Is there a differential impact of parity on blood pressure by age?

Dratva, Julia; Schneider, Cornelia; Schindler, Christian; Stolz, Daiana; Gerbase, Margaret W.; Pons, Marco; Bettschart, Robert; Gaspoz, Jean‐Michel; Künzli, Nino; Zemp, Elisabeth; Probst‐Hensch, Nicole

doi:10.1097/hjh.0000000000000325

Cited by 14 publications

(15 citation statements)

References 32 publications

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“…16 A separate prior investigation demonstrated that this inverse association may only be present in younger versus older cohorts of women. 17 We extended prior findings by accounting for several pregnancy complications, including preeclampsia.…”

Section: Discussionmentioning

confidence: 78%

Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure

et al. 2017

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Pregnancy characteristics are associated with risk of cardiovascular diseases, but their independent associations with hypertension or blood pressure levels remain uncertain. We linked the Swedish Medical Birth Register with Västerbotten Intervention Programme data (Northern Sweden). Using linear and logistic regression, we related pregnancy factors in any prior pregnancy with blood pressure and hypertension at age 40 years in 15,896 parous women free of prepregnancy hypertension. Pregnancy factors included parity, age at first delivery, preeclampsia, gestational diabetes, placental abruption, shortest gestational age small for gestational age baby (SGA; < 3rd percentile for birth weight) or stillbirth. We defined hypertension as systolic BP ≥ 140 and/or DBP ≥ 90 mmHg and/or antihypertensive use. Multivariable models were adjusted for all pregnancy factors and potential lifestyle and sociodemographic confounders. At age 40 years, 1,535 women (9.6%) had hypertension. In multivariable models, lower parity, younger age at first birth, preeclampsia, SGA, and placental abruption were independently associated with higher systolic and/or diastolic blood pressure levels at age 40 years. Younger age at first birth, preeclampsia, gestational age <32 versus ≥ 37 weeks and SGA, were independently associated with hypertension. Our findings raise the possibility that earlier and more frequent BP screening may be desirable in women with these pregnancy characteristics.

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Section: Discussionmentioning

confidence: 78%

Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure

et al. 2017

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“…As maternal protection conferred by delivery, an inverse correlation between parity and the prevalence of hypertension has been previously reported. 14 15) According to similar series studies performed on this topic, as parity increased, the blood pressure decreased up to 20 years after delivery. 9) In addition, improved functions of vascular endothelial cells were maintained even after delivery, according to some reports.…”

Section: Discussionmentioning

confidence: 95%

“… 19 20 21) The inconsistency among the previous observations might arise from the study design, number of enrolled patients, and adjustment for confounding variables. 15) In particular, according to many studies, the key risk factors for hypertension in women, such as age, menopause, and BMI, serve as the greatest confounding variables. 15) …”

Section: Discussionmentioning

confidence: 99%

Association between Parity and Blood Pressure in Korean Women: Korean National Health and Nutrition Examination Survey, 2010-2012

et al. 2015

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BackgroundPregnancy considerably alters cardiovascular dynamics, and thereby affects the transition of blood pressure after delivery in women. We aimed to analyze the association between parity and blood pressure in Korean adult women.MethodsWe included 8,890 women who participated in Korean National Health and Nutrition Examination Survey between 2010 and 2012. We divided the population according to the menopause status and analyzed the association between parity and blood pressure by using multiple regression analysis, and on hypertension, by using logistic regression analysis.ResultsSystolic and diastolic blood pressures were significantly associated with parity in premenopausal women (β=-0.091 [P<0.001] and β=-0.069 [P<0.001], respectively). In the analysis that excluded women receiving antihypertensive medication, the systolic and diastolic blood pressure of postmenopausal women were significantly associated with parity (β=-0.059 [P=0.022] and β=-0.054 [P=0.044], respectively). Parity was found to prevent hypertension after adjustment for confounders in postmenopausal women (odds ratio, 0.55; 95% confidence interval, 0.310-0.985).ConclusionWe found that parity prevented hypertension in Korean women.

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“…30 A change in paternity is probably the best known risk factor for PE in multiparous women, with OR of 1.30-1.56 for PE, depending on the diagnostic criteria, and an OR of 1.99 for the combined group of pregnancy-related hypertensive disorders regardless of diagnostic criteria. In general, multiparity reduces the risk of PE, and among nonpregnant women, multiparity has a protective effect on blood pressure in women below 40 years of age, an effect that is related to the number of births.…”

Section: Discussionmentioning

confidence: 99%

“…In general, multiparity reduces the risk of PE, and among nonpregnant women, multiparity has a protective effect on blood pressure in women below 40 years of age, an effect that is related to the number of births. 30 A change in paternity is probably the best known risk factor for PE in multiparous women, with OR of 1.30-1.56 for PE, depending on the diagnostic criteria, and an OR of 1.99 for the combined group of pregnancy-related hypertensive disorders regardless of diagnostic criteria. 31 However, this effect is influenced by the history of PE with the previous partner, being increased among women without, and decreased in women with, PE in the preceding pregnancy.…”

Section: Non-immune Immune Non-immune Immunementioning

confidence: 99%