Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Alcohol Consumption and Avoidance

“…The pooled estimates for both the effect of alcohol consumption and dependence on the prevalence of neuropathy/NP indicate a protective effect, whereby alcohol use is associated with 50%, and 40% lower prevalence of neuropathy compared to non-use, respectively [ 39 , 42 , 43 , 46 , 48 , 51 , 57 , 58 , 59 , 67 , 70 , 73 , 80 , 84 , 85 ]. This directly contradicts the majority of studies (28/47, 60%) reporting greater prevalence of PN, diabetic PN, chemotherapy-induced PN, PoN, and NP, with greater duration, and frequency of alcohol consumption and dependence [ 39 , 40 , 41 , 44 , 47 , 50 , 52 , 53 , 54 , 61 , 62 , 63 , 64 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 78 , 79 , 81 , 82 , 85 , 86 , 87 ]. Given the cross-sectional nature of this subset of the literature, a causal relationship cannot be established, as exposure and outcome are assessed simultaneously without accounting for temporal sequence.…”

“…Forty-nine cross-sectional studies were included, encompassing 90,889 participants, with study sizes ranging from 18 to 25,710 individuals [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. Participant ages spanned 15 to 100 years, with females accounting for 43.75% across studies.…”

“…One ecological cross-sectional study evaluated insurance reimbursement claims per 1000 population, covering up to 126 million individuals, and was excluded from these averages [ 68 ]. Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 ,…”

“…Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 , 40 , 41 , 46 , 4...…”

“…PN (29) [ 39 , 40 , 41 , 46 , 47 , 48 , 49 , 52 , 53 , 54 , 57 , 59 , 61 , 62 , 64 , 66 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 83 , 85 ] accounted for over half of the diagnoses across all studies, followed by PoN (8) [ 44 , 50 , 56 , 63 , 79 , 81 , 84 , 86 ], painful neuropathy (6) [ 42 , 51 , 60 , 65 , 68 , 82 ], and general neuropathy (6) [ 43 , 45 , 55 , 58 , 69 , 87 ] to a lesser extent. Alcohol dependence (22) [ 40 , 41 , 44 ,…”

A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Alcohol Consumption and Avoidance

“…The pooled estimates for both the effect of alcohol consumption and dependence on the prevalence of neuropathy/NP indicate a protective effect, whereby alcohol use is associated with 50%, and 40% lower prevalence of neuropathy compared to non-use, respectively [ 39 , 42 , 43 , 46 , 48 , 51 , 57 , 58 , 59 , 67 , 70 , 73 , 80 , 84 , 85 ]. This directly contradicts the majority of studies (28/47, 60%) reporting greater prevalence of PN, diabetic PN, chemotherapy-induced PN, PoN, and NP, with greater duration, and frequency of alcohol consumption and dependence [ 39 , 40 , 41 , 44 , 47 , 50 , 52 , 53 , 54 , 61 , 62 , 63 , 64 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 78 , 79 , 81 , 82 , 85 , 86 , 87 ]. Given the cross-sectional nature of this subset of the literature, a causal relationship cannot be established, as exposure and outcome are assessed simultaneously without accounting for temporal sequence.…”

“…Forty-nine cross-sectional studies were included, encompassing 90,889 participants, with study sizes ranging from 18 to 25,710 individuals [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. Participant ages spanned 15 to 100 years, with females accounting for 43.75% across studies.…”

“…One ecological cross-sectional study evaluated insurance reimbursement claims per 1000 population, covering up to 126 million individuals, and was excluded from these averages [ 68 ]. Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 ,…”

“…Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 , 40 , 41 , 46 , 4...…”

“…PN (29) [ 39 , 40 , 41 , 46 , 47 , 48 , 49 , 52 , 53 , 54 , 57 , 59 , 61 , 62 , 64 , 66 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 83 , 85 ] accounted for over half of the diagnoses across all studies, followed by PoN (8) [ 44 , 50 , 56 , 63 , 79 , 81 , 84 , 86 ], painful neuropathy (6) [ 42 , 51 , 60 , 65 , 68 , 82 ], and general neuropathy (6) [ 43 , 45 , 55 , 58 , 69 , 87 ] to a lesser extent. Alcohol dependence (22) [ 40 , 41 , 44 ,…”

A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Alcohol Consumption and Avoidance

