Is There a Genetic Predisposition to Frozen Shoulder?

Prodromidis, Apostolos D.; Charalambous, Charalambos Panayiotou

doi:10.2106/jbjs.rvw.o.00007

Cited by 50 publications

(42 citation statements)

References 45 publications

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“…In particular, familiarity was investigated by collecting twin and familial clustering studies. 31 In the same study, the authors also performed a meta-analysis of immunological researches, which investigated the role of human leukocyte antigen (HLA)-B27, a protein involved in triggering the inflammatory response, as a risk factor for SS. Although unbiased genetic approaches were lacking and insufficient to definitively confirm this hypothesis, a significantly higher rate of HLA-B27 positivity in patients with idiopathic SS as compared with controls was reported, suggesting a genetic link with this condition.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Shoulder Stiffness: Current Concepts

Cucchi

Marmotti

Giorgi

et al. 2017

Joints

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Shoulder stiffness is a condition of painful restriction of the glenohumeral range of motion. Numerous risk factors for primary and postoperative shoulder stiffness have been described. This article summarizes the known aspects of the pathophysiology of shoulder stiffness, with special attention to elements of molecular biology and genetics, which could influence the risk of developing shoulder stiffness. Furthermore, the role of hormonal and metabolic factors, medical disorders, drugs, and of other published risk factors for primary and postoperative shoulder stiffness is reviewed and discussed. Finally, aspects related to shoulder surgery and postoperative rehabilitation protocols, which could influence the development of postoperative stiffness are presented.

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Section: Introductionmentioning

confidence: 99%

“…Although unbiased genetic approaches were lacking and insufficient to definitively confirm this hypothesis, a significantly higher rate of HLA-B27 positivity in patients with idiopathic SS as compared with controls was reported, suggesting a genetic link with this condition. 31 …”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Shoulder Stiffness: Current Concepts

Cucchi

Marmotti

Giorgi

et al. 2017

Joints

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“…In the same review, the authors also investigated HLA-B27 and the risk of adhesive capsulitis through a meta-analysis. They found a significantly higher rate of HLA-B27 positivity among patients with idiopathic adhesive capsulitis than in controls [20]. HLA-B27 is a protein involved in inflammatory responses, and patients with ax-SpA have a high HLA-B27-positive rate.…”

Section: Discussionmentioning

confidence: 97%

“…Regarding familial clustering, previous studies found a positive family history in first-degree relatives associated with adhesive capsulitis [19]. Authors of a recent systematic review investigated the association of adhesive capsulitis with family history and race by collecting twin and familial clustering studies; they found a genetic association in adhesive capsulitis [20]. In the same review, the authors also investigated HLA-B27 and the risk of adhesive capsulitis through a meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Patients with Axial Spondyloarthritis Are at Risk of Developing Adhesive Capsulitis: Real-World Evidence Database Study in Taiwan

Huang

Wang

Lin

et al. 2020

JCM

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Patients with axial spondyloarthritis (ax-SpA) present with inflammation invading the axial skeleton. Symptoms of ax-SpA interfere with patients' quality of life, and peripheral symptoms are also noted. Human leukocyte antigen B27 was associated with adhesive capsulitis. However, epidemiological studies investigating the associated incidence and risk factors for patients with ax-SpA with adhesive capsulitis are limited. The data of patients with ax-SpA were recorded during the 2004-2008 period and followed to the end of 2010. The control cohort comprised age-and sex-matched non-ax-SpA subjects. A Cox multivariate proportional hazards model was applied to analyze the risk factors for adhesive capsulitis. The hazard ratio (HR) and adjusted hazard ratio (aHR) were estimated between the study and control cohorts after confounders were adjusted for. Effects of sulfasalazine (SSZ), methotrexate (MTX), and hydroxychloroquine (HCQ) use on adhesive capsulitis risk were also analyzed. We enrolled 2859 patients with ax-SpA in the study cohort and 11,436 control subjects. A higher incidence of adhesive capsulitis was revealed in the ax-SpA cohort: The crude HR was 1.63 (95% CI, 1.24-2.13; p < 0.001), and the aHR was 1.54 (95% CI, 1.16-2.05; p = 0.002). For patients with ax-SpA using SSZ or HCQ, no difference in aHR was noted compared with control participants, but patients with ax-SpA treated with MTX had higher HR and aHR than controls. Patients with ax-SpA are at risk for adhesive capsulitis. When these patients receive SSZ or HCQ, the risk of adhesive capsulitis can be lowered compared with that of the control cohort.

