Alcohol-induced autonomic dysfunction: a systematic review

Julian, Thomas; Syeed, Rubiya; Glascow, Nicholas; Zis, Panagiotis

doi:10.1007/s10286-019-00618-8

Cited by 25 publications

(21 citation statements)

References 51 publications

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“…Higher RSA values are associated with a greater dynamic range in parasympathetic function and have been found to be physiologically advantageous [ 23 , 79 ]. This wide foundation of research demonstrates the relationship between RSA and pathology, and a growing body of literature has begun connecting alcohol use with autonomic nervous system disruptions [ 13 , 14 , 15 , 21 , 68 , 80 ]. The current study drew novel connections between HRV and functional brain networks in everyday alcohol consumers, observing a significant relationship between shifts in brain network topology and HRV.…”

Section: Discussionmentioning

confidence: 99%

Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers

et al. 2021

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Alcohol consumption is now common practice worldwide, and functional brain networks are beginning to reveal the complex interactions observed with alcohol consumption and abstinence. The autonomic nervous system (ANS) has a well-documented relationship with alcohol use, and a growing body of research is finding links between the ANS and functional brain networks. This study recruited everyday drinkers in an effort to uncover the relationship between alcohol abstinence, ANS function, and whole brain functional brain networks. Participants (n = 29), 24–60 years-of-age, consumed moderate levels of alcohol regularly (males 2.4 (±0.26) drinks/day, females 2.3 (±0.96) drinks/day). ANS function, specifically cardiac vagal tone, was assessed using the Porges-Bohrer method for calculating respiratory sinus arrhythmia (PBRSA). Functional brain networks were generated from resting-state MRI scans obtained following 3-day periods of typical consumption and abstinence. A multi-task mixed-effects regression model determined the influences of HRV and drinking state on functional network connectivity. Results showed differences in the relationship between the strength of network connections and clustering coefficients across drinking states, moderated by PBRSA. Increases in connection strength between highly clustered nodes during abstinence as PBRSA increases demonstrates a greater possible range of topological configurations at high PBRSA values. This novel finding begins to shed light on the complex interactions between typical alcohol abstinence and physiological responses of the central and autonomic nervous system.

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Section: Discussionmentioning

confidence: 99%

Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers

et al. 2021

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“… 34 These characteristics correspond more or less to the background population in which approximately half of the population are smoking, around one-third are severely overweight and 34% drink five or more units at least once a month. 14 CAN may be prevalent in those who consume large quantities of alcohol over a prolonged period of time, 49 and both smoking and obesity have been identified as risk factors of CAN in diabetes. 7 8 However, it is unclear if the same is applicable on individuals without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Normative data on cardiovascular autonomic function in Greenlandic Inuit

Christensen

Hansen

Fleischer

et al. 2021

BMJ Open Diab Res Care

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IntroductionDiabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit.Research design and methodsIn this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex.ResultsBased on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found.ConclusionsThe general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function.

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“…An indirect way in which TBI can lead to autonomic dysfunction is through an interaction with an underlying vulnerability, for example, a tendency towards hypermobility. Another important indirect mechanism by which TBI can result in autonomic dysfunction is by increasing the risk of conditions which are independent risk factors for autonomic dysfunction, for example neurodegenerative disease 25 and alcohol abuse 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Autonomic dysfunction after moderate-severe traumatic brain injury: symptom spectrum and clinical testing outcomes

Vichayanrat

Giovane

et al. 2021

Preprint

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Background and Objective: Survivors of moderate-severe traumatic brain injury (msTBI) frequently experience chronic, debilitating somatic symptoms, which are largely unexplained. The phenomenon of paroxysmal sympathetic hyperactivity, reflecting hyperacute autonomic dysfunction, is well-documented after msTBI. Limited animal and human studies, using experimental measures, have found evidence for autonomic dysfunction after msTBI. However, no studies have investigated the range and type of autonomic symptoms and autonomic dysfunction existing in msTBI. We set out to investigate the presence and type of subjective and objective autonomic dysfunction in msTBI. Methods: We conducted two cohort studies. Cohort 1 comprises msTBI patients prospectively recruited from a regional TBI outpatient clinic, in whom we assessed burden of autonomic symptoms using the Composite Autonomic Symptom Score (COMPASS31) autonomic symptom questionnaire. Cohort 2 comprises msTBI patients who had standard clinical autonomic function testing (supine/tilted catecholamine levels, head-up tilt, Valsalva manoeuvre, respiratory sinus arrhythmia assessment), retrospectively identified from the database of a regional clinical autonomic unit. Results: Cohort 1 comprises 29 msTBI patients (6 females, median age 40 years, range 19-76), with a median time since injury of 19 months (range 4-105). There was multi-domain symptom burden, with all but 3 patients reporting symptoms on the COMPASS31 questionnaire, and 17/29 reporting symptoms in 3+ domains. The most commonly reported symptoms were gastrointestinal (22/29), followed by orthostatic (17/19), pupillomotor (14/29), secretomotor (14/29), bladder (12/29) and, least commonly, vasomotor (6/29). Cohort 2 comprises 19 msTBI patients (7 females, median age 44 years, range 21-64), with a median time between injury and testing of 65 months (range: 2-416). The majority of patients (16/19) had orthostatic symptoms as part of the reason for referral. Clinical autonomic function testing revealed a broad spectrum of autonomic dysfunction: 4/19 had evidence of sympathetic dysfunction, 10/19 had evidence of parasympathetic dysfunction, of which 6 had evidence of mixed dysfunction. Discussion: Our results provide evidence for clinically relevant autonomic dysfunction after moderate-severe TBI, even at the chronic stage. Our study advocates for routine enquiry about potential autonomic symptoms in this population, and the utility of formal clinical autonomic testing in providing diagnoses.

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Alcohol-induced autonomic dysfunction: a systematic review

Cited by 25 publications

References 51 publications

Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers

Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers

Normative data on cardiovascular autonomic function in Greenlandic Inuit

Autonomic dysfunction after moderate-severe traumatic brain injury: symptom spectrum and clinical testing outcomes

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