Is There a Role for the Platelet-To-Lymphocyte Ratio in Chronic Lymphocytic Leukemia?

Bakouny, Ziad; Rassy, Elie El; Yared, Fares; Lutfallah, Antoine Abi; Ghosn, Marwan; Farhat, Fadi; Kattan, Joseph

doi:10.4155/fsoa-2018-0061

Cited by 4 publications

(3 citation statements)

References 18 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, Ahmed et al in a study reported that there was not significant associated between CBC results and advanced Rai stage [26]. Although Bakouny et al did not find significant relation between PLR with the survival of CLL patients [27], there was an inverse correlation between PLR and advanced clinical stages of CLL in our study. Considering the overall findings, we can hypothesis that PLR can act as a prognostic biomarker in CLL patients which requires further investigation.…”

Section: Discussioncontrasting

confidence: 77%

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

et al. 2020

View full text Add to dashboard Cite

Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters. Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p < 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, inverse association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, group 3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has an inverse correlation with neutrophil/lymphocyte ratio (r = −0.340, p = 0.046). Given that there is an inverse association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.

show abstract

Section: Discussioncontrasting

confidence: 77%

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, Sall et al study reported that lymphocyte count was signi cantly greater in patients with stage C than groups with stages A or B(24). Furthermore, Ahmed et al in a study reported that there was not signi cant associated between CBC results and advanced Rai stage(25).Although Bakouny et al did not nd signi cant relation between PLR with the survival of CLL patients(26), there was a negative association between PLR and advanced clinical stages of CLL in our study. Taken together, we can hypothesis that PLR can act as a prognostic biomarker in CLL patients which requires further investigation.…”

contrasting

confidence: 70%

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Bagheri

Vosoughi

Hosseinzadeh

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers expression with complete blood cell count (CBC) values and clinical parameters. Results: Peripheral blood samples were collected from 35 new CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, negative association with Rai staging, modified Rai staging, Binet staging systems (all p< 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, negative association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, as group3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has a negative correlation with neutrophil/lymphocyte ratio (r = -0.340, p = 0.046). Given that there is a negative association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.

show abstract

“…Regarding hematological diseases, data are rare: No data were available regarding NLR or MLR and different types of newly diagnosed acute leukemia or allogeneic stem cell transplantation. One study reported that PLR did not predict outcome in patients with chronic lymphatic leukemia 22 . In patients with diffuse large B-cell lymphoma, elevated PLR 23 and elevated NLR 24 were associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Pre-transplant platelet-to- lymphocyte ratio predicts outcome after allogeneic hematopoietic stem cell transplantation

Woelfinger

Hauptrock

Kriege

et al. 2022

Sci Rep

View full text Add to dashboard Cite

For many patients with hematological malignancies such as acute leukemia or myelodysplastic syndrome allogeneic hematopoietic stem cell transplantation (allogeneic HSCT) is the only curative treatment option. Despite the curative potential of this treatment many patients experience relapse of their underlying disease or die due to multiple complications e.g. infections. Risk scores could help to assess the individual prognosis and guide patients and treating physicians to choose between different treatment options. Parameters reflecting the inflammatory status, such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), have been demonstrated to be associated with prognosis and treatment complications in patients with various cancers. In this study, we evaluate pre-HSCT NLR, MLR and PLR as predictive markers in patients undergoing allogeneic HSCT. We demonstrate that a high (> 133) PLR level is associated with better clinical outcome. Patients with high pre-HSCT PLR show a significant better overall survival (p = 0.001), less relapses (p = 0.016), lower non-relapse-mortality (p = 0.022), less transfusions of red blood cells, platelets and fresh frozen plasma (p = 0.000), fewer episodes of fever (p = 0.002), considerably less different antibiotics (p = 0.005), fewer intensive care unit treatment (p = 0.017) and a lower in-hospital mortality (p = 0.024). Pre-HSCT PLR is easy to calculate by daily routine and could help to predict patient outcome after allogeneic HSCT.

show abstract

Is There a Role for the Platelet-To-Lymphocyte Ratio in Chronic Lymphocytic Leukemia?

Cited by 4 publications

References 18 publications

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Pre-transplant platelet-to- lymphocyte ratio predicts outcome after allogeneic hematopoietic stem cell transplantation

Contact Info

Product

Resources

About