“…The pooled estimates for both the effect of alcohol consumption and dependence on the prevalence of neuropathy/NP indicate a protective effect, whereby alcohol use is associated with 50%, and 40% lower prevalence of neuropathy compared to non-use, respectively [ 39 , 42 , 43 , 46 , 48 , 51 , 57 , 58 , 59 , 67 , 70 , 73 , 80 , 84 , 85 ]. This directly contradicts the majority of studies (28/47, 60%) reporting greater prevalence of PN, diabetic PN, chemotherapy-induced PN, PoN, and NP, with greater duration, and frequency of alcohol consumption and dependence [ 39 , 40 , 41 , 44 , 47 , 50 , 52 , 53 , 54 , 61 , 62 , 63 , 64 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 78 , 79 , 81 , 82 , 85 , 86 , 87 ]. Given the cross-sectional nature of this subset of the literature, a causal relationship cannot be established, as exposure and outcome are assessed simultaneously without accounting for temporal sequence.…”

“…Forty-nine cross-sectional studies were included, encompassing 90,889 participants, with study sizes ranging from 18 to 25,710 individuals [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. Participant ages spanned 15 to 100 years, with females accounting for 43.75% across studies.…”

“…One ecological cross-sectional study evaluated insurance reimbursement claims per 1000 population, covering up to 126 million individuals, and was excluded from these averages [ 68 ]. Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 ,…”

“…Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 , 40 , 41 , 46 , 4...…”

“…PN (29) [ 39 , 40 , 41 , 46 , 47 , 48 , 49 , 52 , 53 , 54 , 57 , 59 , 61 , 62 , 64 , 66 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 83 , 85 ] accounted for over half of the diagnoses across all studies, followed by PoN (8) [ 44 , 50 , 56 , 63 , 79 , 81 , 84 , 86 ], painful neuropathy (6) [ 42 , 51 , 60 , 65 , 68 , 82 ], and general neuropathy (6) [ 43 , 45 , 55 , 58 , 69 , 87 ] to a lesser extent. Alcohol dependence (22) [ 40 , 41 , 44 ,…”

A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Alcohol Consumption and Avoidance

“…The pooled estimates for both the effect of alcohol consumption and dependence on the prevalence of neuropathy/NP indicate a protective effect, whereby alcohol use is associated with 50%, and 40% lower prevalence of neuropathy compared to non-use, respectively [ 39 , 42 , 43 , 46 , 48 , 51 , 57 , 58 , 59 , 67 , 70 , 73 , 80 , 84 , 85 ]. This directly contradicts the majority of studies (28/47, 60%) reporting greater prevalence of PN, diabetic PN, chemotherapy-induced PN, PoN, and NP, with greater duration, and frequency of alcohol consumption and dependence [ 39 , 40 , 41 , 44 , 47 , 50 , 52 , 53 , 54 , 61 , 62 , 63 , 64 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 78 , 79 , 81 , 82 , 85 , 86 , 87 ]. Given the cross-sectional nature of this subset of the literature, a causal relationship cannot be established, as exposure and outcome are assessed simultaneously without accounting for temporal sequence.…”

“…Forty-nine cross-sectional studies were included, encompassing 90,889 participants, with study sizes ranging from 18 to 25,710 individuals [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. Participant ages spanned 15 to 100 years, with females accounting for 43.75% across studies.…”

“…One ecological cross-sectional study evaluated insurance reimbursement claims per 1000 population, covering up to 126 million individuals, and was excluded from these averages [ 68 ]. Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 ,…”

“…Publications spanned 1965 to 2024 and included both high- (43/49) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and low-income (6/49) [ 47 , 49 , 58 , 73 , 74 , 75 ] countries. PN (29) [ 39 , 40 , 41 , 46 , 4...…”

“…PN (29) [ 39 , 40 , 41 , 46 , 47 , 48 , 49 , 52 , 53 , 54 , 57 , 59 , 61 , 62 , 64 , 66 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 83 , 85 ] accounted for over half of the diagnoses across all studies, followed by PoN (8) [ 44 , 50 , 56 , 63 , 79 , 81 , 84 , 86 ], painful neuropathy (6) [ 42 , 51 , 60 , 65 , 68 , 82 ], and general neuropathy (6) [ 43 , 45 , 55 , 58 , 69 , 87 ] to a lesser extent. Alcohol dependence (22) [ 40 , 41 , 44 ,…”