The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Velde, Anje A. te

doi:10.3389/fimmu.2017.01304

Cited by 12 publications

(13 citation statements)

References 90 publications

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“…The results from our study, taken together with those from the studies above, suggest that the pathogenic release of SAP130 might result in SAP130 acting as a proinflammatory DAMP in nonpathogen‐mediated inflammation. This corroborates te Velde's earlier suggestion that MINCLE ligands might function as proinflammatory DAMPs in CD . In fact, Mincle has been shown to regulate numerous inflammatory responses by binding with different ligands, such as bacteria, fungi, and some other molecules.…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, the surprising overlap in the immune reaction induced by related ligands and signaling molecules between CD and Mincle indicate that Mincle might have an important role in the pathogenesis of CD. 22,23 Admittedly, more detailed future studies are needed to confirm this.…”

Section: Discussionmentioning

confidence: 97%

“…Interestingly, many of the inflammatory reactions involving such bacteria, fungi, or other signaling molecules have been described to play a role in CD. Therefore, the surprising overlap in the immune reaction induced by related ligands and signaling molecules between CD and Mincle indicate that Mincle might have an important role in the pathogenesis of CD . Admittedly, more detailed future studies are needed to confirm this.…”

Section: Discussionmentioning

confidence: 99%

“…This corroborates te Velde's earlier suggestion that MINCLE ligands might function as proinflammatory DAMPs in CD. 22 In fact, Mincle has been shown to regulate numerous inflammatory responses by binding with different ligands, such as bacteria, fungi, and some other molecules. Interestingly, many of the inflammatory reactions involving such bacteria, fungi, or other signaling molecules have been described to play a role in CD.…”

Section: Discussionmentioning

confidence: 99%

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Preliminary exploration of the potential of spliceosome‐associated protein 130 for predicting disease severity in Crohn's disease

Gong

Zheng

et al. 2019

Annals of the New York Academy of Sciences

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The role of spliceosome‐associated protein 130 (SAP130) in gut inflammation, particularly in Crohn's disease (CD), remains unclear. The aim of our study was to analyze correlations between serum SAP130 levels and CD severity, and to assess its predictive value for the clinical efficacy of exclusive enteral nutrition (EEN) in CD. Correlations between the SAP130 levels and CD severity were evaluated. SAP130 and its receptor Mincle (macrophage‐inducible C‐type lectin) in the colon tissue in active CD were measured. Furthermore, the serum SAP130 level was investigated as a predictor of clinical efficacy in patients treated with EEN. The serum SAP130 levels significantly increased in patients with active CD compared with patients in remission for CD (P < 0.001) and control individuals (P < 0.001), and they varied according to clinical activity and significantly correlated with disease severity. In parallel, the expression of both SAP130 and Mincle in colon tissue was elevated in active CD. Additionally, the serum SAP130 level declined in patients with active CD who achieved efficacy at week 8 after EEN therapy. This preliminary evidence shows that SAP130 might be a potential noninvasive biomarker that correlates well with CD severity and the clinical efficacy of EEN in CD.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Preliminary exploration of the potential of spliceosome‐associated protein 130 for predicting disease severity in Crohn's disease

Gong

Zheng

et al. 2019

Annals of the New York Academy of Sciences

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“…Likewise, up-regulation of CHI3L1 and CLEC4E as observed in this study, was reported previously in IBD patients and may play a role in facilitating entry of adherent invasive Escherichia coli. 24,25 Thus, our choice of examined transcripts reflects a biologically relevant list of genes in the pathogenesis of IBD and links back to local and generalized dysbiosis in IBD patients.…”

Section: Immune Gene Expression In Cd11bþ Cells Relates To the Inflammentioning

confidence: 99%