Is there a local production of nitrosamines by the vaginal microflora in anaerobic vaginosis/trichomoniasis?

Pavic, N.

doi:10.1016/0306-9877(84)90159-2

Cited by 52 publications

(29 citation statements)

References 10 publications

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“…It is hypothesized that bacterial vaginosis could be important in the development of neoplasia of the cervix, because the abnormal microflora in this condition produce carcinogenic nitrosamins. 21 In this study, only one of the patients had high-grade cervical intraepithelial neoplasia and both of her test results were positive for bacterial vaginosis. The hypothesis above should be tested among the women in whom cervical neoplasia is more prevalant.…”

Section: Discussionmentioning

confidence: 60%

Bacterial vaginosis: comparison of Pap smear and microbiological test results

et al. 2004

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Section: Discussionmentioning

confidence: 60%

Bacterial vaginosis: comparison of Pap smear and microbiological test results

et al. 2004

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“…The clinico-pathologic condition characterized by redness in the vaginal wall, bad-odored discharge and the presence of clue cells in cervicovaginal specimens, which results from the transformation of the acidic vaginal pH to an alkaline pH via metabolic activity of the aforedefined bacteria is known as BV 6 . It is also reported that BV causes premature rupture of membranes, preterm delivery and endometritis and, according to some authors, BV has possible carcinogenic effects due to abnormal vaginal cytology and mosaic colposcopic pattern in the cervix [13][14][15][16][17] . Various methods have been recommended for the evaluation of preparations for BV by Gram stain.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Gram Stain and Pap Smear Procedures in theDiagnosis of Bacterial Vaginosis

Vardar

Maral²,

İnal³

et al. 2002

Infectious Diseases in Obstetrics and Gynecology

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Objective: The purpose of this study was to examine the characteristics of Gram stain versus Pap smear in diagnosis of bacterial vaginosis (BV). Methods: One-thousand and sixty women were enrolled in this study. All cases with symptoms of BV were determined by Amsel's criteria, which were accepted as the gold standard for diagnosis of BV. Pap smear and Gram stain evaluations were compared according to Amsel's criteria, without viewing the clinical results of the patients. Gram stain and Pap smear results were determined as negative or positive according to Amsel's criteria. Sensitivity, specifity and positive predictive values were calculated. Results: After accepting the cases that were diagnosed as BV according to Amsel's criteria as reference cases, the sensitivity of the Gram stain method was calculated as 97% and the sensitivity of the Pap smear method as 93%. Similar specificity rates were obtained with both methods in diagnosis of BV related to the clinical results. There were no statistically significant differences in diagnosis of BV between these two groups. Conclusion: If Amsel's criteria are accepted as the gold standard for diagnosis of BV, Gram stain and Pap smear methods will give similar results in diagnosis.

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“…As a whole, the infectious findings on the Pap smeaers were constituting approximately 9.8% of the participants. Because of the production of microfloral carcinogenic nitrosamines, bacterial vaginosis has been insinuated in the progression of cervical displasia, as well as HPV (Pavic, 1984;Gillet et al, 2012;Jahic et al, 2013).…”

Section: Discussionmentioning

confidence: 99%