Is There a Relation between Risk Groups or Initial CD4 T Cell Counts and Prevalence of Seborrheic Dermatitis in HIV-Infected Patients?

Schaub, Nora; Drewe, Jürgen; Sponagel, L; Gilli, L.; Courvoisier, S.; Gyr, Niklaus; Rufli, T; Battegay, Manuel; Itin, Peter

doi:10.1159/000018087

Cited by 20 publications

(21 citation statements)

References 7 publications

(9 reference statements)

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“…109,110 Furthermore, there have been reports of aggravation during immune reconstitution inflammatory syndrome and reports that antiretroviral treatment does not alter the prevalence or the course of SD. 111,112 With respect to histopathology, the findings of SD in HIV-positive patients are similar to those found in HIV-negative patients; however, there appears to be greater follicular involvement in the lesions and more plasmocytes in the inflammatory infiltrate in the HIVpositive patients. 17,78,101 The clinical appearance of SD is typical, affecting areas rich in sebaceous glands and accompanied or not by pruritus.…”

Section: Seborrheic Dermatitis and Hivmentioning

confidence: 54%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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Section: Seborrheic Dermatitis and Hivmentioning

confidence: 54%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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“…The relative prevalence of 16.3% in mountain guides is inferior to the 20–83% in HIV-infected persons [2, 3, 4]and to the 44% in alcohol-addicted mouth and throat cancer patients. Patients with other types of cancer or with alcohol abuse only had prevalences of 4 and 2%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies revealed a significant association between disease progression, immunologic status and manifestation and severity of SD [3, 4, 15]. However, a recent study showed that it was not the initial CD4 T cell count but the risk group of HIV-positive individuals that influences the prevalence and time course of SD [2]. …”

Section: Resultsmentioning

confidence: 99%

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High Prevalence of Seborrhoeic Dermatitis on the Face and Scalp in Mountain Guides

Moehrle

Dennenmoser²,

Schlagenhauff³

et al. 2000

Dermatology

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Background: High incidence rates of seborrhoeic dermatitis (SD) have been reported in HIV-infected individuals, indicating immunosuppression to be involved in the pathogenesis. Objective: To establish the prevalence of SD in mountain guides who have a high occupational exposure to solar UV radiation. Patients and Methods: In November 1999, 283 mountain guides were physically examined on the face and scalp for symptoms of SD in Austria (n = 75), Switzerland (n = 123) and Germany (n = 85); they were 21.3–93.1 years of age (median age 41.4 years). Results: Forty-six of 283 (16.3%) mountain guides when examined clinically were found to have SD. The median age of mountain guides with SD was 41.2 years. There were similar incidence rates in all three countries. Conclusion: SD affects mountain guides in a clearly higher percentage as the general population. We suggest UV-induced immunosuppression due to occupational sun exposure as a pathogenetic factor.

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“…As HIV-positive patients very often show seborrheic dermatitis, we investigated whether there was a difference in incidence according to risk groups and disease state [31], in particular between homo- or bisexual HIV-infected patients and HIV-infected intravenous drug users. We compared the initial CD4 T-cell count at the first positive HIV test in patients with and without seborrheic dermatitis.…”

Section: Introductionmentioning

confidence: 99%

HIV Dermatology in Switzerland – From the Beginning to the Present

Itin¹,

Fistarol²

2005

Dermatology

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The panendemic of HIV has markedly influenced the dermatology of our generation. This new infection produced atypical manifestations of known dermatological diseases. And beyond that, mucocutaneous diseases emerged, which had not yet been described. Classical epidemiological studies concluded that clustering of AIDS cases could be explained only if AIDS was an infection transmitted by sexual activity or blood. Switzerland was hit early on by the HIV epidemic, and Theo Rufli, the leading expert on sexually transmitted diseases in our country, was involved from the beginning. He contributed with his team to a better delineation of the cutaneous manifestations of HIV infection by directing one of the largest prospective studies on the natural course of cutaneous manifestations of HIV. In addition, he participated in studies which documented new skin diseases in HIV-infected patients. From the very beginning of the epidemic in Switzerland, Theo Rufli founded an organization which helped patients cope with their diagnosis. In Basel, an anonymous consultation facility was established. Theo Rufli also strongly supported the ‘Stop AIDS’ campaign. This review looks back on the history of HIV in Switzerland and especially in Basel.

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Is There a Relation between Risk Groups or Initial CD4 T Cell Counts and Prevalence of Seborrheic Dermatitis in HIV-Infected Patients?

Cited by 20 publications

References 7 publications

Dermatite seborreica

Dermatite seborreica

High Prevalence of Seborrhoeic Dermatitis on the Face and Scalp in Mountain Guides

HIV Dermatology in Switzerland – From the Beginning to the Present

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