Is There a Relationship between Serum D-Dimer Levels and Thorax CT Severity Score in Patients with COVID-19?: A Retrospective Analysis

Cevik, Belma; Akın, Kayıhan

doi:10.23937/2572-3235.1510089

Cited by 1 publication

(1 citation statement)

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“…D-dimers are small protein fragments that are released into the blood when a blood clot is degraded through fibrinolysis. Cases including deep vein thrombosis (DVT), pulmonary embolism, arterial thrombosis, disseminated intravascular coagulation, and conditions such as pregnancy, inflammation, cancer, chronic liver disease, post-traumatic, surgical status, and vasculitis can lead to an increase in D-dimer plasma levels ( 33 ). In this study, the D-dimer was significantly higher in the non-survived group than in the survived, and a correlation was found with mortality.…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Parameters at Admission as Predictors for Mortality in Patients with Moderate to Severe COVID-19

Pertiwi¹,

Nisa'²,

Aulia³

et al. 2023

Ethiop J Health Sci

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BACKGROUND: Timely diagnosis and effective use of available resources are urgent to avoid the loss of time, medical, and technological resources, particularly in COVID-19 pandemic. This study aimed to identify the most dominant predicting factor for mortality in moderate-severe COVID-19 patients.METHODS: This retrospective cohort study included a total of 253 patients diagnosed with moderate-severe COVID-19. The primary outcome measure was mortality during hospitalization. The receiver operating characteristic (ROC) curve was used to determine cut-off points. The data were categorized according to the cut-off points in ROC curve and analyzed using Chi-square and by binary logistic regression test to identify the independent predictors associated with mortality.RESULTS: The mean number of leukocytes (/μL), neutrophils (%), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP, mg/L), and D-dimer (mg/L) in the nonsurvived group was significantly higher than those of the survived group. Meanwhile, the mean number of platelet count/μL, absolute lymphocyte count (ALC), in the non-survived group was significantly lower than those of the survived group. CRP level predicted mortality with a cut-off point of ≥8.41 mg/L, sensitivity of 98.1%, and specificity of 72.0% (P = .000).CONCLUSIONS: High leukocyte count, low platelet count, high NLR, high CRP level, and high D-dimer on admission predicted mortality of COVID-19 patients. In addition, CRP was found to be the most dominant predicting factor of mortality in moderate-severe COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%