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“…it usually appears in females aged 40-60 and affects the dominant hand [66]. other researchers record higher predilection in white patients, patients with a positive family history and with a positive Hla-b27 antigen [68]. the course of the disease may be acute (< 6 weeks), subacute (6-12 weeks) or chronic (> 6 months).…”

Section: C) Palpitation Examinationmentioning

confidence: 99%

Recommendations of the Polish Society of Physiotherapy, Polish Society of Family Medicine and the College of Family Physicians in Poland in the scope of physiotherapy in the painful shoulder syndrome in primary healthcare

Kassolik¹,

Rajkowska-Labon²,

Tomasik³

et al. 2018

fmpcr

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4 college of Family physicians in poland 5 Department of Family medicine, chair of internal Diseases and Gerontology, jagiellonian university medical college in krakow, poland 6 academy of physical Education in katowice, poland 7 university of computer science and skills, lodz, poland 8 polish society of Family medicine, poland 9 Department of Family medicine, wroclaw medical university, poland A -study Design, B -Data collection, C -statistical analysis, D -Data interpretation, E -manuscript preparation, F -literature search, G -Funds collection the objective of these guidelines in the scope of physiotherapy in primary healthcare is to suggest simple, uncomplicated and more cost-effective physiotherapeutic activities in patients experiencing pain due to painful shoulder syndrome. a general practitioner should decide whether the treatment undertaken within primary healthcare, including the process of physiotherapy, is effective and sufficient, or whether it requires more advanced activities, such as advanced diagnostics and further specialist treatment. the authors of the recommendations, apart from massage, also include procedures in the scope of kinesiotherapy, physiotherapy and orthopedic equipment. according to the authors, the aim of recovering the correct spatial system, called structural homeostasis, in the shoulder girdle, is, first of all, normalization of muscle tension and then inclusion in a rehabilitation program covering the methods to recover and consolidate the correct models of motor activity. the starting point for determining a rehabilitation program should be the ability to prepare a simple assessment of the patient's condition. this may result from a palpation examination to determine the incorrect distribution of resting tension in the area of the muscles and tendons engaged in the pathology and causing pain. the authors believe that such a solution contains the key to reducing the costs of treatment, providing access to physical therapists and quick assistance in the scope of improvement of a patient's clinical condition. at the same time, they emphasize the need to correct the previous healthcare model, so that it becomes a more effective tool in maintaining health. SummaryISSN 1734-3402, eISSN 2449-8580 this is an open access article distributed under the terms of the creative commons attribution-noncommercial-sharealike 4.0 international (cc by-nc-sa 4.0). license (http://creativecommons.org/licenses/by-nc-sa/4.0/). kassolik k, Rajkowska-labon E, tomasik t, Gieremek k, Dobrzycka a, andrzejewski w, kiljański m, kurpas D. Recommendations of the polish society of physiotherapy, polish society of Family medicine and college of Family physicians in poland in the scope of physiotherapy in painful shoulder syndrome in primary healthcare. Fam Med Prim Care Rev 2018; 20(3): 277-290, doi: https://doi.org/10.5114/ fmpcr.2018.78274.

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Is There a Genetic Predisposition to Frozen Shoulder?

Abstract: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Cited by 50 publications

References 45 publications

Risk Factors for Shoulder Stiffness: Current Concepts

Risk Factors for Shoulder Stiffness: Current Concepts

Patients with Axial Spondyloarthritis Are at Risk of Developing Adhesive Capsulitis: Real-World Evidence Database Study in Taiwan

Recommendations of the Polish Society of Physiotherapy, Polish Society of Family Medicine and the College of Family Physicians in Poland in the scope of physiotherapy in the painful shoulder syndrome in primary healthcare

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