Is There a Link Between Obesity and Asthma?

Kim, Sang-Ha; Sutherland, E. Rand; Gelfand, Erwin W.

doi:10.4168/aair.2014.6.3.189

Cited by 87 publications

(74 citation statements)

References 72 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two cluster analyses of large samples of adults with asthma have observed a distinct subphenotype of adults with asthma; individuals with this phenotype are more likely to be female and obese and to have asthma that is of later onset and less atopic than in other subgroups (34,35). The occurrence of adult-onset asthma (or symptoms diagnosed as asthma) in this subgroup could be due to inflammation related to obesity and adipokine dysregulation rather than allergy or other mechanisms (36), to impaired pulmonary function (36) or dyspnea (37) related to mechanical effects of obesity rather than inflammatory airways disease, and/or to gastroesophageal reflux (38). These factors may overshadow the effects of tobacco smoking in the subset of women who are obese and have adult-onset asthma or asthma-like symptoms due to mechanisms other than epithelial injury related to environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Coogan¹,

Castro‐Webb²,

Yu³

et al. 2015

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Evidence linking active or passive smoking to the incidence of adult-onset asthma is inconsistent with both positive and inverse associations being reported. Most previous studies of active smoking have not accounted for passive smoke exposure, which may have introduced bias.Objectives: To assess the separate associations of active and passive smoking to the incidence of adult-onset asthma in the U.S. Black Women's Health Study, a prospective cohort of African American women followed since 1995 with mailed biennial questionnaires.Methods: Active smoking status was reported at baseline and updated on all follow-up questionnaires. Passive smoke exposure during childhood, adolescence, and adulthood was ascertained in 1997. Asthma cases comprised women who reported doctordiagnosed asthma with concurrent asthma medication use. Cox regression models were used to derive multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for former and current smoking and for passive smoking among nonsmokers compared with a reference category of never active or passive smokers.Measurements and Main Results: Among 46,182 participants followed from 1995 to 2011, 1,523 reported incident asthma. The multivariable HRs for former active smoking, current active smoking, and passive smoking only were, respectively, 1.36 (95% CI, 1.11-1.67), 1.43 (95% CI, 1.15-1.77), and 1.21 (95% CI, 1.00-1.45), compared with never active/passive smoking. Conclusions:In this large population with 16 years of follow-up, active smoking increased the incidence of adult-onset asthma, and passive smoke exposure increased the risk among nonsmokers. Continued efforts to reduce exposure to tobacco smoke may have a beneficial effect on the incidence of adult-onset asthma.

show abstract

Section: Discussionmentioning

confidence: 99%

Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Coogan¹,

Castro‐Webb²,

Yu³

et al. 2015

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…The chronic, low-grade, systemic inflammation that characterizes obesity promotes other obesity-related conditions (18,23,42,54) and may also play a role in the etiology of obesity-related asthma (26,49,53). Circulating TNF-␣ is increased both in obese humans and obese mice (22,36,45,58) and may be of relevance for asthma, since exogenous administration of TNF-␣ has the capacity to induce AHR (55).…”

mentioning

confidence: 99%

Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-α

Williams¹,

Mathews²,

Kasahara³

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

“…Los motivos principales que han llevado a relacionar la mayor prevalencia de asma en sujetos obesos pueden ser la disminución de la capacidad funcional pulmonar y el aumento del reflujo gastroesofágico presente con frecuencia en estos pacientes, el estado proinflamatorio descrito en obesidad, así como la existencia de cromosomas que están relacionados con la obesidad y con el asma (7,8).…”

Section: Obesidadunclassified

Inﬂuencia del estado nutricional sobre el padecimiento de asma en la población

Rodríguez-Rodríguez

González-Rodríguez

et al. 2016

Nutr Hosp

View full text Add to dashboard Cite

Rodríguez-Rodríguez E, Rodríguez-Rodríguez P, González-Rodríguez LG, López-Sobaler AM. Infl uencia del estado nutricional sobre el padecimiento de asma en la población. Nutr Hosp 2016;33(Supl. 4):63-67 DOI:http://dx.dpi.org/10.20960/nh.349Infl uencia del estado nutricional sobre el padecimiento de asma en la población AbstractAsthma is a chronic disease characterized by airway infl ammation and bronchoconstriction. There are different factors that can favor this process, but the role of diet is especially important. Thus, inadequate nutritional status in some nutrients causes alterations in immune function and antioxidant defense mechanisms that may facilitate the onset of infl ammatory processes in the pulmonary system. Thus, intervention studies with antioxidant vitamins have shown mixed results. Nevertheless, having in mind the low consumption of fruits and vegetables and the low intake of antioxidant nutrients of the population, a fi rst step could be to approximate the diet to the theoretical ideal to reach the recommended intakes. Furthermore, it is important follow an adequate diet during the pregnancy because during this period the diet affects fetal development, which can be related to the suffering of asthma in childhood, and even in adulthood. In addition, in relation with other less studied nutrients, such as vitamin D and those nutrients methyl donors, would be interesting to conduct randomized controlled trials in people with risk of asthma or with established asthma to test their effect. ResumenEl asma es una enfermedad crónica caracterizada por una obstrucción reversible de las vías aéreas debido a una infl amación de las mismas. Existen diferentes factores que pueden favorecer este proceso, pero el papel de la dieta es especialmente importante. De esta manera, una dieta incorrecta y la situación inadecuada en algunos nutrientes produce alteraciones de la función inmunitaria y de los mecanismos de defensa antioxidante que pueden facilitar la aparición de procesos infl amatorios en el árbol bronquial. En este sentido, con relación a los estudios de intervención con vitaminas antioxidantes, aunque en general han dado resultados variados, si se tiene en cuenta el bajo consumo de frutas y verduras de la población, así como la baja ingesta de nutrientes antioxidantes encontrados en un elevado porcentaje de la misma, un primer paso podría ser aproximar la dieta al ideal aconsejado y cubrir las ingestas recomendadas de dichos nutrientes. Hay que resaltar la importancia de cuidar la dieta durante el embarazo, ya que durante este periodo la dieta infl uye sobre el desarrollo fetal, que puede ser clave para sufrir asma o no en la edad infantil e incluso en la edad adulta. Además, con relación a otros nutrientes menos estudiados, como la vitamina D y aquellos nutrientes donadores de grupos metilo, sería interesante llevar a cabo ensayos clínicos controlados y aleatorizados en población con riesgo de presentar asma, o con asma ya establecido, para comprobar su efecto.

show abstract

Is There a Link Between Obesity and Asthma?

Cited by 87 publications

References 72 publications

Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-α

Inﬂuencia del estado nutricional sobre el padecimiento de asma en la población

Contact Info

Product

Resources

About