Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Coogan, Patricia F.; Castro‐Webb, Nelsy; Yu, Jeffrey; O’Connor, George T.; Palmer, Julie R.; Rosenberg, Lynn

doi:10.1164/rccm.201406-1108oc

Cited by 88 publications

(81 citation statements)

References 40 publications

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“…This susceptibility might be explained by the fact that any air pollution effect may be masked among smokers, who may already have a higher risk of asthma [45].…”

Section: Smokingmentioning

confidence: 99%

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Burte

Nadif

Jacquemin

2016

Curr Envir Health Rpt

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In this review, we identified 15 studies in children and 10 studies in adults that assessed the association between long-term exposure to air pollution and incident asthma and that conducted stratified analyses to explore potential susceptibility factors. Overall, adult never/former smokers seem to be at higher risk of incident asthma due to air pollution. Children without atopy and children from low socio-economic status families also seem to be at higher risk of incident asthma due to air pollution. While interaction between air pollution and genes involved in the response to oxidative stress pathways have been explored, results are somewhat inconsistent and in need of replication. To evaluate interactions, large sample sizes are necessary and much more research, including data pooling 2 from existing studies, is needed to further explore susceptible factors for asthma incidence due to long-term air pollution exposure.

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“…This susceptibility might be explained by the fact that any air pollution effect may be masked among smokers, who may already have a higher risk of asthma [45].…”

Section: Smokingmentioning

confidence: 99%

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Burte

Nadif

Jacquemin

2016

Curr Envir Health Rpt

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“…Most longitudinal studies have found an increased risk of new-onset asthma among current smokers with respect to never-smokers [1,2,3,4,5,6,7], the relative risk ranging between 1.4 and 3. However, a few studies report no effect of current smoking on asthma onset [8,9,10,11], or even a protective effect [12].…”

Section: Introductionmentioning

confidence: 99%

“…The current literature [7,10,16] reports several reasons that could bias the estimates of the smoking-asthma association and lead to discrepant reports:…”

Section: Introductionmentioning

confidence: 99%

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Smoking and New-Onset Asthma in a Prospective Study on Italian Adults

Verlato

Nguyen

Marchetti³

et al. 2016

Int Arch Allergy Immunol

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Background: The existence of a cause-effect relation between active smoking and new-onset asthma in adults, although supported by several studies, has not been proven yet. Aims: We aimed to prospectively study asthma incidence as a function of smoking habits in the Italian adult population. Methods: A population-based cohort of 5,241 non-asthmatics was enrolled in Verona and Sassari in 1998-2000. The cohort was contacted again in 2007-2009 within the Gene-Environment Interactions in Respiratory Diseases study, and 3,187 subjects (60.8%) answered a screening questionnaire on smoking habits and respiratory disorders. The relation between smoking habits and self-reported new-onset asthma, defined as asthma attacks/use of medicines for asthma, was investigated by a multivariable logistic model. Results: During follow-up, 145 new cases of asthma were observed, yielding a cumulative incidence of 4.6% (95% CI 3.9-5.4); cumulative incidence of asthma did not significantly differ among never-smokers (76/1,666 = 4.6%), ex-smokers (30/554 = 5.4%) and current smokers (39/883 = 4.4%) (p = 0.641). In a multivariable analysis, the most important risk factor for asthma onset was allergic rhinitis (OR = 4.00, 95% CI 3.68-4.35). Compared to never-smokers, the risk of asthma onset was slightly increased in ex-smokers (OR = 1.28, 1.09-1.49) but not in current smokers (OR 1.01, 0.66-1.53). Current smoking became a significant predictor only when both new-onset wheezing and new-onset asthma were considered as the outcome (OR = 2.03, 1.35-3.05). Conclusions: In this prospective study, current smoking was not a risk factor for new-onset asthma, unless new-onset wheezing was also considered. The increase in asthma incidence among ex-smokers was likely due to reverse causation.

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“…The underlying pathophysiological mechanisms include a combination of changes in the pulmonary immune system, pro-inflammatory response, and increased oxidative stress (128, 129). …”

Section: Introductionmentioning

confidence: 99%

The Danish National Database for Asthma: establishing clinical quality indicators

Hansen

Hoffmann-Petersen

Sverrild

et al. 2016

European Clinical Respiratory Journal

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Asthma is one of the most common chronic diseases worldwide affecting more than 300 million people. Symptoms are often non-specific and include coughing, wheezing, chest tightness, and shortness of breath. Asthma may be highly variable within the same individual over time. Although asthma results in death only in extreme cases, the disease is associated with significant morbidity, reduced quality of life, increased absenteeism, and large costs for society. Asthma can be diagnosed based on report of characteristic symptoms and/or the use of several different diagnostic tests. However, there is currently no gold standard for making a diagnosis, and some degree of misclassification and inter-observer variation can be expected. This may lead to local and regional differences in the treatment, monitoring, and follow-up of the patients. The Danish National Database for Asthma (DNDA) is slated to be established with the overall aim of collecting data on all patients treated for asthma in Denmark and systematically monitoring the treatment quality and disease management in both primary and secondary care facilities across the country. The DNDA links information from population-based disease registers in Denmark, including the National Patient Register, the National Prescription Registry, and the National Health Insurance Services register, and potentially includes all asthma patients in Denmark. The following quality indicators have been selected to monitor trends: first, conduction of annual asthma control visits, appropriate pharmacological treatment, measurement of lung function, and asthma challenge testing; second, tools used for diagnosis in new cases; and third, annual assessment of smoking status, height, and weight measurements, and the proportion of patients with acute hospital treatment. The DNDA will be launched in 2016 and will initially include patients treated in secondary care facilities in Denmark. In the nearby future, the database aims to include asthma diagnosis codes and clinical data registered by general practitioners and specialised practitioners as well.

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Active and Passive Smoking and the Incidence of Asthma in the Black Women’s Health Study

Cited by 88 publications

References 40 publications

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Smoking and New-Onset Asthma in a Prospective Study on Italian Adults

The Danish National Database for Asthma: establishing clinical quality indicators

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