IRGM gene with susceptibility to CD (all P > 0.05). Subgroup analysis by ethnicity revealed significant associations between IRGM genetic polymorphisms and an increased risk of CD among Caucasian populations (C allele vs T allele: OR = 1.22, 95%CI = 1.07-1.40, P = 0.004; CC + CT vs TT: OR = 1.22, 95%CI = 1.05-1.41, P = 0.009), but not among Asian populations (all P > 0.05). Meta-regression analysis also confirmed that ethnic differences may be an important source of heterogeneity (P = 0.003). Our meta-analysis results indicate that the IRGM rs13361189 polymorphism contributes to the susceptibility to CD. Thus, the IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of CD. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of CD risk.

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Is there a role for Crohnʼs disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

Abstract: Our Crohn's disease patient cohort showed no association of the variants in ATG16L1 or IRGM and the presence of granulomas.

Cited by 6 publications

References 17 publications

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn’s disease: A meta-analysis

Correlation between IRGM genetic polymorphisms and Crohn’s disease risk: a meta-analysis of case-control studies

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